Lee is a county in Mississippi. As of the 2010 census, the population was 82,910. The county seat is Tupelo. Lee County is included in the Tupelo Micropolitan Statistical Area.
U.S. Route 278 is a parallel route of US 78. It currently runs for 1,074 miles (1,728 km) from Hilton Head Island, South Carolina, to Wickes, Arkansas at US 71/US 59, passing through five states in the process. Landmarks along its route include the Department of Energy's Savannah River Site in South Carolina and the Tennessee-Tombigbee Waterway in eastern Mississippi. There are several universities located along the highway including Georgia State University, the University of Mississippi, and the University of Arkansas at Monticello.
Interstate 22 (I-22) is a 202.5-mile-long (325.9 km) Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway System. Designated in 2012, I-22 follows the route of the older U.S. Route 78 (US 78). The freeway mainly spans rural areas and passes numerous small towns along its route, including Fulton, Tupelo, New Albany, and Holly Springs in Mississippi; and Jasper, Winfield, and Hamilton in Alabama.
Mississippi Highway 6 (MS 6) runs east–west from MS 161 in Lyon, east to MS 25 near Amory. It travels approximately 139 miles (224 km), serving Coahoma, Quitman, Panola, Lafayette, Pontotoc, Lee, and Monroe Counties. West of Tupelo, it is concurrent with US 278. Points of interest along the route include the University of Mississippi, Trace State Park, Natchez Trace Parkway, the Elvis Presley Birthplace, and Tombigbee State Park.
The Appalachian Development Highway System (ADHS) is a series of highway corridors in the Appalachia region of the eastern United States. The routes are designed as local and regional routes for improving economic development in the historically isolated region. It was established as part of the Appalachian Regional Development Act of 1965, and has been repeatedly supplemented by various federal and state legislative and regulatory actions. The system consists of a mixture of state, U.S., and Interstate routes. The routes are formally designated as "corridors" and assigned a letter. Signage of these corridors varies from place to place, but where signed are often done so with a distinctive blue-colored sign.
Mississippi Highway 145 (MS 145) is the designation for the parts of the old U.S. Route 45 (US 45) roadbed that the state continues to maintain or has designated. Those ten sections travel through Waynesboro, near Boice, through Shubuta, from De Soto to Meridian, through Shuqualak, through Macon, through Aberdeen, through Nettleton, from Shannon to Booneville, and through Corinth.
U.S. Route 78 is an east–west United States highway that runs for 715 miles (1,151 km) from Memphis, Tennessee, to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 is concurrent with Interstate 22. The highway's western terminus is at U.S. Route 64/U.S. Route 70/U.S. Route 79 in Memphis, Tennessee, and its eastern terminus is on Line Street, in Charleston, South Carolina. One of its related routes, US 278, is actually longer in length than US 78.
Mississippi Highway 23 is a state highway in Mississippi. The route starts at MS 25 in the town of Smithville. It travels northeastward through the forests of eastern Itawamba County. The highway intersects Interstate 22 (I-22) and U.S. Route 78 in Tremont. MS 23 ends at the Mississippi–Alabama state line, just west of Red Bay.
State Route 24 (SR 24) is a 71-mile-long (114 km) state highway in the northwestern and north-central part of the state. The western terminus of the route is near Red Bay at the Mississippi state line, where it continues as Mississippi Highway 76. The eastern terminus of the route is near the junction with SR 67 at Decatur, where it continues for 2 miles as Moulton Street. Moulton Street ends east of US 31. The route is one of several segments that comprises Corridor V of the Appalachian Development Highway System. Once completed, Corridor V will provide a continuous route between Batesville, Mississippi and Chattanooga, Tennessee.
U.S. Route 45 Alternate is a 62.9-mile-long (101.2 km) alternate route of US 45 in northeastern Mississippi, running from Brooksville, through West Point, to Shannon, which lies just south of Tupelo. Excluding the route through West Point, the entire length of US 45 Alternate is a four-lane divided expressway, with interchanges at most major junctions.
Mississippi Highway 178 (MS 178), or simply "Old 78", is a 119.1-mile-long (191.7 km) east-west state highway across the northern portion of the state of Mississippi. It is the former alignment of U.S. Route 78 (US 78), used from the 1940s until the 1990s. With the exception of a break at the Tennessee-Tombigbee Waterway in Fulton, MS 178 is a complete route from Memphis, Tennessee, to the Alabama state line.
Mississippi Highway 41 (MS 41) is a state highway in northeastern Mississippi. The route starts at U.S. Route 45 and US 278 north of Wren and travels westwards. It then intersects US 45 Alt. east of Okolona. The road enters Okolona, and intersects MS 32 and MS 245. MS 41 then turns northwest and travels toward Pontotoc. Once inside the city, the route turns north at MS 15 and travels through downtown Pontotoc. MS 41 ends at its intersection with MS 9 and MS 338. The route that became MS 41 was first used as an Indian trail. The route was designated by 1932 from Amory to Pontotoc, and it was truncated from Amory to US 45 by 1955. The entirety of MS 41 was paved by 1958.
Mississippi Highway 334 is a 27.772-mile-long (44.695 km) west–east state highway in the North Central Hills region of northern Mississippi, connecting Oxford, through Toccopola, to MS 9 in Springville.
Mississippi Highway 336 is a 15.778-mile-long (25.392 km) west–east state highway in the North Central Hills region of northern Mississippi, connecting Lafayette Springs, through Thaxton, to Pontotoc. It is generally a narrow two-lane route.
Mississippi Highway 342, also known as Black Zion Road, is a 7.793-mile-long (12.542 km) west–east state highway in eastern Pontotoc County, Mississippi, connecting MS 41 near Pontotoc to West Main Street east of Pontotoc. It is generally a narrow two-lane route.
Mississippi Highway 345 is a 9.272-mile-long (14.922 km) north–south state highway in Pontotoc County, Mississippi, connecting the city of Pontotoc with the town of Ecru.
Mississippi Highway 346, also known as Hurricane Road, is a 9.644-mile-long (15.521 km) west–east state highway in Pontotoc County, Mississippi, connecting the community of Esperanza with MS 15 and the town of Ecru. It is generally a narrow two-lane route.
Mississippi Highway 338 is a 11.943-mile-long (19.220 km) east-west state Highway in Pontotoc County, Mississippi. It serves as a business loop of U.S. Route 278 /MS 6 through the city of Pontotoc.
Mississippi Highway 355 is a 11.9-mile-long (19.2 km) north–south state highway in Pontotoc and Union counties. It connects the town of Thaxton with the town of New Albany.
MS 23 near Red Bay 
SR 24 at the Alabama state line
