  Standard route shields | |
 Interstate Highways highlighted in red | |
| Highway names | |
|---|---|
| Interstates | Interstate X (I-X) |
| US Highways | U.S. Route X (US X) |
| State | Mississippi Highway X (MS X) |
| System links | |
In the U.S. state of Mississippi, Interstate Highways are maintained by the Mississippi Department of Transportation (MDOT).
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 I-10 | 77.056 | 124.010 | I-10 at Louisiana state line (East Pearl River) east of Slidell | I-10 at Alabama state line near Missala | — | — | ||
 I-14 | — | — | Louisiana state line | Alabama state line | proposed | — | Proposed across the central part of the state, from the Louisiana state line (Mississippi River) near Natchez to the Alabama state line near Meridian; Proposal for the Fourteenth Amendment Highway | |
 I-20 | 154.5 | 248.6 | I-20 at Louisiana state line (Vicksburg Bridge) near Vicksburg | I-20/I-59 at Alabama state line near Kewanee | — | — | ||
 I-22 | 106.0 | 170.6 | US 78/I-269 in Byhalia | I-22 at Alabama state line east of Tremont | — | — | ||
 I-55 | 290.41 | 467.37 | I-55 at Louisiana state line near Osyka | I-55 at Tennessee state line near Southaven | — | — | ||
 I-59 | 169 | 272 | I-59 at Louisiana state line (East Pearl River) near Nicholson | I-20/I-59 at Alabama state line near Kewanee | — | — | ||
 I-69 | 23.390 | 37.643 | MS 304/MS 713 east of Banks | I-55 north of Hernando | — | — | Present highway co-signed with I-55 from eastern terminus to Tennessee state line. Proposed section to run from western terminus using existing US 61 roadbed to Greenville Bridge near Refuge | |
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 I-110 | 4.10 | 6.60 | US 90 in Biloxi | I-10 in D'Iberville | 1988 | current | ||
 I-220 | 12.01 | 19.33 | I-20 in Jackson | I-55 in Ridgeland | 1981 | current | Beltway around northwestern Jackson | |
 I-269 | 23.79 | 38.29 | I-55/I-69 in Hernando | I-269 at Tennessee state line near Southaven | 2015 | current | Outer beltway of Memphis, northern beltway in Tennessee signed as SR 385 | |
 I-310 | 6 | 9.7 | US 90 in Gulfport | I-10 in Gulfport | proposed | — | Proposed connector to the Port of Gulfport; also has the designation of MS 601 | |
