MFSD4A

MFSD4A
Identifiers
Aliases	MFSD4A , UNQ3064, MFSD4, major facilitator superfamily domain containing 4A, SLC60A1
External IDs	MGI: 2442786; HomoloGene: 45419; GeneCards: MFSD4A; OMA:MFSD4A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 205,568,885 bp [1] End 205,602,918 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 131,950,544 bp [2] End 131,995,800 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva renal medulla middle temporal gyrus Brodmann area 46 nasal epithelium Brodmann area 23 mucosa of sigmoid colon endothelial cell superior frontal gyrus entorhinal cortex Top expressed in epithelium of stomach left colon submandibular gland transitional epithelium of urinary bladder aortic valve ascending aorta parotid gland olfactory epithelium cervix mucous cell of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function glucose transmembrane transporter activity Cellular component membrane integral component of membrane Biological process transmembrane transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 148808 213006 Ensembl ENSG00000174514 ENSMUSG00000059149 UniProt Q8N468 Q6PDC8 RefSeq (mRNA) NM_181644 NM_001114662 NM_172510 RefSeq (protein) NP_857595 NP_001108134 NP_766098 Location (UCSC) Chr 1: 205.57 – 205.6 Mb Chr 1: 131.95 – 132 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Major facilitator superfamily domain containing 4A is a protein belonging to the MFS Pfam clan. ^[5] It is an atypical solute carrier, thus a plausible SLC transporter in humans. ^[6] MFSD4A has been identified in both central and peripheral areas. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000174514 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059149 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC   5627054 . PMID   28878041.
6. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID   27939446.
7. Perland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10) e0186325. Bibcode:2017PLoSO..1286325P. doi: 10.1371/journal.pone.0186325 . PMC   5648162 . PMID   29049335.