Mississippi Highway 69 is a state highway in eastern Mississippi. The route starts at the Alabama state line, and travels northwestward to Columbus. MS 69 then goes through downtown Columbus, and ends at U.S. Route 45 and US 82 in the west side of the town. Before the road was designated as MS 69 in 1941, it was a gravel road from Columbus to the state line. The road was paved in asphalt in 1953. In 1992, US 82 was realigned, and MS 69 was extended through Columbus to its current northern terminus.
Mississippi Highway 364 is a state highway in northeastern Mississippi, separated in two segments. The route starts at MS 30 southeast of Booneville and travels northeastward. The road travels through Altitude and ends at MS 365 in Cairo. The other segment begins in Holcut and travels eastward to its terminus at MS 25 at Midway. The route was designated in 1950, from a former segment of MS 30 between MS 365 and MS 25. The route was extended southwestwards to MS 30 around 1960, and the highway was completely paved by 1984. The section of MS 364 near the Tennessee–Tombigbee Waterway were removed by the same year, and another section from MS 365 to the waterway was removed ten years later.
Mississippi Highway 2 is a designation for two highways in northern Mississippi. The westernmost segment starts at MS 5 in Hickory Flat, and ends at MS 15 and MS 368 in Blue Mountain. The eastern segment starts at MS 4 near Ripley and it travels northeastwards towards Corinth. The route becomes concurrent with U.S. Route 72 and US 45 in Corinth, and ends at the Tennessee state line. The road continues as Tennessee State Route 22. The route was designated around 1932, from the state line near Mount Pleasant to the state line near Corinth. The section west of Corinth became a part of US 72 by 1935, and the route was extended southwestwards to Hickory Flat by 1958.
Mississippi Highway 554 is a short highway near Natchez, Mississippi. The route starts at MS 555, and travels eastward. The road intersects the entrance to Natchez–Adams County Airport before ending at U.S. Route 61. The route was designated in 1957, and it included a separate route in southern Adams County. MS 554 was temporarily removed from the highway system in 1967, but was added back in 1973.
Mississippi Highway 450 is a highway in western Mississippi. Its western terminus is at MS 1 south of Benoit. The route travels east to its eastern terminus at U.S. Route 61 and US 278. It was designated in 1956, starting at MS 1 south of Scott, and ending at Choctaw. Starting in 1962, the section near Stringtown was rerouted significantly. The last realignment was in 1974, where the section near Stringtown was straightened, and US 61 moved east of Choctaw.
Mississippi Highway 306 is a state highway in northern Mississippi. The route starts at U.S. Route 51 in Coldwater, and it travels eastward to an interchange at Interstate 55 (I-55) on the northern edge of the town. The road continues eastward across northern Tate County and ends at MS 305 near Independence. MS 306 was designated in 1952, and it was constructed in 1953 from US 51 to MS 305. The route was paved in asphalt by 1956, and an interchange was built at I-55 by 1967.
Mississippi Highway 844 is a short highway near Crystal Springs, Mississippi. The route starts at Interstate 55 (I-55), and connects to U.S. Route 51 (US 51) east of the interstate highway. The road that became MS 844 was constructed around 1967, and was hidden in maps by 1974. Instead, a new loop near Crystal Springs was created. The route reappeared by 1998, and the section of MS 844 east of US 51 was transferred to the county by 2005.
Mississippi Highway 37 is a state highway in central Mississippi. The route starts at U.S. Route 84 near Collins. The road travels northward through the town of Taylorsville, crossing from Covington County to Smith County. MS 37 turns northwestward and ends at MS 35 in Raleigh. The road first existed as part of MS 35, and it became a spur route of MS 35 by 1941. It was renumbered as MS 37 by 1950, and fully paved by 1952.
Mississippi Highway 498 is a state highway in eastern Mississippi. The highway starts at U.S. Route 45 near Porterville, and it travels eastward from its western terminus. One mile (1.6 km) later, MS 498 ends near a railroad crossing west of Porterville, and the road continues as Porterville–Alabama Road. The route was designated around 1957, from US 45 to the Alabama–Mississippi state line. MS 498 was truncated to Porterville by 1970.
Mississippi Highway 41 (MS 41) is a state highway in northeastern Mississippi. The route starts at U.S. Route 45 and US 278 north of Wren and travels westwards. It then intersects US 45 Alt. east of Okolona. The road enters Okolona, and intersects MS 32 and MS 245. MS 41 then turns northwest and travels toward Pontotoc. Once inside the city, the route turns north at MS 15 and travels through downtown Pontotoc. MS 41 ends at its intersection with MS 9 and MS 338. The route that became MS 41 was first used as an Indian trail. The route was designated by 1932 from Amory to Pontotoc, and it was truncated from Amory to US 45 by 1955. The entirety of MS 41 was paved by 1958.
Mississippi Highway 388 is a state highway in eastern Mississippi. The route starts at the intersection of U.S. Route 45 Alternate and MS 852 in Brooksville, and it travels east to US 45 soon after. The route intersects MS 792 near Cliftonville, and it ends at Alabama State Route 86 at the Alabama–Mississippi state line. MS 388 was designated around 1957, from US 45 to a point west of the state line. The route was extended to Bigbee Valley and to the state line by 1974 and 1990, respectively.
Mississippi Highway 367 is a short state highway located in northeastern Mississippi. The route starts at MS 356 near Jacinto and travels northeastward. MS 367 intersects several county roads before ending at the Alcorn–Tishomingo county line. The route was designated around 1965, from a former routing of MS 356. The highway was paved by 1974, and the section in Tishomingo County was decommissioned by 1998.
Mississippi Highway 438 is a state highway in western Mississippi. The route starts at MS 1 in Wayside and travels eastward. The road travels through farmland and intersects U.S. Route 61 and its old alignment near Arcola. MS 438 continues eastward and ends at Sunflower River Road and Kinlock Road on the Washington–Sunflower county line near Kinlock. The route was constructed around 1950, connecting from MS 1 to US 61. The route was extended to the Washington–Sunflower county line by 1958, and to US 49W in Inverness by 1960. The section east of the county line was removed from the route by 1974.
Mississippi Highway 434 is a short state highway in western Mississippi. The route travels from U.S. Route 61 near Nitta Yuma and travels eastward. After crossing a creek, the road travels northeastward and enters Delta City, and the route ends inside the unincorporated community. The route was constructed around 1951, connecting from US 61 to Delta City. An extension along a county road to US 49W existed from 1957 to 1967.
Mississippi Highway 436 is a state highway in western Mississippi. The route starts at Eastside Lake Washington Road in Glen Allan and travels eastward. The road intersects MS 1 in Hampton and turns northeastward. It ends near Percy at U.S. Route 61. MS 436 was designated in 1957, along a road from US 61 to a point near the Washington–Sharkey county line. The route was extended westward to Glen Allan along a state-maintained road in 1958, and also eastward to Belzoni via a county road in 1967. The route east of US 61 was decommissioned by 1967.
Mississippi Highway 826 is a short state highway in western Mississippi. The route starts at U.S. Route 61 south of Rolling Fork. The road then travels northward through farmland, and MS 826 ends at its intersection with MS 14, west of the town. The road was constructed in 1955 to bypass Rolling Fork, and the route was designated around 1957, after a proposal by Sharkey County to transfer the road to state maintenance.
Mississippi Highway 510 is a state highway in eastern Mississippi. The route starts at MS 145 near Shubuta and travels eastward. The road turns southward near Matherville, and the route ends southeast of the unincorporated area. The road was constructed around 1957, and majority of the road was paved by 1967. A portion of the route east of Matherville was removed from the state highway system in 1999.
Mississippi Highway 462 is a state highway in western Mississippi. The route starts at U.S. Route 61 near Port Gibson, and it travels eastward. The road then turns northeastward, and the route ends at Willows Road and Old Port Gibson Road near Willows. MS 462 was designated around 1958, as a gravel road extending eastward from US 61 near Port Gibson. The road was extended to MS 461 from 1960 to 1963, then to the Natchez Trace Parkway from 1967 to 1998.
Mississippi Highway 556 is a state highway in southwestern Mississippi. The route starts at MS 184 in the town of Meadville and travels southeastwards. MS 556 crosses over the concurrency of U.S. Route 84 and US 98 inside the Homochitto National Forest, and the route ends at US 98 south of Bude. The route was designated around 1953, after a gravel road from US 84 to US 98, which had existed since 1928, was paved.
Mississippi Highway 403 is a state highway in central Mississippi. The route starts at U.S. Route 82 and MS 15 in Mathiston, and it travels north away from the town. It then turns east near Natchez Trace Parkway and then travels below it. MS 403 ends at the intersection of Clarkson Road and Old US 82 near a county highway maintenance barn. The route was designated by 1960, after a paved road extending from Mathiston was constructed around 1958. An extension northwards to MS 50 and MS 341 existed from 1960 to 1967.
US 45 Alt. near Prairie 
MS 25 near Aberdeen 
