MKL2

MRTFB
Identifiers
Aliases	MRTFB , MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2
External IDs	OMIM: 609463 MGI: 3050795 HomoloGene: 40917 GeneCards: MRTFB
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.12 Start 14,071,321 bp [1] End 14,266,773 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A1 Start 13,074,345 bp [2] End 13,235,393 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus Region I of hippocampus proper entorhinal cortex superior frontal gyrus orbitofrontal cortex postcentral gyrus visceral pleura Brodmann area 46 Top expressed in olfactory tubercle piriform cortex nucleus accumbens primary motor cortex cingulate gyrus ventromedial nucleus Region I of hippocampus proper subiculum medullary collecting duct dentate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding cadherin binding Cellular component nucleus Biological process multicellular organism development muscle organ development regulation of transcription, DNA-templated smooth muscle cell differentiation positive regulation of striated muscle tissue development positive regulation of transcription by RNA polymerase II cell differentiation transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57496 239719 Ensembl ENSG00000186260 ENSMUSG00000009569 UniProt Q9ULH7 P59759 RefSeq (mRNA) NM_001308142 NM_014048 NM_001122667 NM_153588 NM_181860 RefSeq (protein) NP_001295071 NP_054767 NP_001352340 NP_001352341 NP_001352342 NP_001352343 NP_001352344 NP_001352345 NP_001352346 NP_001352347 NP_001352348 NP_001352349 NP_001352350 NP_001116139 NP_705816 NP_862908 Location (UCSC) Chr 16: 14.07 – 14.27 Mb Chr 16: 13.07 – 13.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene. ^{[5] [6]}

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function ^[7] and addiction. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000186260 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009569 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
6. "Entrez Gene: MKL2 MKL/myocardin-like 2".
7. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (September 2016). "Emerging roles of the myocardin family of proteins in lipid and glucose metabolism". J Physiol. 594 (17): 4741–4752. doi:10.1113/JP271913. PMC   5009794 . PMID   27060572.
8. Ariza A, Funahashi Y, Kozawa S, Faruk MO, Nagai T, Amano M, Kaibuchi K (2021). "Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK". Journal of Neurochemistry. 157 (6): 1774–1788. doi:10.1111/jnc.15303. PMID   33449379. S2CID   231613803.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14855–60. Bibcode:2002PNAS...9914855W. doi: 10.1073/pnas.222561499 . PMC   137508 . PMID   12397177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cen B, Selvaraj A, Burgess RC, et al. (2003). "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes". Mol. Cell. Biol. 23 (18): 6597–608. doi:10.1128/MCB.23.18.6597-6608.2003. PMC   193697 . PMID   12944485.
• Selvaraj A, Prywes R (2004). "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation". J. Biol. Chem. 278 (43): 41977–87. doi: 10.1074/jbc.M305679200 . PMID   14565952.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Morita T, Mayanagi T, Sobue K (2007). "Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling". J. Cell Biol. 179 (5): 1027–42. doi:10.1083/jcb.200708174. PMC   2099179 . PMID   18056415.