| No. | Portrait | Governor | From | Until | Secretary of the Indies  [1] | Valido Secretary of the Universal Bureau
 First Secretary of State
 | Monarch | 
|---|
| 1 |   | Antonio de Mendoza | 14 November 1535 | 25 November 1550 | Vacant (Overseas Affairs hold by the President of the Council of the Indies) | No valido |   Charles I
 | 
| 2 |   | Luís de Velasco | 25 November 1550 | 31 July 1564 | 
|   Philip II
 | 
| Int. |   | Francisco Ceinos , Dean of the  Audiencia
 | 1 August 1564 | 19 October 1566 | 
| 3 |   | Gastón Carrillo de Peralta y Bosquete, 3rd Marquess of Falces
 | 19 October 1566 | 11 November 1567 | 
| Acting |   | Alonso de Muñoz , Royal commissioner of New Spain
 | 11 November 1567 | 15 April 1568 | 
| Luis Carrillo, Royal commissioner of New Spain
 | 
| Francisco Ceinos, Dean of the  Audiencia
 | 15 April 1568 | 5 November 1568 | 
| 4 |   | Martín Enríquez de Almanza | 5 November 1568 | 4 October 1580 | 
| 5 |   | Lorenzo Suárez de Mendoza, 4th Count of La Coruña
 | 4 October 1580 | 19 June 1583 | 
| Int. |   | Luis de Villanueva y Zapata , Dean of the  Audiencia
 | 19 June 1583 | 25 September 1584 | 
| 6 |   | Pedro de Moya y Contrerás (Archbishop of Mexico)
 | 25 September 1584 | 17 October 1585 | 
| 7 |   | Álvaro Manrique de Zúñiga 1st Marquess of Villamanrique
 | 17 October 1585 | 27 January 1590 | 
| 8 |   | Luís de Velasco Marquess of Salinas
 | 27 January 1590 | 5 November 1595 | 
| 9 |   | Gaspar de Zúñiga Acevedo y Fonseca, 5th Count of Monterrey
 | 5 November 1595 | 27 October 1603 | 
|    Duke of Lerma  [2]  |   Philip III
 | 
| 10 |   | Juan de Mendoza y Luna, Marquess of Montesclaros
 | 27 October 1603 | 2 July 1607 | 
| 11 |   | Luís de Velasco, Marquess of Salinas
 | 2 July 1607 | 19 June 1611 | 
| 12 |   | García Guerra ,  O.P. (Archbishop of Mexico)
 | 19 June 1611 | 22 February 1612 | 
| Int. |   | Pedro Otárola, Dean of the  Audiencia
 | 22 February 1612 | 18 October 1612 | 
| 13 |   | Diego Fernández de Córdoba, Marquess of Guadalcázar and Count of Posadas
 | 18 October 1612 | 14 March 1621 | 
|    Cristóbal Gómez de Sandoval  [2]  | 
| Acting |   | Paz de Valecillo, Dean of the  Audiencia
 | 14 March 1621 | 11 September 1621 | 
|    Philip IV  | 
|    Baltasar de Zúñiga  [2]  | 
| 14 |   | Diego Carrillo de Mendoza y Pimentel, 1st Marquess of Gélves
 | 21 September 1621 | 1 November 1624 | 
|    Count-Duke of Olivares  [2]  | 
| Vacant Due to the discrepancy on the arrival of successor Viceroy
 from 1 to 3 November 1624.
 | 
| 15 |   | Rodrigo Pacheco y Osorio de Toledo, 3rd Marquess of Cerralvo
 | 3 November 1624 | 16 September 1635 | 
| 16 |   | Lope Díez de Aux de Armendáriz, Marquess of Cadreita
 | 16 September 1635 | 28 August 1640 | 
| 17 |   | Diego Roque López Pacheco Cabrera y Bobadilla, 7th Duke of Escalona, 7th Marquess of Villena and 7th Count of Xiquena
 | 28 August 1640 | 10 June 1642 | 
| 18 |   | Juan de Palafox y Mendoza (Bishop of Puebla)
 | 10 June 1642 | 23 November 1642 | 
| 19 |   | García Sarmiento de Sotomayor, 2nd Count of Salvatierra and Marquess of Sobroso
 | 23 November 1642 | 14 May 1648 | 
|    Luis de Haro  [2]  | 
| 20 |   | Marcos de Torres y Rueda (Bishop of Yucatan)
 | 15 May 1648 | 22 April 1649 | 
| Int. |   | Matías de Peralta, Dean of the  Audiencia
 | 22 April 1649 | 28 June 1650 | 
| 21 |   | Luis Enríquez de Guzmán, 9th Count of Alba de Liste and Marquess of Villaflor
 | 28 June 1650 | 15 August 1653 | 
| 22 |   | Francisco Fernández de la Cueva, 8th Duke of Alburquerque, Marquess of Cuéllar, Count of Ledesma and of Huelma
 | 15 August 1653 | 16 September 1660 | 
| 23 |   | Juan de Leyva de la Cerda, Marquess of Adrada
 | 16 September 1660 | 29 June 1664 | 
| No valido [3] | 
| 24 |   | Diego Osorio de Escobar y Llamas (Bishop of Puebla)
 | 29 June 1664 | 15 October 1664 | 
| 25 |   | Antonio Sebastián de Toledo Molina y Salazar, 2nd Marquess of Mancera
 | 16 October 1664 | 20 November 1673 | 
|    Juan Everardo Nithard  [2]  |   Charles II
 | 
|    Fernando de Valenzuela  [2]  | 
| 26 |   | Pedro Nuño Colón de Portugal y Castro, 6th Duke of Veragua, 6th Marquess of Jamaica and 6th Count of Gelves
 | 20 November 1673 | 13 December 1673 | 
| 27 |   | Payo Enríquez de Rivera Manrique ,  O.S.A. (Bishop of Guatemala and Archbishop of Mexico)
 | 13 December 1673 | 7 November 1680 | 
|    John Joseph of Austria  [4]  | 
|    Duke of Medinaceli  [4]  | 
| 28 |   | Tomás Antonio Manuel Lorenzo de la Cerda y Aragón 3rd Marquess of La Laguna de Camero Viejo
 | 7 November 1680 | 16 June 1686 | 
| Count of Oropesa  [4] | 
| 29 |   | Melchor Portocarrero y Lasso de la Vega, 3rd Count of Monclova
 | 16 June 1686 | 20 November 1688 | 
| 30 |   | Gaspar Melchor Baltasar de la Cerda Silva Sandoval y Mendoza, 8th Count of Galve, Lord of Salcedón and Tortola
 | 20 November 1688 | 27 February 1696 | 
|    Cardinal Portocarrero  [2]  | 
| 31 |   | Juan de Ortega Cano Montañez y Patiño (Bishop of Durango, Guatemala, Michoacán and Archbishop of Mexico)
 | 27 February 1696 | 18 December 1696 | 
| 32 |   | José Sarmiento Valladares Arines de Romay, 1st Duke of Atrisco, Count of Moctezuma and of Tula
 | 18 December 1696 | 4 November 1701 | 
| Count of Oropesa  [4] | 
|    Cardinal Portocarrero  [2]  | 
| Antonio de Ubilla [5] |   Philip V
 | 
| 33 |   | Juan de Ortega Cano Montañez y Patiño (Archbishop of Mexico)
 | 4 November 1701 | 27 November 1702 | 
| 34 |   | Francisco V Fernández de la Cueva Enríquez y Fernández de la Cueva, 10th Duke of Alburquerque and Marquess of Cuéllar
 | 27 November 1702 | 13 November 1710 | 
| Marquis of Mejorada del Campo  [5] | 
| 35 |   | Fernando de Alencastre Noroña y Silva, 1st Duke of Linares and Marquess of Valdefuentes
 | 13 November 1710 | 16 July 1716 | 
| Manuel de Vadillo y Velasco [5] | 
|    José de Grimaldo  [5]  | 
| Bernardo Tinajero de la Escalera [6] | 
| No secretary | 
| 36 |   | Baltasar de Zúñiga Guzmán Sotomayor y Mendoza, 1st Duke of Arión and Marquess of Valero
 | 16 July 1716 | 15 October 1722 | 
|   Miguel Fernández Durán [6]
 | 
| Andres Matías de Pes Marzaraga [6] | 
| 37 |   | Juan de Acuña y Bejarano, 2nd Marquess of Casa Fuerte
 | 15 October 1722 | 17 March 1734 | 
| No secretary | 
| Antonio de Sopeña y Mioño [6] | 
| Juan Bautista de Orendáin  [5] |  | 
|   Louis I
 From 1700 to 1724, Philip V was the king; then from 1724 to 1746. Louis I only reigned in 1724.
 | 
|    José de Grimaldo  [5]  |   Philip V
 | 
|    Baron Ripperda  [5]  | 
|    José de Grimaldo  [5]  | 
|  José de Patiño y Rosales  [6] | 
| Juan Bautista de Orendáin  [5] | 
| 38 |   | Juan Antonio de Vizarrón y Eguiarreta (Archbishop of Mexico)
 | 17 March 1734 | 17 August 1740 | 
|    José de Patiño y Rosales  [7]  | 
| Mateo Pablo Díaz de Lavandero [6] |    Marquess of Villarías  [7]  | 
|  Marquess of Villarías  [6] | 
| 39 |   | Pedro de Castro Figueroa y Salazar, 1st Duke of La Conquista and 1st Marquess of Gracia Real
 | 17 August 1740 | 22 August 1741 | 
| Int. |   | Pedro Malo de Villavicencio , President of the  Audiencia
 | 23 August 1741 | 2 November 1742 | 
| 40 |   | Pedro Cebrián y Agustín, 5th Count of Fuenclara
 | 3 November 1742 | 9 July 1746 | 
|  Marquess of Ensenada  [6] | 
| 41 |   | Juan Francisco de Güemes y Horcasitas, 1st Count of Revillagigedo
 | 9 July 1746 | 9 November 1755 |   Ferdinand VI
 | 
|    José de Carvajal  [7]  | 
|    Duke of Huéscar (Interim) [7]  | 
|    Ricardo Wall  [7]  | 
|  Ricardo Wall (Interim) [8] | 
| Julián de Arriaga y Ribera [8] | 
| 42 |   | Agustín de Ahumada y Villalón, Marquess of Amarillas
 | 10 November 1755 | 5 February 1760 | 
|   Charles III
 | 
| Int. |   | Francisco Antonio de Echávarri , Dean of the  Audiencia
 | 5 February 1760 | 28 April 1760 | 
| 43 |   | Francisco Cajigal de la Vega | 28 April 1760 | 5 October 1760 | 
| 44 |   | Joaquín de Montserrat, Marquess of Cruillas
 | 5 October 1760 | 24 August 1766 | 
|    Jerónimo Grimaldi  [7]  | 
| 45 |   | Carlos Francisco de Croix, Marquess of Croix
 | 24 August 1766 | 22 September 1771 | 
| 46 |   | Antonio María de Bucareli y Ursúa | 22 September 1771 | 9 April 1779 | 
|  Marquess of Sonora  [8] | 
|    Count of Floridablanca  [7]  | 
| Int. |   | Francisco Romá y Rosell , Regent of the  Audiencia
 | 10 April 1779 | 22 August 1779 | 
| 47 |   | Martín de Mayorga Ferrer , Captain General of Guatemala
 | 23 August 1779 | 28 April 1783 | 
| 48 |   | Matías de Gálvez y Gallardo , Captain General of Guatemala
 | 28 April 1783 | 20 October 1784 | 
| – |   | Vicente de Herrera y Rivero, Regent of the  Audiencia
 | 20 October 1784 | 17 June 1785 | 
| 49 |   | Bernardo de Gálvez y Madrid, 1st Viscount of Galveston and 1st Count of Gálvez
 | 17 June 1785 | 30 November 1786 | 
| Int. |   | Eusebio Sánchez Pareja y Beleño Regent of the  Audiencia
 | 30 November 1786 | 8 May 1787 | 
| 50 |   | Alonso Núñez de Haro y Peralta (Archbishop of Mexico)
 | 8 May 1787 | 16 August 1787 | 
|  Count of Floridablanca (Interim) [8] | 
|  Antonio Porlier [9] 
   Antonio Valdés y Fernández Bazán  [10] | 
| 51 |   | Manuel Antonio Flórez Maldonado | 16 August 1787 | 16 October 1789 | 
| 52 |   | Juan Vicente de Güemes Pacheco de Padilla y Horcasitas, 2nd Count of Revillagigedo
 | 17 October 1789 | 11 July 1794 | 
|   Charles IV
 | 
| No secretary (affairs of Indies distributed among different secretariats) |    Count of Aranda (Interim) [7]  | 
|    Manuel Godoy  [7]  | 
| 53 |   | Miguel de la Grúa Talamanca de Carini y Branciforte, 1st Marquess of Branciforte
 | 12 July 1794 | 31 May 1798 | 
|    Francisco de Saavedra  [7]  | 
| 54 |   | Miguel José de Azanza Alegría, 1st Duke of Santa Fe
 | 31 May 1798 | 30 April 1800 | 
|    Mariano Luis de Urquijo  [7]  | 
| 55 |   | Félix Berenguer de Marquina | 30 April 1800 | 4 January 1803 | 
|    Pedro Cevallos Guerra  [7]  | 
| 56 |   | José de Iturrigaray  [11] | 4 January 1803 | 16 September 1808 | 
|    Gonzalo O'Farril  [7]  | 
|    Pedro Cevallos Guerra  [7]  |  Ferdinand VII | 
|  Miguel José de Azanza  [12] |    Mariano Luis de Urquijo  [7]  |   Joseph I  [13]
 | 
| 57 |   | Pedro de Garibay  [11] | 16 September 1808 | 19 July 1809 | 
| 58 |   | Francisco Javier de Lizana y Beaumont (Archbishop of Mexico) [11]
 | 19 July 1809 | 8 May 1810 | 
| 59 |   | Pedro Catani [11] | 8 May 1810 | 14 September 1810 | 
| 60 |   | Francisco Javier Venegas, 1st Marquess of Reunión and of New Spain  [11]
 | 14 September 1810 | 4 March 1813 | 
| 61 |   | Félix María Calleja del Rey, 1st Count of Calderón  [11]
 | 4 March 1813 | 20 September 1816 | 
| No secretary |    Juan O'Donoju (Interim) [7]  | 
| Fernando de Laserna (Interim) [7] | 
| Manuel Antonio de la Bodega y Mollinedo [14] | José Luyando (Interim) [7] |    Ferdinand VII  | 
|  Miguel de Lardizabal [14] |    José Miguel de Carvajal-Vargas  [7]  | 
|    Pedro Cevallos Guerra  [7]  | 
| No secretary | Jaun Estebán Lozano de Torres [7] | 
|    Pedro Cevallos Guerra  [7]  | 
| 62 |   | Juan Ruiz de Apodaca, 1st Count of Venadito
 | 20 September 1816 | 5 July 1821 | 
|    José García de León  [7]  | 
|    Carlos Martínez de Irujo (Interim) [7]  | 
|    Manuel González Salmón (Interim) [7]  | 
|    Joaquín José Melgarejo  [7]  | 
| Antonio González Salmón (Interim) [14] | 
| Juan Jabat Aztal [7] | 
|  Antonio Porcel Román [14] | 
|    Evaristo Pérez de Castro  [7]  | 
| Ramón Gil de la Cuadra [14] | 
| Antonio de Guilleman(Interim) [14] | Joaquín Anduaga Cuenca(Interim) [7] | 
| Francisco de Paula Escudero (Interim) [7] | 
| Ramón Olaguer Feliú [14] | 
|    Eusebio Bardají y Azara  [7]  | 
| Ramón López Pelegrín [14] | 
| 63 |   | Francisco Novella Azabal Pérez y Sicardo | 15 July 1821 | 21 July 1821 | 
| 64 |   | Juan O'Donojú | 21 July 1821 | 28 September 1821 |