U.S. Route 72 (US 72) is an east–west United States highway that travels for 317.811 miles (511.467 km) from southwestern Tennessee, throughout North Mississippi, North Alabama, and southeastern Tennessee. The highway's western terminus is in Memphis, Tennessee and its eastern terminus is in Chattanooga. It is the only U.S. Highway to begin and end in the same state, yet pass through other states in between. Prior to the U.S. Highway system signage being posted in 1926, the entire route was part of the Lee Highway.
Mississippi Highway 182 designates the old two-lane highway for U.S. Route 82 (US 82) where the current US 82 occupies a new right-of-way. Some of the towns with a segment of MS 182 are Winona, Kilmichael, Eupora, Mayhew, Starkville, and Columbus.
Mississippi Highway 365 is a state highway in northeastern Mississippi. The route starts at MS 30 in Burton and travels northward. It travels into Burnsville and intersects U.S. Route 72. MS 365 continues northeastward and ends at MS 25 west of Pickwick Lake. The route was designated by 1950, connecting from MS 30 to MS 364. It was extended northward to MS 356 around 1958 and was completely paved by 1964. The route replaced parts of MS 356 in 1965, and its northern terminus was changed to MS 25.
Mississippi Highway 4 runs east–west from an intersection in the community of Fox Island west of Tunica, Mississippi, near the border with Arkansas, to MS 25 in Tishomingo County, Mississippi. It travels a distance of 159.8 miles (257.2 km), serving Tunica, Tate, Marshall, Benton, Tippah, Prentiss, and Tishomingo counties.
Mississippi Highway 172 (MS 172) is a state highway located in Tishomingo County, Mississippi. The route runs 12.074 mi (19.431 km) from U.S. Route 72 (US 72) near Burnsville east to US 72 near Oldham, just west of the Alabama border. The route is a two-lane undivided road its entire length and runs mostly through wooded areas. It also passes through the town of Iuka, where it has an intersection with MS 25.
Mississippi Highway 145 (MS 145) is the designation for the parts of the old U.S. Route 45 (US 45) roadbed that the state continues to maintain or has designated. Those ten sections travel through Waynesboro, near Boice, through Shubuta, from De Soto to Meridian, through Shuqualak, through Macon, through Aberdeen, through Nettleton, from Shannon to Booneville, and through Corinth.
Mississippi Highway 5 is a state highway in Benton County, Mississippi, United States. It runs 24.3 mi (39.107 km) from MS 178 in Hickory Flat north to U.S. Route 72 to the south of Michigan City. The route runs through the Holly Springs National Forest for much of its length and passes through Ashland. To the south of Ashland, MS 5 has a concurrency with MS 4. The MS 5 designation was first used by 1932 for an unpaved road between Hickory Flat and the Tennessee border in Michigan City. In 1943, the northern terminus was cut back to US 72. MS 5 was completely paved by 1951 and has retained its current alignment since then.
Mississippi Highway 9W is a 20.3-mile (32.7 km) long state highway located in northern Mississippi. The southern terminus of the route is at MS 9 north of Bruce in Calhoun County while the northern terminus is at MS 7 south of Oxford in Lafayette County. The route is a two-lane undivided road its entire length and passes through rural areas of woods and farms. Along the way, MS 9W intersects MS 315 in Paris. MS 9W was designated to follow its current alignment in 1956 and was fully paved from a gravel road by 1960.
Mississippi Highway 24 is a state highway in Mississippi, United States. The highway runs 76.0 miles (122.3 km) from Fort Adams east to an interchange with Interstate 55 (I-55) and U.S. Highway 98 in McComb. The roadway passes through Wilkinson, Amite, and Pike counties, serving the communities of Woodville, Centreville, Gloster, and Liberty. MS 24 has concurrencies with MS 33 between Centerville and Gloster and MS 48 from Liberty to west of McComb.
U.S. Route 45 Alternate is a 62.9-mile-long (101.2 km) alternate route of US 45 in northeastern Mississippi, running from Brooksville, through West Point, to Shannon, which lies just south of Tupelo. Excluding the route through West Point, the entire length of US 45 Alternate is a four-lane divided expressway, with interchanges at most major junctions.
North Carolina Highway 231 (NC 231) is a 25.4-mile-long (40.9 km) primary state highway in the U.S. state of North Carolina. NC 231 travels through Wake County, Johnston County, and Nash County between its southern terminus at US 64 Business in Wendell and its northern terminus at US 64 Alternate/NC 98 near Spring Hope. Throughout Wake County and Johnston County, NC 231 primarily follows a southeast-northwest alignment. Entering into Nash County, NC 231 turns to follow a northerly alignment until reaching its northern terminus. NC 231 serves the towns of Wendell, Middlesex, and Spring Hope.
Mississippi Highway 366 is a short highway in northeastern Mississippi. The road starts at MS 25 in Belmont, and travels southeastward through Golden to the Alabama state border. The route was created in 1958, and hasn't changed significantly since.
Mississippi Highway 389 is a state highway that runs from south to north in the U.S. State of Mississippi. MS 389 currently exists in two sections. The southern section begins at MS 182 in Starkville. The road travels north out of the city, and crosses U.S. Route 82 and MS 15. North of Starkville, the route continues northwestwards and ends at the Oktibbeha–Clay county line south of Pheba. The northern section starts at MS 46 west of Montpelier, and it travels north to cross the Natchez Trace Parkway in Chickasaw County. MS 389 ends at MS 8 in Houston.
Mississippi Highway 433 (MS 433) is a state highway in western Mississippi consisting of two segments. The western segment, running entirely in Sharkey County is unsigned and runs for about 10.5 miles (16.9 km). The eastern segment, at a length of 45.3 miles (72.9 km), runs from Satartia in Yazoo County to rural Holmes County.
Mississippi Highway 371 (MS 371) is a 44-mile-long (71 km) state highway in northeastern Mississippi running from MS 6 near Amory to MS 4 near New Site. The highway has been in existence since 1950 but it has followed its current alignment since 1965.
Mississippi Highway 503 (MS 503) is a 41-mile-long (66 km) state highway in eastern Mississippi running from MS 528 near its junction with Interstate 59 (I-59) outside of Heidelberg to MS 15 in Decatur. The highway has been in existence since 1951 and became designated MS 503 by 1955.
Mississippi Highway 397 (MS 397) is a 33+1⁄2-mile-long (53.9 km) state highway in eastern Mississippi. Running generally in a southeast to northwest direction, it is signed north--south traveling from the De Kalb vicinity at MS 16 to Louisville at MS 14.
Mississippi Highway 487 (MS 487) is a state highway mostly within Leake County, Mississippi that travels in a arc-shape for about 26 miles (42 km). The highway is signed north-south though the overall direction runs from west to east from Lena to Sebastopol, Scott County; its purported northern terminus is lower in latitude than its southern terminus.
Mississippi Highway 547 (MS 547) is a state highway in southwestern Mississippi. The highway runs about 25 miles (40 km) long on a southeast to northwest direction, signed as a north–south route. It connects MS 28 at Allen with Pattison and U.S. Route 61 (US 61) in southern Port Gibson.
Mississippi Highway 588 (MS 588) is a 21-mile-long (34 km) state highway running from U.S. Route 84 (US 84) outside of Collins to MS 29 in Ellisville in southern Mississippi.
I-55 in Jackson 
SR 57 near North Crossroads 
