Allies
Leah Estrogen
Leah Estrogen (voiced by Brandy Norwood) is the secretary of the Mayor of Frank. She is romantic interest to Osmosis Jones who agreed with her on making changes to Frank's lifestyle choices.
Maria Amino
Maria Amino (voiced by Tasia Valenza) is a female Hispanic white blood cell cop who is highly skilled at fighting and the replacement for Leah. Despite showing her midriff, she's not drawn with a belly button. She also appears to have a crush on Drix.
Tom Colonic
Tom Colonic (voiced by Ron Howard) was the political opponent of Charles Phlegmming who wanted to be the next mayor of Frank so that the city will be healthy from a better diet. After Ozzy and Drix defeated Thrax and prevented his plan to kill Frank, resulting in Phlegmming's impeachment, he eventually won the bid for the mayor of Frank in a landslide.
Mayor Paul Spryman
Mayor Paul Spryman (voiced by Alanna Ubach) is the teenage mayor of the City of Hector. His being a teenage boy is a reflection of the fact that Hector is a teenage boy.
Ellen Patella
Ellen Patella (voiced by Vivica A. Fox) is the attorney at law and helps cells find homes in the City of Hector. She, like Leah and Maria respectively, also seems like someone Osmosis takes a romantic interest in.
Cilia Tyson
Cilia Tyson (voiced by Dawnn Lewis) is a cop in Christine who helped Ozzy stop the Pneumoniac and prove that Maximus is a traitor to the city. She was made the new police chief by the mayor.
Mayor Conscious Santorini
Mayor Conscious Santorini (voiced by Cree Summer) is the Mayor of Christine, and she is smarter and more responsible than Spryman. She even said that everyone in Christine are fans of Hector.
Drixeen
Drixeen (voiced by Miriam Flynn) is a friend to Cilia and she used to a cold pill. She looks a bit like Drix except she's green instead of red, has hair, and a right hand and left cannon, while Drix is red, has no hair, and his arm positions are the other way.
Dander
Dander (vocal effects provided by Frank Welker) is a dog germ formed from the saliva of Hector's dog Uno and Drix's pet.
Cells
Charles Phlegmming
Charles Phlegmming (voiced by William Shatner) is the former mayor of the City of Frank. Responsible for Frank's unhealthy eating habits, he wanted to be reelected for his own selfish benefits, but in the end, he lost to his political opponent, Tom Colonic. Whenever reporters enter his office, he would always deny all the various problems in Frank's body, trying to assure them that his body is in perfect shape. After Frank ingested the tainted hard-boiled egg that caused him to contract Thrax, Phlegmming went out of his way to ignore and downplay the issue as nothing more but a cold, but Ozzy tried to warn him it was a lot serious than that, let alone deadly, with Phlegmming threatening to put him in the next nosebleed if he ever spoke of it. He would also illegally control Frank's thoughts on a few occasions and made him take a cold pill against the wishes of his secretary, Leah, which is how Ozzy met, and joined forces with, Drix to stop Thrax's plan. After Ozzy and Drix uncovered Thrax's scheme after destroying a nightclub inside a zit on Frank's forehead, Phlegmming continued to ignore the warnings and fired Jones from the police force and ordered Drix to leave Frank's body by being peed out. Ozzy and Drix later reconciled and defied Phlegmming's orders to stop Thrax. After Leah tells him off for not caring about Frank's health and only caring about himself and his own selfish interests, including the election, Thrax infiltrates Frank's brain and steals a DNA chromosome from his hypothalamus gland, causing his body temperature to reach to a hazardous 108 degrees and sending him into a deadly coma. A trip to a chicken wing festival in Buffalo, New York, was Phlegmming's only shot of being reelected, but due to Thrax destroying the city and causing Frank's coma, it was quickly shot down when Frank was rushed to the hospital and all he could do was look on as the city burned to the ground. Ozzy later chases Thrax onto Frank's daughter, Shane's fake eyelash, where he recovers the DNA bead and traps Thrax on the eyelash, which falls into a vial of rubbing alcohol, dissolving Thrax to death, at which point he returns the stolen bead to its rightful place and Frank recovers from his fever, resulting in him getting his job back and making Drix his new partner. As for Phlegmming, Thrax's rampage resulted in a massive scandal that led up to his impeachment and removal from office, with Colonic winning the election in a landslide. Following his impeachment, Phlegmming was reduced to working as a custodian in Frank's bowels and while doing so, he accidentally presses a button that ejects himself from Frank's body via flatulence, causing his own implied demise.
Trudy
Trudy (voiced by Sherry Lynn) is the co-anchor of Nerve News Network.
Germs
Thrax
The main antagonist of Osmosis Jones , colloquially known as the Red Death. Thrax (voiced by Laurence Fishburne) is a vile and sadistic virus determined to kill Frank DeTorre within 48 hours, so that he can set a record for the virus to kill a man the fastest and be written about in medical books, annoyed that his previous killings had gone uncredited. Thrax kills his victims by causing their hypothalamus to cease body temperature regulation, creating fatal fevers. He has the ability to inflame organic material with his claws, causing cells to perish from overheating on contact. After arriving via Frank eating a hard boiled egg contaminated by chimpanzee saliva and mud, Thrax proceeds to discreetly travel through Frank, causing flu symptoms to mislead Frank's immune system. Though initially successful in inducing a fatal fever in Frank, Osmosis Jones is able to reverse the fever, and Thrax dies after getting stuck in a false eyelash that fell into a beaker of alcohol.
Scabies
Scabies [1] (voiced by David Ossman) is a bacterium and gang boss who lives in the left armpit of the city of Frank. Thrax arrives at the armpit shortly after entering the body and asks Scabies and his men, who are in a sauna, to join him. Scabies instead mocks him and orders Bruiser to beat him and bury him alive in a blackhead; Thrax breaks Bruiser's arm, and Scabies sends the rest of his men after him. Thrax uses his claws to fill the room with steam, and slices Scabies in half. Scabies melts from Thrax's touch, but he continues to mock Thrax as his melted remains are sucked down a drain.
Bruiser
Bruiser (voiced by Herschel Sparber) is a one-eyed germ with four arms.
He used to work for Scabies until the bacteria was killed by Thrax and eventually became convinced on Thrax's plans alongside the rest of the germs present. He was one of two germs killed by Thrax in the gas station explosion in the ingrown toenail once the latter lost his patience and most of their other allies were killed in the zit explosion.
Joe Cramp
Joe Cramp (voiced by Rodger Bumpass) is a germ with eyes hidden under a black blindfold and three legs.
He used to work for Scabies until the bacteria was killed by Thrax. He eventually became convinced on Thrax's plans. He was one of two germs killed by Thrax at their gas station hideout duro once the latter lost his patience and most of their other allies were killed in the zit explosion.
Scarlet Fever
Scarlet Fever (voiced by Tim Curry) is a dangerous bacterium who has been pursued for years by Ozzy throughout the City of Frank. With new germs moving in as a result of Frank's bad habits, Scarlet Fever intends to leave and find new territory. During a confrontation with Ozzy and Drix, the three are sucked up by a mosquito and placed in Hector when the mosquito drinks his blood. Realizing Hector's youth will rejuvenate him, Scarlet Fever consumes a water-like substance that transforms him into a more powerful form. He begins attacking the city, planning to kill Hector. Although he manages to fend off the local white blood cells, Ozzy and Drix fend him off and Scarlet Fever hijacks an attack helicopter, intending to go to the heart. Osmosis takes control of the helicopter and redirects it to the spleen. Scarlet Fever takes back control of the helicopter and forces Ozzy out, but he is unable to escape the spleen and torn apart. [2]
He is partially based on Thrax, with his abilities being very similar.
Nick O'Teen
Nick O'Teen (voiced by Tim Curry) serves as the main antagonist of the season one episode "Where There's Smoke". [3]
He is the nicotine of the cigarette that Hector smoked when he was offered it from some kids. Nick was defeated when Hector turned down another cigarette on his own.
Protozilla
Protozilla (voiced by Frank Welker) is an allergen with a weak form and a monster form with his monster form only usable in a body that is allergic to him.
Sal Monella
Sal Monella (voiced by Henry Winkler) is a gangster germ who enters the City of Hector on a Rusty Dog, which Hector did not know was tainted as the health inspector had the stand he got it from condemned upon his departure. Sal plans to dump illegal toxic waste in Hector's stomach. To make matters worse, Mayor Spryman was in his hostage. But his plans were destroyed when Ozzy and Drix made Hector barf by going on a ride at Rustyland called "The Barfy Bungee", and the mayor was rescued and brought back to the city.
Sylvian Fisher
Sylvian Fisher (voiced by Brian Posehn) is a nerdy brain cell who was trying to become mayor in the upcoming election. He planned to use a growth formula to make Hector grow uncontrollably and blame it on Spryman's carelessness. His name comes from the Sylvian fissure brain area and his transformed appearance resembles the Incredible Hulk, but with orange skin instead of green.
Stickety Lipid
Stickety Lipid (voiced by Rob Paulsen) is a sticky and bad cholesterol beatnik who kidnaps a bunch of fat cell kids in an attempt to clog Hector's artery.
Smirch
Smirch (voiced by Danny Bonaduce) is an acne germ that plans to make Hector get a zit. He also managed to trick Drix when he wanted to learn how to be "Street Wise". Actually, Drix helped him to get into a sebum oil refinery, so, he had an opportunity to grow gigantic and give Hector a zit, right on School Picture Day. Then Drix defeats him by dropping sodium bicarbonate toothpaste on him, shrinking him down to a tiny size, then Chief Gluteus put him in his shirt pocket.
General Malaise
General Malaise (voiced by Charlie Adler) is a bacterium who uses sugar to make his army of bacteria multiply.
Rhoda Virus
Rhoda Virus (voiced by Justine Bateman) is an intestinal virus who plans on giving Hector a bad case of gastroenteritis. Unfortunately, for her, Hector had a 12-bean salad, which gave him a gas attack, and the gas is deadly to her and her gang, so Rhoda disguises herself as a submarine captain to take Ozzy, Drix, and Maria into the intestines to destroy the Great White Bean. In the end, she and her henchmen are trapped in a gas bubble, killing them.
Cryo
Cryo (voiced by Susan Silo) is a virus that once tried to give Hector hypothermia during his ski trip, despite the fact that hypothermia is when the core temperatures of the body decrease to a critical level. Therefore, it is not a disease. She has the ability to fire freezing blasts from her elbows. She was eventually destroyed when struck by a nerve impulse from Hector's spine.
Chief Maximus
Chief Maximus (voiced by Rob Paulsen) is the Chief of Police in the city of Christine (a girl that Hector likes) that teams up with the Pneumoniac, due to his disillusion of being a male cell in a female body. After Pnuemoniac is defeated, Chief Maximus is removed from his position by Mayor Santorini
The Pneumoniac
The Pneumoniac (voiced by Pat Fraley) is a germ who is planning to give Christine pneumonia.
Mother Louse
Mother Louse is a head louse that laid her eggs on Hector's hair. She fell to her death when Drix got too close to one of Hector's hairs, but he caught Ozzy just in time and then he and Ozzy went into Hector's right ear.
Shane
Shane (voiced by Danny Cooksey) is a hormone leader of a testosterone gang that once tied up Mayor Spryman and took control over the Brain, turning common sense off and transforming Hector into a bad kid.
Billy Bob Bile
Billy Bob Bile (voiced by Frank Welker) is a stereotypical Hillbilly and owner of an appendix hotel who was causing detours which it resulted in Hector's appendix almost bursting. Only a quick trip to a hospital saved Hector's life and then the doctor there removed Billy's hotel. Billy attempted to return to civilization, only to cause Ozzy and Drix to slap cuffs on his wrists. When he tries to escape, he took a trip to the Small Intestine.
Mitosis Jones
Mitosis Jones (voiced by Phil LaMarr) is Ozzy's evil and mutated clone who understands that due to his mutation, the City of Hector will reject him. So he plans to take Ozzy's place on the iodine detail and steal it, and without the iodine, Hector cannot grow. At the end of the episode, Mitosis was rejected and lived in the body of Uno, Hector's pet dog, where he was happy.
PB
PB (voiced by Jeff Bennett) is the leader of the Lead Head gang. He was from a lead-painted shed that was painted in the 1960s, before 1974, when the government banned lead in paint. When Hector sniffed some paint dust, PB and his boys infect Hector. But thanks to Ozzy, Drix, and the Supplements, the Lead Heads were dropped into the bladder, and flushed out of Hector.
Professor Nightmare
Professor Nightmare (voiced by Pat Fraley) is a nightmare that originated from a movie Hector saw. Ozzy and Drix enter Hector's dreams and help him overcome his fear and crush him. He was the first villain to be based on a subconscious thought rather than being a germ or disease.
Humans
Frank DeTorri/e
Frank DeTorri (portrayed by Bill Murray in the film and voiced by Jeff Bennett in the TV series) is an unhealthy zookeeper widower from Rhode Island. Following the death of his wife, he began an unhealthy lifestyle, refused to exercise and even tried to push his habits onto his daughter. Once he ate a hard-boiled egg that was put into a chimp's mouth and fell on the ground, he contracted Thrax, which made him have a terrible fever that almost killed him. Once he recovered, his daughter, Shane made him have a healthy diet.
At the beginning of the cartoon series that is set in its own continuity, Frank is worse in shape than in the film as his cramps are persisting and is overweight. He is bitten by a mosquito that causes Ozzy, Drix, and Scarlet Fever to transferred to Hector's body. Frank later made a small cameo as one of the citizens in Rusty's Ridetropolis in "The Globfather".
He is the only human from the original life-action/animation-crossover movie to be seen in the animated television series.
Shane DeTorri
Shane (portrayed by Elena Franklin) is the daughter of Frank Detorri, who cared about her father's health and diet. During the films' climax, Ozzy is able to save her father's life after riding one of her tears into his mouth.
Bob DeTorri
Robert DeTorre (portrayed by Chris Elliott) is a zookeeper at Rhode Island and Frank DeTorre's brother. After Frank got fired from his position at the pea soup factory when news of him accidentally vomiting on Mrs. Boyd made the newspaper, Bob got him a job at the zoo.
While he lives a healthier and more responsible lifestyle than his brother Frank, he still possesses some of his careless traits as he encourages Frank to fight his infection with Beer and expressed desire to kick Shane out at the age of sixteen in the event he becomes her caretaker.
Mrs. Boyd
Mrs. Boyd (portrayed by Molly Shannon) is Shane's science and P.E. teacher who is a figure of humiliation, due to Frank accidentally throwing up on her after eating a polluted oyster at a school science fair two years earlier, which results in her filing a restraining order against him. Her two young sons Ralph and Chuck endure constant teasing from other children and her daughter Shirley, who is nicknamed Hurley, keeps transferring schools.
Shane was unaware of the restraining order as mentioned when Frank tried to get Mrs. Boyd to lift it. Following a zit explosion caused by Ozzy and Drix's fighting with Thrax's minions, Frank failed to get Mrs. Boyd to lift the restraining order and fled when she started shouting at him.
During the camping field trip, Shane had the bus stop when she saw her father being loaded into an ambulance and Mrs. Boyd tried to call her back. Bob shouted to Mrs. Boyd after telling Shane what happened that he is Shane's uncle.
Hector Cruz
Hector Cruz (voiced by Justin Cowden) is a Hispanic-American 13-year-old boy whose body is the current residence of Osmosis and Drix and whose body the show takes place in.
Travis Lum
Travis Lum (voiced by Rob Paulsen) is Hector's classmate and best friend who looks out for him. He sometimes likes to make mean jokes about Hector but also comes out as a true friend in the end.
Christine Kolchuck
Christine Kolchuck (voiced by Kimberly Brooks) is Hector's classmate and love interest. She tries to look after Hector's health and his attitude and also looks out for him.
Mrs. Cruz
Mrs. Cruz (voiced by Alanna Ubach) is Hector's mother.
Mr. Cruz
Mr. Cruz (voiced by Joe Lala) is Hector's father.
School Teacher
She is Hector's school teacher in the TV series Ozzy and Drix. She is unnamed and uncredited in all the episodes she appears in. It is implied she is French due to her speaking with the appropriate accent.
