Interstate 85 (I-85) is a major Interstate Highway in the Southeastern United States. Its southern terminus is at an interchange with I-65 in Montgomery, Alabama; its northern terminus is an interchange with I-95 in Petersburg, Virginia, near Richmond. It is nominally north–south as it carries an odd number, but it is physically oriented northeast–southwest and covers a larger east–west span than north–south. While most Interstates that end in a "5" are cross-country, I-85 is primarily a regional route serving five southeastern states: Virginia, North Carolina, South Carolina, Georgia, and Alabama.
U.S. Route 45 is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,297 miles (2,087 km).
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
U.S. Route 82 is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern Arkansas, US 82 eventually became a 1,625-mile-long (2,615 km) route extending from the White Sands of New Mexico to Georgia's Atlantic coast.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 65 is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana. The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota. Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway.
U.S. Highway 151 (US 151) is a United States Numbered Highway that runs through the states of Iowa and Wisconsin. The southern terminus for US 151 is at a junction with Interstate 80 (I-80) in Iowa County, Iowa, and its northern terminus is at Manitowoc, Wisconsin. The route, from south to north follows a northeasterly path through the two states.
U.S. Route 43 (US 43) is a 410-mile-long (660 km) north–south United States Highway in the Southern states of Alabama and Tennessee. It travels from Prichard, Alabama, to Columbia, Tennessee. The highway's southern terminus is in Prichard, at an intersection with US 90, and its northern terminus is in Columbia at an intersection with US 31/US 412/US 412 Bus.
U.S. Route 264 (US 264) is an east–west United States Highway located completely within the U.S. state of North Carolina, running for 215.7 miles (347.1 km). Its western terminus is located at Interstate 87 (I-87), I-440, and US 64 in Raleigh. US 264 is a freeway between Raleigh and Wilson, with segments running concurrently with I-87, I-587, I-795, and US 64. The highway is largely parallel to I-587 between Wilson and Greenville and primarily serves smaller communities such as Saratoga and Farmville. East of Greenville, US 264 is an important highway connecting communities such as Washington, Belhaven, Swan Quarter, and Engelhard. The eastern terminus of US 264 is located at US 64 in Manns Harbor.
U.S. Route 167 is a north-south United States Highway within the U.S. states of Louisiana and Arkansas. It runs for 500 miles (800 km) from Ash Flat, Arkansas at U.S. Route 62/U.S. Route 412 to Abbeville, Louisiana at Louisiana Highway 14. It goes through the cities of Little Rock, Arkansas, Alexandria, Louisiana, and Lafayette, Louisiana.
U.S. Route 278 is a parallel route of US 78. It currently runs for 1,074 miles (1,728 km) from Hilton Head Island, South Carolina, to Wickes, Arkansas at US 71/US 59, passing through five states in the process. Landmarks along its route include the Department of Energy's Savannah River Site in South Carolina and the Tennessee-Tombigbee Waterway in eastern Mississippi. There are several universities located along the highway including Georgia State University, the University of Mississippi, and the University of Arkansas at Monticello.
Mississippi Highway 12 is a state highway in northern Mississippi that runs 198.7 miles (319.8 km) west–east from MS 1 west of Hollandale at the Mississippi River to State Route 18 at the Alabama state line northeast of Columbus. MS 12 traverses three major regions of the state, the Mississippi Delta, the North Central Hills, and the Golden Triangle.
Mississippi Highway 182 designates the old two-lane highway for U.S. Route 82 (US 82) where the current US 82 occupies a new right-of-way. Some of the towns with a segment of MS 182 are Winona, Kilmichael, Eupora, Mayhew, Starkville, and Columbus.
Mississippi Highway 69 is a state highway in eastern Mississippi. The route starts at the Alabama state line, and travels northwestward to Columbus. MS 69 then goes through downtown Columbus, and ends at U.S. Route 45 and US 82 in the west side of the town. Before the road was designated as MS 69 in 1941, it was a gravel road from Columbus to the state line. The road was paved in asphalt in 1953. In 1992, US 82 was realigned, and MS 69 was extended through Columbus to its current northern terminus.
Mississippi Highway 50 is a state highway in Mississippi. It generally follows an east/west track for 60 miles (97 km) and runs from MS 9 in Walthall, Mississippi, east to the Alabama state line east of Columbus. MS 50 serves the following Mississippi counties: Lowndes, Clay, and Webster.
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at US 67 /Arkansas Highway 226 (AR 226) near Cash and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 in Memphis, Tennessee.
U.S. Route 34 (US 34) is an east–west highway in the state of Illinois that runs from the Iowa state line at Gulfport, west of Galesburg, to Illinois Route 43 (IL 43) and Historic U.S. Route 66 at Harlem Avenue in Berwyn. The entire highway in Illinois is named the Walter Payton Memorial Highway after Pro Football Hall of Famer Walter Payton, who wore #34 for the Chicago Bears. The highway is 211.37 miles (340.17 km) long within the state.
U.S. Route 40 (US 40) runs east–west across south central Illinois for 159.8 miles (257.2 km). US 40 enters the state from Missouri across the Poplar Street Bridge over the Mississippi River at East St. Louis concurrent with Interstate 55 (I-55) and I-64 and exits just south of State Line, Indiana, running concurrently with I-70. For the majority of its route through Illinois, US 40 follows the National Road, including the route's initial western terminus at Vandalia.
U.S. Highway 76 (US 76) is a U.S. Highway running from Chattanooga, Tennessee to Wrightsville Beach, North Carolina. In North Carolina the highway runs for 80.4 miles (129.4 km) in the southeastern region of the state. US 76 enters the state from South Carolina south of Fair Bluff in Columbus County. Travelling in an eastward direction, US 76 meets US 74 in Chadbourn. The two highways run concurrently for 50.4 miles (81.1 km) between Chadbourn and Wilmington. US 76 runs concurrently with US 17 along much of its Wilmington routing, until once again meeting US 74. US 76 and US 74 run concurrently for 1.4 miles (2.3 km) until reaching Wrightsville Beach. US 76 reaches its eastern terminus on the south side of Wrightsville Beach, at an intersection with Water Street.
U.S. Highway 82 in Arkansas is a major east–west arterial highway across the state's lowest tier of counties. It enters Arkansas from Texas, concurrent with US Highway 67, at a junction with US Highway 71 on the border between Texarkana, Texas and Texarkana, Arkansas. The route leaves Arkansas on the Lake Village Bridge over the Mississippi River near Lake Village, crossing into Mississippi.
US 82 / US 278 at the Arkansas state line
US 82 at the Alabama state line
