MED16

MED16
Identifiers
Aliases	MED16 , DRIP92, THRAP5, TRAP95, mediator complex subunit 16
External IDs	OMIM: 604062; MGI: 2158394; HomoloGene: 64602; GeneCards: MED16; OMA:MED16 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 867,630 bp [1] End 893,218 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 79,730,542 bp [2] End 79,744,757 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right uterine tube right lobe of liver gastric mucosa canal of the cervix apex of heart gonad granulocyte anterior pituitary muscle of thigh Top expressed in seminiferous tubule internal carotid artery external carotid artery spermatocyte Rostral migratory stream epithelium of stomach dentate gyrus of hippocampal formation granule cell tibiofemoral joint molar extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vitamin D receptor binding transcription coregulator activity thyroid hormone receptor binding catalytic activity transcription coactivator activity protein binding signaling receptor activity Cellular component nucleoplasm nucleus mediator complex membrane Biological process transcription, DNA-templated regulation of transcription by RNA polymerase II androgen receptor signaling pathway intracellular steroid hormone receptor signaling pathway positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter positive regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10025 216154 Ensembl ENSG00000282092 ENSG00000175221 ENSMUSG00000013833 UniProt Q9Y2X0 Q6PGF3 RefSeq (mRNA) NM_005481 NM_001163276 NM_198107 NM_001359629 RefSeq (protein) NP_005472 XP_006513550.1 XP_006513551.1 Location (UCSC) Chr 19: 0.87 – 0.89 Mb Chr 10: 79.73 – 79.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene. ^{[5] [6] [7]}

Interactions

MED16 has been shown to interact with Thyroid hormone receptor alpha, ^[6] Estrogen receptor alpha ^[8] and Cyclin-dependent kinase 8. ^{[6] [8]}

References

1. ENSG00000175221 GRCh38: Ensembl release 89: ENSG00000282092, ENSG00000175221 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013833 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
6. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi: 10.1016/S1097-2765(00)80463-3 . PMID   10198638.
7. "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5".
8. Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5). United States: 2642–7. Bibcode:2002PNAS...99.2642K. doi: 10.1073/pnas.261715899 . ISSN   0027-8424. PMC   122401 . PMID   11867769.

Further reading

• Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi: 10.1073/pnas.93.16.8329 . PMC   38670 . PMID   8710870.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC   311086 . PMID   11337467.
• Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi: 10.1074/jbc.M206061200 . PMID   12218053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi: 10.1074/jbc.C300444200 . PMID   14576168.
• Wallberg AE, Yamamura S, Malik S, et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi: 10.1016/S1097-2765(03)00391-5 . PMID   14636573.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi: 10.1074/jbc.M312523200 . PMID   14638676.
• Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi: 10.1016/j.molcel.2004.05.006 . PMID   15175163.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• MED16 human gene location in the UCSC Genome Browser .
• MED16 human gene details in the UCSC Genome Browser .