   Standard route shields | |
| Highway names | |
|---|---|
| Interstates | Interstate X (I-X) |
| US Highways | U.S. Route X (US X) |
| State | Mississippi Highway X (MS X) |
| System links | |
In the U.S. state of Mississippi, U.S. Routes are maintained by the Mississippi Department of Transportation (MDOT).
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 11 | 173.1 | 278.6 | I-59 at Nicholson | US 11 at the Alabama state line near Kewanee | 1926 | current | ||
 US 45 | 273.5 | 440.2 | US 45 at the Alabama state line near State Line | US 45 at the Tennessee state line near Wenesoga | 1926 | current | ||
 US 49 | 204.2 | 328.6 | US 90 at Gulfport | US 49E/US 49W at Yazoo City | 1926 | current | Southern segment | |
| US 49 | 40.9 | 65.8 | US 49E/US 49W at Tutwiler | US 49 at the Arkansas state line (Helena Bridge) near Helena | 1926 | current | Northern segment | |
 US 49E | 85.862 | 138.181 | US 49 & US 49W at Yazoo City | US 49 & US 49W at Tutwiler | 1926 | current | ||
 US 49W | 81.894 | 131.796 | US 49 & US 49E at Yazoo City | US 49 & US 49E at Tutwiler | 1926 | current | ||
 US 51 | 267.2 | 430.0 | US 51 at the Louisiana state line near Osyka | US 51 at the Tennessee state line near Horn Lake | 1926 | current | ||
 US 61 | 299.8 | 482.5 | US 61 at the Louisiana state line near Woodville | US 61 at the Tennessee state line near Lake View | 1926 | current | ||
 US 65 | 2.9 | 4.7 | US 61 in Natchez | US 65 at the Louisiana state line near Natchez | 1926 | 2005 | Entirely replaced by US 425 | |
 US 72 | 89.9 | 144.7 | US 72 at the Tennessee state line near Barton | US 72 at the Alabama state line near Oldham | 1926 | current | ||
 US 78 | 118.0 | 189.9 | US 78 at the Tennessee state line near Olive Branch | US 78 at the Alabama state line near Tremont | 1926 | current | ||
 US 80 | 157 | 253 | US 80 at the Louisiana state line (Vicksburg Bridge) near Vicksburg | US 80 at the Alabama state line near Kewanee | 1926 | current | ||
 US 82 | 180.0 | 289.7 | US 82 at the Arkansas state line (Greenville Bridge) near Refuge | US 82 at the Alabama state line near New Hope | 1932 | current | ||
 US 84 | 179.2 | 288.4 | US 84 at the Louisiana state line (Natchez-Vidalia Bridge) near Natchez | US 84 at the Alabama state line near Waynesboro | 1926 | current | ||
 US 90 | 79.7 | 128.3 | US 90 at the Louisiana state line (East Pearl River) near Pearlington | US 90 at the Alabama state line near Pecan | 1926 | current | ||
 US 98 | 166.3 | 267.6 | US 61 at Washington | US 98 at the Alabama state line near Lucedale | 1933 | current | ||
 US 278 | 135.5 | 218.1 | US 278 at the Arkansas state line (Greenville Bridge) near Refuge | US 278 at the Alabama state line near Gattman | 1978 | current | ||
 US 425 | 2.9 | 4.7 | US 61 at Natchez, Mississippi | US 425 at the Louisiana state line (Natchez-Vidalia Bridge) near Natchez | 2005 | current | ||
 |
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 45 Alt. | 62.9 | 101.2 | US 45 in Brooksville | US 45/US 278 in Shannon | 1968 | current | Signed as both US 45A and US 45 Alternate | |
 US 51 Bus. | — | — | US 51 south of Crystal Springs | US 51 north of Crystal Springs | — | — | ||
| US 51 Bus. | — | — | US 51 south of McComb | US 51 north of McComb | — | — | Unsigned | |
| US 61 Bus. | — | — | US 61 south of Leland | US 61 north of Leland | — | — | ||
| US 61 Bus. | — | — | US 61 south of Natchez | US 61 north of Natchez | — | — | ||
| US 61 Bus. | — | — | US 61 south of Port Gibson | US 61 north of Port Gibson | — | — | ||
| US 61 Bus. | — | — | US 61 south of Vicksburg | US 61 north of Vicksburg | — | — | Conncurrent with MS 834 | |
Jackson is the capital of and the most populous city in the U.S. state of Mississippi. Along with Raymond, Jackson is one of two county seats for Hinds County. The city had a population of 153,701 at the 2020 census, a significant decline from 173,514, or 11.42%, since the 2010 census, representing the largest decline in population during the decade of any major U.S. city. Jackson is the anchor for the Jackson metropolitan statistical area, the largest metropolitan area located entirely in the state and the tenth-largest urban area in the Deep South. With a 2020 population of nearly 600,000, metropolitan Jackson is home to over one-fifth of Mississippi's population. The city sits on the Pearl River and is located in the greater Jackson Prairie region of Mississippi. Jackson is the only city in Mississippi with a population exceeding 100,000 people.
The Louisiana Purchase was the acquisition of the territory of Louisiana by the United States from the French First Republic in 1803. This consisted of most of the land in the Mississippi River's drainage basin west of the river. In return for fifteen million dollars, or approximately eighteen dollars per square mile, the United States nominally acquired a total of 828,000 sq mi now in the Central United States. However, France only controlled a small fraction of this area, most of which was inhabited by Native Americans; effectively, for the majority of the area, the United States bought the preemptive right to obtain Indian lands by treaty or by conquest, to the exclusion of other colonial powers.
The Mississippi River is the primary river and second-longest river of the largest drainage basin in the United States. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 miles (3,766 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km2), of which only about one percent is in Canada. The Mississippi ranks as the thirteenth-largest river by discharge in the world. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana.
The University of Mississippi is a public research university in Oxford, Mississippi, United States, with a medical center in Jackson. It is Mississippi's oldest public university and is the state's largest by enrollment.
Harrison County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 208,621. Its county seats are Biloxi and Gulfport. The county is named after U.S. President William Henry Harrison. Harrison County is part of the Gulfport-Biloxi metropolitan area. The county was severely damaged from both Hurricane Camille on August 17, 1969, and Hurricane Katrina on August 29, 2005, causing catastrophic effects.
Natchez, officially the City of Natchez, is the only city in and the county seat of Adams County, Mississippi, United States. The population was 14,520 at the 2020 census. Located on the Mississippi River across from Vidalia in Concordia Parish, Louisiana, Natchez was a prominent city in the antebellum years, a center of cotton planters and Mississippi River trade.
Biloxi is a city in Harrison County, Mississippi, United States. It lies on the Gulf Coast in southern Mississippi, bordering the city of Gulfport to its west. The adjacent cities are both designated as seats of Harrison County. The population of Biloxi was 49,449 at the 2020 census, making it the state's 4th most populous city. It is a principal city of the Gulfport–Biloxi metropolitan area, home to 416,259 residents in 2020. The area's first European settlers were French colonists.
Gulfport is the second-most populous city in the U.S. state of Mississippi after the state capital, Jackson. Along with Biloxi, Gulfport is the co-county seat of Harrison County and part of the Gulfport–Biloxi metropolitan area. As of the 2020 census, Gulfport has a population of 72,926; the metro area has a population of 416,259. Gulfport lies along the gulf coast of the United States in southern Mississippi, taking its name from its port on the Gulf Coast on the Mississippi Sound. It is home to the U.S. Navy Atlantic Fleet Seabees.
Oxford is the 14th most populous city in Mississippi, United States, and the county seat of Lafayette County, 75 miles (121 km) southeast of Memphis. A college town, Oxford surrounds the University of Mississippi or "Ole Miss". Founded in 1837, the city is named for Oxford, England.
Tupelo is a city in and the county seat of Lee County, Mississippi, United States. Founded in 1860, the population was 37,923 at the 2020 census. It is the 7th most populous city in Mississippi and is considered a commercial, industrial, and cultural hub of northern Mississippi.
Vicksburg is a historic city in Warren County, Mississippi, United States. It is the county seat. The population was 21,573 at the 2020 census. Located on a high bluff on the east bank of the Mississippi River across from Louisiana, Vicksburg was built by French colonists in 1719. The outpost withstood an attack from the native Natchez people. It was incorporated as Vicksburg in 1825 after Methodist missionary Newitt Vick. The area that is now Vicksburg was long occupied by the Natchez Native Americans as part of their historical territory along the Mississippi. The first Europeans who settled the area were French colonists who built Fort Saint Pierre in 1719 on the high bluffs overlooking the Yazoo River at present-day Redwood. They conducted fur trading with the Natchez and others, and started plantations. During the American Civil War, it was a key Confederate river-port, and its July 1863 surrender to Ulysses S. Grant, along with the concurrent Battle of Gettysburg, marked the turning-point of the war.
U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage, then continued to Thunder Bay, Canada, as Ontario Highway 61. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.
U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.
Mississippi State University for Agriculture and Applied Science, commonly known as Mississippi State University (MSU), is a public land-grant research university in Mississippi State, Mississippi. It is classified among "R1: Doctoral Universities – Very High Research Activity" and has a total research and development budget of $239.4 million, the largest in Mississippi.
U.S. Route 98 is an east–west United States Highway in the Southeastern United States that runs from western Mississippi to southern Florida. It was established in 1933 as a route between Pensacola and Apalachicola, Florida, and has since been extended westward into Mississippi and eastward across the Florida Peninsula. It runs along much of the Gulf Coast between Mobile, Alabama, and Crystal River, Florida, including extensive sections closely following the coast between Mobile and St. Marks, Florida. The highway's western terminus is with US 84 in Bude, Mississippi. Its eastern terminus is Palm Beach, Florida, at State Road A1A (SR A1A) near the Mar-a-Lago resort.
Mississippi is a state in the Southeastern region of the United States. It borders Tennessee to the north, Alabama to the east, the Gulf of Mexico to the south, Louisiana to the southwest, and Arkansas to the northwest. Mississippi's western boundary is largely defined by the Mississippi River, or its historical course. Mississippi is the 32nd largest by area and 35th-most populous of the 50 U.S. states and has the lowest per-capita income. Jackson is both the state's capital and largest city. Greater Jackson is the state's most populous metropolitan area, with a population of 591,978 in 2020. Other major cities include Gulfport, Southaven, Hattiesburg, Biloxi, Olive Branch, Tupelo, Meridian, and Greenville.
The following outline is provided as an overview of and topical guide to the U.S. state of Mississippi:
The 2020 United States Senate election in Mississippi was held on November 3, 2020, to elect a member of the United States Senate to represent the State of Mississippi, concurrently with the 2020 U.S. presidential election, as well as other elections to the United States Senate, elections to the United States House of Representatives and various state and local elections.
