MAP1S

MAP1S
Identifiers
Aliases	MAP1S , BPY2IP1, C19orf5, MAP8, VCY2IP-1, VCY2IP1, microtubule associated protein 1S
External IDs	OMIM: 607573; MGI: 2443304; HomoloGene: 10047; GeneCards: MAP1S; OMA:MAP1S - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 17,719,242 bp [1] End 17,734,513 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.3 Start 71,358,576 bp [2] End 71,370,173 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis prefrontal cortex right frontal lobe Brodmann area 9 anterior cingulate cortex stromal cell of endometrium muscle of thigh putamen gonad Top expressed in yolk sac Rostral migratory stream neural layer of retina superior frontal gyrus internal carotid artery ankle joint dentate gyrus of hippocampal formation granule cell primary visual cortex perirhinal cortex entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding deoxyribonuclease activity microtubule binding tubulin binding actin filament binding protein binding beta-tubulin binding identical protein binding actin binding Cellular component cytosol cell projection microtubule cytoskeleton spindle synapse cell junction soma dendrite nucleolus perinuclear region of cytoplasm microtubule cytoskeleton nucleus cytoplasm microtubule associated complex Biological process neuron projection morphogenesis nervous system development autophagy brain development microtubule bundle formation mitochondrion transport along microtubule microtubule cytoskeleton organization apoptotic process DNA metabolic process axonogenesis dendrite development regulation of microtubule depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55201 270058 Ensembl ENSG00000130479 ENSMUSG00000019261 UniProt Q66K74 Q8C052 RefSeq (mRNA) NM_001308363 NM_018174 NM_173013 RefSeq (protein) NP_001295292 NP_060644 NP_766601 Location (UCSC) Chr 19: 17.72 – 17.73 Mb Chr 8: 71.36 – 71.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene. ^{[5] [6] [7] [8] [9]}

Interactions

MAP1S has been shown to interact with RASSF1. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000130479 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019261 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu L, McKeehan WL (Feb 2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC   3241999 . PMID   11827465.
6. Orbán-Németh Z, Simader H, Badurek S, Tranciková A, Propst F (Jan 2005). "Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family". J. Biol. Chem. 280 (3): 2257–65. doi: 10.1074/jbc.M408984200 . PMID   15528209.
7. Ding J, Valle A, Allen E, Wang W, Nardine T, Zhang Y, Peng L, Yang Y (January 2006). "Microtubule-associated protein 8 contains two microtubule binding sites". Biochem. Biophys. Res. Commun. 339 (1): 172–9. doi:10.1016/j.bbrc.2005.10.199. PMID   16297881.
8. Wong EY, Tse JY, Yao KM, Lui VC, Tam PC, Yeung WS (Feb 2004). "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein". Biol. Reprod. 70 (3): 775–84. doi: 10.1095/biolreprod.103.018531 . PMID   14627543.
9. "Entrez Gene: MAP1S microtubule-associated protein 1S".
10. Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi: 10.1158/0008-5472.CAN-04-3896 . PMID   15753381.
11. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi: 10.1158/0008-5472.CAN-04-0267 . PMID   15205320.

Further reading

• Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC   3225227 . PMID   12762840.
• Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi: 10.1158/0008-5472.CAN-04-0267 . PMID   15205320.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Liu L, Vo A, McKeehan WL (2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi: 10.1158/0008-5472.CAN-04-3896 . PMID   15753381.
• Liu L, Vo A, Liu G, McKeehan WL (2005). "Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein". Biochem. Biophys. Res. Commun. 332 (3): 670–6. doi:10.1016/j.bbrc.2005.05.006. PMC   3225229 . PMID   15907802.
• Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID   16396496.