- Easter Bunny (Christianity) – Anthropomorphic lagomorph.
- Easter Bilby (Australian) – Anthropomorphic bilby.
- Each Uisge (Scottish) – Malevolent water horse
- Eagle Spirit (Many cultures worldwide) – Leadership or guidance totem
- Ebu Gogo (Flores) – Diminutive humanoids, possibly inspired by Homo floresiensis
- Echidna (Greek)
- Echeneis (Medieval Bestiaries) – Remora, said to attach to ships to slow them down
- Edimmu (Sumerian) – Ghosts of those not buried properly
- Egbere (Yoruba) – Humanoid that carries a magical mat
- Eikthyrnir (Norse) – The stag of Valhalla
- Einherjar (Norse) – Spirits of brave warriors
- Ekek (Philippine) – Flesh-eating, winged humanoids
- Elbow Witch (Ojibwa) – Hags with awls in their elbows
- Eldjötnar (Norse) – Fire Giants who reside in Muspelheim, with Surtr as their leader
- Elemental (Alchemy) – Personification of one of the Classical elements
- ‘Elepaio (Hawaiian) – Monarch flycatcher spirit that guides canoe-builders to the proper trees
- Elf (Germanic) – Nature and fertility spirit
- Eloko (Central Africa) – Little people and malevolent nature spirits
- El Silbon
- Elwetritsch (German) – Birdlike forest creature of the Palatinate and Pennsylvania Dutch country
- Emere (Yoruba) – Child that can move back and forth between the material world and the afterlife at will
- Emim (Jewish) – Giant
- Empusa (Greek) – Female demon that waylays travelers and seduces and kills men
- Encantado (Brazilian) – Dolphin-human shapeshifter
- Enchanted Moor (Portuguese) – Enchanted princesses
- Enenra (Japanese) – Smoke spirit
- Enfield (Heraldic) – Fox-greyhound-lion-wolf-eagle hybrid
- Engkanto (Philippine) – Neutral nature spirit
- Enkō (Japanese) – Kappa of Shikoku and western Honshū
- Epimeliad (Greek) – Apple tree nymph
- Erchitu (Sardinia) – Ox-human, wereox
- Er Gui (Chinese) – Hungry ghost
- Erinyes (Greek) – Winged spirits of vengeance or justice, also known as Furies
- Erlking (German) – Death spirit
- Erymanthian Boar (Greek) – Giant boar
- Ethiopian Pegasus (Medieval Bestiaries) – Horned, winged horse
- Etiäinen (Finnish) – Spirit being of a living person
- Ettin (English) – Three-headed giant
- Eurynomos (Greek) – Blue-black, carrion-eater in the underworld
- Ewah (Cherokee) – Human-cougar hybrid
- Ežerinis (Lithuanian) – Lake spirit