| MFSD4A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MFSD4A , UNQ3064, MFSD4, major facilitator superfamily domain containing 4A, SLC60A1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2442786 HomoloGene: 45419 GeneCards: MFSD4A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Major facilitator superfamily domain containing 4A is a protein belonging to the MFS Pfam clan. [5] It is an atypical solute carrier, thus a plausible SLC transporter in humans. [6] MFSD4A has been identified in both central and peripheral areas. [7]
Battenin is a protein that in humans is encoded by the CLN3 gene located on chromosome 16. Battenin is not clustered into any Pfam clan, but it is included in the TCDB suggesting that it is a transporter. In humans, it belongs to the atypical SLCs due to its structural and phylogenetic similarity to other SLC transporters.
The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.
Probable low affinity copper uptake protein 2 is a protein that in humans is encoded by the SLC31A2 gene.
Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.
Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.
Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.
Major facilitator superfamily domain-containing protein 2 -- also known as sodium-dependent lysophosphatidylcholine symporter 1 -- is a protein that in humans is encoded by the MFSD2A gene. MFSD2A is a membrane transport protein that is expressed in the endothelium of the blood–brain barrier (BBB) and has an essential role in BBB formation and function. Genetic ablation of MFSD2A results in leaky BBB and increases central nervous system endothelial cell vesicular transcytosis without otherwise affecting tight junctions. MFSD2A is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to AMTF8.
Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.
Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the MFSD8 gene. MFSD8 is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 (AMTF2).
Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.
Unc-93 homolog A is a protein that in humans is encoded by the UNC93A gene.
Major facilitator superfamily domain containing 7 is a protein that in humans is encoded by the MFSD7 gene.
Major facilitator superfamily domain containing 14A is a protein that in humans is encoded by the MFSD14A gene. MFSD14A is an atypical solute carrier of MFS type. HGNC:23363
Major facilitator superfamily domain containing 1 is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier.
Major facilitator superfamily domain containing 3 (MFSD3) is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier located to the neuronal plasma membrane.
Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane. It is a plausible Solute carrier transporter. It transports molybdate anions, and it interacts with GLP-1R.
Major facilitator superfamily domain containing 11 (MFSD11) is an atypical Solute carrier found in plasma membranes.
Major facilitator superfamily domain containing 14B is an atypical solute carrier of MFS type. It locates to intracellular membranes.
Atypical Solute Carrier Families are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families.
Major facilitator superfamily domain-containing protein 9 is a protein that in humans is encoded by the MFSD9 gene. It is a potential solute carrier, and called atypical solute carrier since it is not named according to the SLC nomenclature. It is expressed both in central and peripheral organs.
