![]() | |
Clinical data | |
---|---|
Other names | N,N-dimethyl-8-chloro-5-methoxy-1-aminotetralin |
ATC code |
|
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C13H18ClNO |
Molar mass | 239.74 g·mol−1 |
3D model (JSmol) | |
| |
|
Lometraline (INN; developmental code name CP-14,368) is a drug and an aminotetralin derivative. [1] A structural modification of tricyclic neuroleptics, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent. [2] [3] However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, though clinical studies revealed no psychoactivity at the doses used and further investigation was suspended. [1] [4] [5] Further experimental modifications of the chemical structure of lometraline resulted in the discovery of tametraline, a potent inhibitor of the reuptake of dopamine and norepinephrine, which in turn led to the discovery of the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI). [6]