   Standard route shields | |
| Highway names | |
|---|---|
| Interstates | Interstate X (I-X) |
| US Highways | U.S. Route X (US X) |
| State | Mississippi Highway X (MS X) |
| System links | |
In the U.S. state of Mississippi, U.S. Routes are maintained by the Mississippi Department of Transportation (MDOT).
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 11 | 173.1 | 278.6 | I-59 at Nicholson | US 11 at the Alabama state line near Kewanee | 1926 | current | ||
 US 45 | 273.5 | 440.2 | US 45 at the Alabama state line near State Line | US 45 at the Tennessee state line near Wenesoga | 1926 | current | ||
 US 49 | 204.2 | 328.6 | US 90 at Gulfport | US 49E/US 49W at Yazoo City | 1926 | current | Southern segment | |
| US 49 | 40.9 | 65.8 | US 49E/US 49W at Tutwiler | US 49 at the Arkansas state line (Helena Bridge) near Helena | 1926 | current | Northern segment | |
 US 49E | 85.862 | 138.181 | US 49 & US 49W at Yazoo City | US 49 & US 49W at Tutwiler | 1926 | current | ||
 US 49W | 81.894 | 131.796 | US 49 & US 49E at Yazoo City | US 49 & US 49E at Tutwiler | 1926 | current | ||
 US 51 | 267.2 | 430.0 | US 51 at the Louisiana state line near Osyka | US 51 at the Tennessee state line near Horn Lake | 1926 | current | ||
 US 61 | 299.8 | 482.5 | US 61 at the Louisiana state line near Woodville | US 61 at the Tennessee state line near Lake View | 1926 | current | ||
 US 65 | 2.9 | 4.7 | US 61 in Natchez | US 65 at the Louisiana state line near Natchez | 1926 | 2005 | Entirely replaced by US 425 | |
 US 72 | 89.9 | 144.7 | US 72 at the Tennessee state line near Barton | US 72 at the Alabama state line near Oldham | 1926 | current | ||
 US 78 | 118.0 | 189.9 | US 78 at the Tennessee state line near Olive Branch | US 78 at the Alabama state line near Tremont | 1926 | current | ||
 US 80 | 157 | 253 | US 80 at the Louisiana state line (Vicksburg Bridge) near Vicksburg | US 80 at the Alabama state line near Kewanee | 1926 | current | ||
 US 82 | 180.0 | 289.7 | US 82 at the Arkansas state line (Greenville Bridge) near Refuge | US 82 at the Alabama state line near New Hope | 1932 | current | ||
 US 84 | 179.2 | 288.4 | US 84 at the Louisiana state line (Natchez-Vidalia Bridge) near Natchez | US 84 at the Alabama state line near Waynesboro | 1926 | current | ||
 US 90 | 79.7 | 128.3 | US 90 at the Louisiana state line (East Pearl River) near Pearlington | US 90 at the Alabama state line near Pecan | 1926 | current | ||
 US 98 | 166.3 | 267.6 | US 61 at Washington | US 98 at the Alabama state line near Lucedale | 1933 | current | ||
 US 278 | 135.5 | 218.1 | US 278 at the Arkansas state line (Greenville Bridge) near Refuge | US 278 at the Alabama state line near Gattman | 1978 | current | ||
 US 425 | 2.9 | 4.7 | US 61 at Natchez, Mississippi | US 425 at the Louisiana state line (Natchez-Vidalia Bridge) near Natchez | 2005 | current | ||
 |
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 45 Alt. | 62.9 | 101.2 | US 45 in Brooksville | US 45/US 278 in Shannon | 1968 | current | Signed as both US 45A and US 45 Alternate | |
 US 51 Bus. | — | — | US 51 south of Cyrstal Springs | US 51 north of Cyrstal Springs | — | — | ||
| US 51 Bus. | — | — | US 51 south of McComb | US 51 north of McComb | — | — | Unsigned | |
| US 61 Bus. | — | — | US 61 south of Leland | US 61 north of Leland | — | — | ||
| US 61 Bus. | — | — | US 61 south of Natchez | US 61 north of Natchez | — | — | ||
| US 61 Bus. | — | — | US 61 south of Port Gibson | US 61 north of Port Gibson | — | — | ||
| US 61 Bus. | — | — | US 61 south of Vicksburg | US 61 north of Vicksburg | — | — | Conncurrent with MS 834 | |
The Choctaw are a Native American people originally based in the Southeastern Woodlands, in what is now Alabama and Mississippi. Their Choctaw language is a Western Muskogean language. Today, Choctaw people are enrolled in three federally recognized tribes: the Choctaw Nation of Oklahoma, Mississippi Band of Choctaw Indians, and Jena Band of Choctaw Indians in Louisiana.
Jackson is the capital of and the most populous city in the U.S. state of Mississippi. Along with Raymond, Jackson is one of two county seats for Hinds County. The city had a population of 153,701 at the 2020 census, a significant decline from 173,514, or 11.42%, since the 2010 census, representing the largest decline in population during the decade of any major U.S. city. Jackson is the anchor for the Jackson metropolitan statistical area, the largest metropolitan area located entirely in the state and the tenth-largest urban area in the Deep South. With a 2020 population of nearly 600,000, metropolitan Jackson is home to over one-fifth of Mississippi's population. The city sits on the Pearl River and is located in the greater Jackson Prairie region of Mississippi. Jackson is the only city in Mississippi with a population exceeding 100,000 people.
The Louisiana Purchase was the acquisition of the territory of Louisiana by the United States from the French First Republic in 1803. This consisted of most of the land in the Mississippi River's drainage basin west of the river. In return for fifteen million dollars, or approximately eighteen dollars per square mile, the United States nominally acquired a total of 828,000 sq mi in Middle America. However, France only controlled a small fraction of this area, most of which was inhabited by Native Americans; effectively, for the majority of the area, the United States bought the preemptive right to obtain Indian lands by treaty or by conquest, to the exclusion of other colonial powers.
The Mississippi River is the primary river, and second-longest river, of the largest drainage basin in the United States. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 miles (3,766 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km2), of which only about one percent is in Canada. The Mississippi ranks as the thirteenth-largest river by discharge in the world. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana.
The University of Mississippi is a public research university that is located adjacent to Oxford, Mississippi, and has a medical center in Jackson. It is Mississippi's oldest public university and it is the second largest by enrollment.
Natchez, officially the City of Natchez, is the only city in and the county seat of Adams County, Mississippi, United States. The population was 14,520 at the 2020 census. Located on the Mississippi River across from Vidalia in Concordia Parish, Louisiana, Natchez was a prominent city in the antebellum years, a center of cotton planters and Mississippi River trade.
Biloxi is a city in Harrison County, Mississippi, United States. It lies on the Gulf Coast in southern Mississippi thirteen miles east of Gulfport along US-90. The adjacent cities are both designated as seats of Harrison County. The population of Biloxi was 49,449 at the 2020 census, making it the state's 4th most populous city. It is a principal city of the Gulfport–Biloxi metropolitan area, home to 416,259 residents in 2020. The area's first European settlers were French colonists.
Gulfport is the 2nd most populous city in the U.S. state of Mississippi after the state capital, Jackson. Along with Biloxi, Gulfport is the co-county seat of Harrison County and the larger of the two principal cities of the Gulfport–Biloxi metropolitan area. As of the 2020 census, the city of Gulfport had a total population of 72,926, with 416,259 residents in its metro area. The city lies along the Gulf Coast in southern Mississippi, taking its name from its port on the Mississippi Sound. It is also home to the U.S. Navy Atlantic Fleet Seabees.
Laurel is a city in and the second county seat of Jones County, Mississippi, United States. As of the 2020 census, the city had a population of 17,161. Laurel is northeast of Ellisville, the first county seat, which contains the first county courthouse. It has the second county courthouse, as Jones County has two judicial districts. Laurel is the headquarters of the Jones County Sheriff's Department, which administers in the county. Laurel is the principal city of a micropolitan statistical area named for it. Major employers include Howard Industries, Sanderson Farms, Masonite International, Family Health Center, Howse Implement, Thermo-Kool, and South Central Regional Medical Center. Laurel is home to the Lauren Rogers Museum of Art, Mississippi's oldest art museum, established by the family of Lauren Eastman Rogers.
Oxford is the 14th most populous city in Mississippi, and the county seat of Lafayette County, 75 miles (121 km) southeast of Memphis. A college town, the University of Mississippi or "Ole Miss" is adjacent to the city. Founded in 1837, it is named for Oxford, England.
Tupelo is a city in and the county seat of Lee County, Mississippi, United States. With an estimated population of 38,300, Tupelo is the 7th most populous city in Mississippi and is considered a commercial, industrial, and cultural hub of North Mississippi.
Starkville is a city in, and the county seat of, Oktibbeha County, Mississippi, United States. Mississippi State University is a land-grant institution and is located partially in Starkville but primarily in an adjacent unincorporated area designated by the United States Census Bureau as Mississippi State, Mississippi. The population was 25,653 in 2019. Starkville is the most populous city of the Golden Triangle region of Mississippi. The Starkville micropolitan statistical area includes all of Oktibbeha County.
Vicksburg is a historic city in Warren County, Mississippi, United States. It is the county seat. The population was 21,573 at the 2020 census. Located on a high bluff on the east bank of the Mississippi River across from Louisiana, Vicksburg was built by French colonists in 1719. The outpost withstood an attack from the native Natchez people. It was incorporated as Vicksburg in 1825 after Methodist missionary Newitt Vick. The area that is now Vicksburg was long occupied by the Natchez Native Americans as part of their historical territory along the Mississippi. The first Europeans who settled the area were French colonists who built Fort Saint Pierre in 1719 on the high bluffs overlooking the Yazoo River at present-day Redwood. They conducted fur trading with the Natchez and others, and started plantations. During the American Civil War, it was a key Confederate river-port, and its July 1863 surrender to Ulysses S. Grant, along with the concurrent Battle of Gettysburg, marked the turning-point of the war.
Medgar Wiley Evers was an American civil rights activist and the NAACP's first field secretary in Mississippi, who was assassinated by Byron De La Beckwith. Evers, a decorated U.S. Army combat veteran who had served in World War II, was engaged in efforts to overturn segregation at the University of Mississippi, end the segregation of public facilities, and expand opportunities for African Americans including the enforcement of voting rights.
U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.
Mississippi State University for Agriculture and Applied Science, commonly known as Mississippi State University (MSU), is a public land-grant research university adjacent to Starkville, Mississippi. It is classified among "R1: Doctoral Universities – Very High Research Activity" and has a total research and development budget of $239.4 million, the largest in Mississippi.
Mississippi is a state in the Southeastern region of the United States, bordered to the north by Tennessee; to the east by Alabama; to the south by the Gulf of Mexico; to the southwest by Louisiana; and to the northwest by Arkansas. Mississippi's western boundary is largely defined by the Mississippi River, or its historical course. Mississippi is the 32nd largest by area and 35th-most populous of the 50 U.S. states and has the lowest per-capita income in the United States. Jackson is both the state's capital and largest city. Greater Jackson is the state's most populous metropolitan area, with a population of 591,978 in 2020.
The 2020 United States Senate election in Mississippi was held on November 3, 2020, to elect a member of the United States Senate to represent the State of Mississippi, concurrently with the 2020 U.S. presidential election, as well as other elections to the United States Senate, elections to the United States House of Representatives and various state and local elections.
