MED22

MED22
Identifiers
Aliases	MED22 , MED24, SURF5, surf-5, mediator complex subunit 22, SRB6
External IDs	OMIM: 185641 MGI: 98446 HomoloGene: 4913 GeneCards: MED22
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,348,131 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,800,689 bp
RNA expression pattern
	Top expressed in
	blood; ; sural nerve; ; right coronary artery; ; gastric mucosa; ; prefrontal cortex; ; left uterine tube; ; stromal cell of endometrium; ; canal of the cervix; ; myometrium; ; monocyte;
	Top expressed in
	spermatocyte; ; ganglionic eminence; ; medial ganglionic eminence; ; secondary oocyte; ; lip; ; lacrimal gland; ; yolk sac; ; maxillary prominence; ; ankle joint; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coregulator activity ; protein binding ;
Cellular component	cytoplasm ; mediator complex ; nucleus ;
Biological process	regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	6837
	20933
	ENSG00000281022 ; ENSG00000148297
	ENSMUSG00000015776
	Q15528 ; Q5T8T8
	Q62276
	NM_181491 ; NM_006752 ; NM_133640
	NM_001033908 ; NM_011513 ; NM_001378786 ; NM_001378787 ; NM_001378788 Contents Function ; Interactions ; References ; Further reading ;
	NP_598395 ; NP_852468
	NP_001029080 ; NP_035643 ; NP_001365715 ; NP_001365716 ; NP_001365717
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.^[5]^[6]^[7]

Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.^[7]

Interactions

MED22 has been shown to interact with MED30.^[8]

Related Research Articles

Mediator of RNA polymerase II transcription, subunit 12 homolog , also known as MED12, is a human gene found on the X chromosome.

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.

Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.

Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene. It forms part of the Mediator complex.

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.

Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

References

1 2 3 ENSG00000148297 GRCh38: Ensembl release 89: ENSG00000281022, ENSG00000148297 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015776 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yon J, Jones T, Garson K, Sheer D, Fried M (Mar 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Human Molecular Genetics. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
↑ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi: 10.1016/j.molcel.2004.05.006 . PMID 15175163.
1 2 "Entrez Gene: SURF5 surfeit 5".
↑ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID 12584197.

De Falco S, Russo G, Angiolillo A, Pietropaolo C (Apr 1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene. 126 (2): 227–35. doi:10.1016/0378-1119(93)90371-9. PMID 8482538.
Garson K, Duhig T, Armes N, Colombo P, Fried M (Nov 1995). "Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene". Genomics. 30 (2): 163–70. doi:10.1006/geno.1995.9889. PMID 8586415.
Garson K, Duhig T, Fried M (1997). "Tissue-specific processing of the Surf-5 and Surf-4 mRNAs". Gene Expression. 6 (4): 209–18. PMC 6148271 . PMID 9196076.
Duhig T, Ruhrberg C, Mor O, Fried M (Aug 1998). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673.
Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C (Feb 2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID 12584197.
Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi: 10.1074/jbc.C300444200 . PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi: 10.1074/jbc.M312523200 . PMID 14638676.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752 . PMID 14759258.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000148297 GRCh38: Ensembl release 89: ENSG00000281022, ENSG00000148297 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015776 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8499913-5] Yon J, Jones T, Garson K, Sheer D, Fried M (Mar 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Human Molecular Genetics. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.

[pmid15175163-6] Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi: 10.1016/j.molcel.2004.05.006 . PMID 15175163.

[entrez-7] 1 2 "Entrez Gene: SURF5 surfeit 5".

[pmid12584197-8] Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID 12584197.

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MED22

Contents

Function

Interactions

Related Research Articles

References

Further reading