MED31

MED31
Identifiers
Aliases	MED31 , 3110004H13Rik, Soh1, CGI-125, mediator complex subunit 31
External IDs	MGI: 1914529 HomoloGene: 9368 GeneCards: MED31
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 6,643,311 bp [1] End 6,651,634 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B4 Start 72,102,550 bp [2] End 72,106,418 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell anterior pituitary sperm islet of Langerhans prefrontal cortex right adrenal gland nucleus accumbens right uterine tube left adrenal gland caudate nucleus Top expressed in endocardial cushion medial ganglionic eminence facial motor nucleus interventricular septum secondary oocyte atrioventricular valve olfactory epithelium morula right lung lobe seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component core mediator complex nucleus nucleoplasm ubiquitin ligase complex mediator complex Biological process regulation of transcription by RNA polymerase II limb development transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of fibroblast proliferation protein ubiquitination transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51003 67279 Ensembl ENSG00000108590 ENSMUSG00000020801 UniProt Q9Y3C7 Q9CXU1 RefSeq (mRNA) NM_016060 NM_026068 RefSeq (protein) NP_057144 NP_080344 Location (UCSC) Chr 17: 6.64 – 6.65 Mb Chr 11: 72.1 – 72.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Med31
Identifiers
Symbol	Med31
Pfam	PF05669
InterPro	IPR008831
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. ^{[5] [6]} It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant ^[7] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000108590 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020801 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
6. "Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)".
7. Fan HY, Klein HL (August 1994). "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae". Genetics. 137 (4): 945–56. doi:10.1093/genetics/137.4.945. PMC   1206071 . PMID   7982575.
8. Fan HY, Cheng KK, Klein HL (March 1996). "Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae". Genetics. 142 (3): 749–59. doi:10.1093/genetics/142.3.749. PMC   1207016 . PMID   8849885.

Further reading

• Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. doi: 10.1016/S1097-2765(00)80178-1 . PMID   10024883.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–1765. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Brower CS, Sato S, Tomomori-Sato C, et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353–10358. Bibcode:2002PNAS...9910353B. doi: 10.1073/pnas.162424199 . PMC   124918 . PMID   12149480.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–15127. doi: 10.1074/jbc.C300054200 . PMID   12584197.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–49674. doi: 10.1074/jbc.C300444200 . PMID   14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–5851. doi: 10.1074/jbc.M312523200 . PMID   14638676.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–691. doi: 10.1016/j.molcel.2004.05.006 . PMID   15175163.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi: 10.1016/j.molcel.2004.09.016 . PMID   15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070.

This article incorporates text from the public domain Pfam and InterPro: IPR008831