MED30

MED30
Identifiers
Aliases	MED30 , MED30S, THRAP6, TRAP25, mediator complex subunit 30
External IDs	OMIM: 610237; MGI: 1917040; HomoloGene: 12329; GeneCards: MED30; OMA:MED30 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.11 Start 117,520,713 bp [1] End 117,540,262 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 C Start 52,575,804 bp [2] End 52,593,960 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte bone marrow monocyte ganglionic eminence sperm testicle cartilage tissue Achilles tendon left ovary Top expressed in medial ganglionic eminence zygote interventricular septum endocardial cushion secondary oocyte primary oocyte granulocyte atrioventricular valve thymus lens More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity vitamin D receptor binding thyroid hormone receptor binding nuclear receptor coactivator activity ubiquitin protein ligase activity protein binding signaling receptor activity Cellular component nucleoplasm nucleus mediator complex ubiquitin ligase complex Biological process transcription, DNA-templated androgen receptor signaling pathway stem cell population maintenance intracellular steroid hormone receptor signaling pathway positive regulation of transcription, DNA-templated protein ubiquitination regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90390 69790 Ensembl ENSG00000164758 ENSMUSG00000038622 UniProt Q96HR3 Q9CQI9 RefSeq (mRNA) NM_001282986 NM_080651 NM_001363182 NM_027212 RefSeq (protein) NP_001269915 NP_542382 NP_001350111 NP_081488 Location (UCSC) Chr 8: 117.52 – 117.54 Mb Chr 15: 52.58 – 52.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Med30
Identifiers
Symbol	Med30
Pfam	PF11315
InterPro	IPR021019
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. ^[5] It represents subunit Med30 of the Mediator complex and is metazoan-specific, ^[6] having no homologues in yeasts.

Interactions

MED30 has been shown to interact with MED22. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164758 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038622 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6".
6. Baek HJ, Malik S, Qin J, Roeder RG (April 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC   133729 . PMID   11909976.
7. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID   12584197.

Further reading

• Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, et al. (June 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi: 10.1016/j.molcel.2004.05.006 . PMID   15175163.
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, et al. (February 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi: 10.1074/jbc.M312523200 . PMID   14638676.
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, et al. (December 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi: 10.1074/jbc.C300444200 . PMID   14576168.
• Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID   12584197.
• Wang Q, Sharma D, Ren Y, Fondell JD (November 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". The Journal of Biological Chemistry. 277 (45): 42852–8. doi: 10.1074/jbc.M206061200 . PMID   12218053.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, et al. (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC   135748 . PMID   12136098.
• Baek HJ, Malik S, Qin J, Roeder RG (April 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC   133729 . PMID   11909976.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (April 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID   10235267. S2CID   23646963.
• Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, et al. (April 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
• Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, et al. (March 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi: 10.1016/S1097-2765(00)80463-3 . PMID   10198638.

This article incorporates text from the public domain Pfam and InterPro: IPR021019