| METRN | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | METRN , C16orf23, c380A1.2, meteorin, glial cell differentiation regulator | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610998 MGI: 1917333 HomoloGene: 11432 GeneCards: METRN | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Meteorin, glial cell differentiation regulator is a protein that in humans is encoded by the METRN gene. [5]
Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis. Aligned with its neurotrophic properties Meteorin promotes neurotic outgrowth of cultured dorsal root ganglion sensory neurons via a mechanism that involves satellite glial cells. [6] Meteorin also has been shown to have profound and extremely long-lasting analgesic effects in animal models of inflammatory and neuropathic pain. [7] [8]
The human variant of the protein is currently being developed by the Danish biotechnology company, Hoba Therapeutics, [9] for the treatment of neuropathic pain in humans.
Peripherin is a type III intermediate filament protein expressed mainly in neurons of the peripheral nervous system. It is also found in neurons of the central nervous system that have projections toward peripheral structures, such as spinal motor neurons. Its size, structure, and sequence/location of protein motifs is similar to other type III intermediate filament proteins such as desmin, vimentin and glial fibrillary acidic protein. Like these proteins, peripherin can self-assemble to form homopolymeric filamentous networks, but it can also heteropolymerize with neurofilaments in several neuronal types. This protein in humans is encoded by the PRPH gene. Peripherin is thought to play a role in neurite elongation during development and axonal regeneration after injury, but its exact function is unknown. It is also associated with some of the major neuropathologies that characterize amyotropic lateral sclerosis (ALS), but despite extensive research into how neurofilaments and peripherin contribute to ALS, their role in this disease is still unidentified.
Artemin, also known as enovin or neublastin, is a protein that in humans is encoded by the ARTN gene.
V-erbA-related protein 2 (EAR-2) also known as NR2F6 is a protein that in humans is encoded by the NR2F6 gene. V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA, a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.
Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.
Neurofascin is a protein that in humans is encoded by the NFASC gene.
Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.
Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.
Xylosyltransferase 1 is an enzyme that in humans is encoded by the XYLT1 gene.
Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.
Zinc finger protein 238 is a zinc finger containing transcription factor that in humans is encoded by the ZNF238 gene.
Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.
Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene.
WW domain-containing transcription regulator protein 1 is a protein that in humans is encoded by the WWTR1 gene.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.
Myelin regulatory factor, also known as myelin gene regulatory factor (MRF), is a protein that in humans is encoded by the MYRF gene.
Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells. Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA.
Calponin 3. acidic is a protein that in humans is encoded by the CNN3 gene.
DNA-damage-inducible transcript 4 like (DDIT4L) or regulated in development and DNA damage response 2 (REDD2) is a protein that in humans is encoded by the DDIT4L gene. The gene is located on chromosome 4 or chromosome 3 in human or mouse respectively.
Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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