MFSD5

MFSD5
Identifiers
Aliases	MFSD5 , hsMOT2, major facilitator superfamily domain containing 5, SLC61A1
External IDs	MGI: 2145901; HomoloGene: 69517; GeneCards: MFSD5; OMA:MFSD5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.13 Start 53,251,251 bp [1] End 53,254,406 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 F2 Start 102,187,889 bp [2] End 102,190,189 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of transverse colon right adrenal cortex granulocyte left adrenal gland left adrenal cortex gums gingival epithelium apex of heart Top expressed in lip stroma of bone marrow transitional epithelium of urinary bladder esophagus right kidney skin of external ear calvaria yolk sac choroid plexus of fourth ventricle granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molybdate ion transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane Biological process molybdate ion transport ion transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84975 106073 Ensembl ENSG00000182544 ENSMUSG00000045665 UniProt Q6N075 Q921Y4 RefSeq (mRNA) NM_001170790 NM_032889 NM_134100 RefSeq (protein) NP_001164261 NP_116278 NP_598861 Location (UCSC) Chr 12: 53.25 – 53.25 Mb Chr 15: 102.19 – 102.19 Mb PubMed search [3] [4]
Wikidata
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Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane. ^[5] It is a plausible Solute carrier transporter. ^[6] It transports molybdate anions, ^[7] and it interacts with GLP-1R. ^[8]

MFSD5 belongs to AMTF6. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000182544 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045665 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6) e0156912. Bibcode:2016PLoSO..1156912P. doi: 10.1371/journal.pone.0156912 . PMC   4896477 . PMID   27272503.
6. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID   27939446.
7. Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi: 10.1073/pnas.1100700108 . PMC   3080982 . PMID   21464289.
8. Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC   5415235 . PMID   23864651.
9. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC   5627054 . PMID   28878041.