Interstate 20 (I‑20) is a major east–west Interstate Highway in the Southern United States. I-20 runs 1,539 miles (2,477 km) beginning at an interchange with I-10 in Reeves County, Texas, and ending at an interchange with I-95 in Florence, South Carolina. Between Texas and South Carolina, I-20 runs through northern Louisiana, Mississippi, Alabama, and Georgia. The major cities that I-20 connects to include Dallas-Fort Worth, Texas; Shreveport, Louisiana; Jackson, Mississippi; Birmingham, Alabama; Atlanta, Georgia; and Columbia, South Carolina.
U.S. Route 425 (US 425) is a north–south United States highway that travels in the U.S. states of Mississippi, Louisiana, and Arkansas. It was first commissioned in 1989.
U.S. Route 45 is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,297 miles (2,087 km).
U.S. Route 82 is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern Arkansas, US 82 eventually became a 1,625-mile-long (2,615 km) route extending from the White Sands of New Mexico to Georgia's Atlantic coast.
U.S. Route 43 (US 43) is a 410-mile-long (660 km) north–south United States Highway in the Southern states of Alabama and Tennessee. It travels from Prichard, Alabama, to Columbia, Tennessee. The highway's southern terminus is in Prichard, at an intersection with US 90, and its northern terminus is in Columbia at an intersection with US 31/US 412/US 412 Bus.
Interstate 110 (I-110) is a 4.1-mile (6.6 km) freeway spur route in Biloxi, Mississippi, running south from I-10 to U.S. Route 90 (US 90). It is one of very few places on the Interstate Highway System utilizing a drawbridge. The southbound control city is Biloxi, with a series of bridges out over the Gulf of Mexico at the southern terminus. There is no northbound control city; the road is marked with trailblazers reading "TO I-10" instead. It ran entirely concurrently with Mississippi Highway 15 (MS 15), until MS 15 was truncated to I-10.
Mississippi Highway 69 is a state highway in eastern Mississippi. The route starts at the Alabama state line, and travels northwestward to Columbus. MS 69 then goes through downtown Columbus, and ends at U.S. Route 45 and US 82 in the west side of the town. Before the road was designated as MS 69 in 1941, it was a gravel road from Columbus to the state line. The road was paved in asphalt in 1953. In 1992, US 82 was realigned, and MS 69 was extended through Columbus to its current northern terminus.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Mississippi Highway 43 is a state highway in Mississippi that generally runs north–south in three segments: the first from US 90 near Bay St. Louis to MS 13 south of Columbia, resuming at MS 13 in southern Jefferson Davis County to end near Mendenhall, and finally starting again at MS 18 near Puckett to end at Attala Road 3122 in northern Attala County. It traverses approximately 235 miles (378 km), serving Hancock, Pearl River, Marion, Jefferson Davis, Lawrence, Simpson, Rankin, Madison, Leake, and Attala counties.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
Mississippi Highway 304 (MS 304) is an east-west state highway in the northwestern part of the U.S. state of Mississippi, running for 40.4 miles (65.0 km) as a four-lane freeway from U.S. Route 61 in Tunica Resorts to the Tennessee state line near Collierville. It is mostly concurrent with Interstate 69 (I-69) and Interstate 269 (I-269).
State Route 25 (SR 25) is a state highway in the eastern part of the U.S. state of Georgia. It travels south-to-north near the Atlantic Ocean, serving the Brunswick and Savannah metropolitan areas on its path from the Florida state line at the St. Marys River to the South Carolina state line at the Little Back River, a channel of the Savannah River. Except for the northern part of the highway, from Savannah to Port Wentworth, it is concurrent with U.S. Route 17 (US 17) for its entire length.
Mississippi Highway 13 is a state highway in Mississippi. It runs from north to south for 160.1 miles (257.7 km), serving the counties of Forrest, Pearl River, Lamar, Marion, Jefferson Davis, Simpson, Rankin, Smith, Scott, and Leake.
Mississippi Highway 18 is a state highway stretching across central Mississippi, from just a couple miles inland of the Mississippi River, through the state capital of Jackson, to the Alabama state line. It runs from east to west for 177.654 miles (285.906 km), serving 7 counties: Claiborne, Copiah, Hinds, Rankin, Smith, Jasper, and Clarke.
Mississippi Highway 468 runs from Mississippi Highway 475 in Flowood, Mississippi where it is known as Flowood Drive to MS 469 in Brandon, Mississippi. It is known as Pearson Road in Pearl, Mississippi.
Mississippi Highway 475 is a highway in central Mississippi. Its southern terminus is at MS 468. It then travels north to Jackson–Evers International Airport, and ends at MS 25 just north of it.
Mississippi Highway 149 is a state highway in Mississippi. The route designation is given to six former segments of U.S. Route 49, and two former sections of US 49W, within the state that have been bypassed. The sections run through Wiggins, Mount Olive, between Magee and Sanatorium, between Mendenhall and Braxton, in Richland, Mississippi, between Yazoo City and Silver City, Inverness, and Clarksdale. The total length of the eight sections of MS 149 is 58.073 miles (93.459 km).
Mississippi Highway 315 is an 80.4-mile-long (129.4 km) state highway located in northern Mississippi. The highway consists of two segments, one from MS 9W near Paris in Lafayette County to U.S. Route 278 (US 278) and MS 6 in Panola County, and another from US 278/MS 6 in Panola County to US 49/US 61 near Rich in Coahoma County. Along the way, the highway passes over Sardis Dam east of the town of Sardis. Though the two segments of MS 315 are signed north and south, they generally run in an east to westerly direction.
Mississippi Highway 603 is a 25.0-mile-long (40.2 km) state highway in Hancock County, Mississippi. The highway generally runs north–south from its southern terminus at U.S. Route 90 (US 90) in Waveland through Bay St. Louis and Kiln to its northern terminus at MS 53 near Necaise. The road is maintained by the Mississippi Department of Transportation (MDOT). MDOT and Mississippi's law code define MS 603's southern terminus as its intersection with MS 43 in Kiln. However, many maps such as Google Maps and MapQuest, and local signage show the highway continuing farther south to Waveland.' The road that became MS 603 has existed since 1927, and the highway was designated in 1950. The highway was also partially paved, from Waveland to Kiln, in 1950 and was completely paved in 1957. An interchange was created at Interstate 10 (I-10) in 1960.
Mississippi Highway 481 (MS 481) is a state highway in the west-central region of Mississippi running just under 35+1⁄2 miles (57.1 km) in length, signed as a north–south highway. The highway, designated in 1953, runs from MS 35 in rural Smith County inside the Bienville National Forest to MS 43 in West Leesburg, Rankin County.
US 80 in Brandon 
MS 43 in Goshen Springs 
