ML-154

ML-154

Clinical data
ATC code	none
Identifiers
IUPAC name 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
CAS Number	1345964-89-7
PubChem CID	46930969
ChemSpider	26360842
UNII	QF6BKX96N5
CompTox Dashboard (EPA)	DTXSID901032908
Chemical and physical data
Formula	C29H26BrN2PS
Molar mass	545.48 g·mol−1
3D model (JSmol)	Interactive image
SMILES [Br-].C1(=CC=CC=C1)[P](=S)(C2=C([N+](=C3C=CC=C[N]23)C\C=C\C4=CC=CC=C4)C)C5=CC=CC=C5
InChI InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+; Key:CJAQCMBWGUOBIX-ZUQRMPMESA-M

ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR. ^[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism. ^[2]

See also

• Neuropeptide S receptor

References

1. Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, et al. (November 2013). "Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor". Journal of Medicinal Chemistry. 56 (22): 9045–56. doi:10.1021/jm400904m. PMC   4877059 . PMID   24171469.
2. Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, et al. (June 2013). "A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats". The Journal of Neuroscience. 33 (24): 10132–42. doi: 10.1523/JNEUROSCI.4742-12.2013 . PMC   3682378 . PMID   23761908.