MLLT10

MLLT10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DAG, 5DAH
Identifiers
Aliases	MLLT10 , AF10, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, histone lysine methyltransferase DOT1L cofactor, MLLT10 histone lysine methyltransferase DOT1L cofactor
External IDs	OMIM: 602409 MGI: 1329038 HomoloGene: 20973 GeneCards: MLLT10
Gene location (Human)
Chr.	Chromosome 10 (human)
End	21,743,630 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	18,212,388 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; sperm; ; tibia; ; superficial temporal artery; ; sural nerve; ; skin of abdomen; ; gastric mucosa; ; ganglionic eminence; ; canal of the cervix;
	Top expressed in
	spermatocyte; ; secondary oocyte; ; seminiferous tubule; ; spermatid; ; thymus; ; abdominal wall; ; ganglionic eminence; ; Paneth cell; ; atrioventricular valve; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity ; DNA binding ; protein binding ; metal ion binding ; chromatin binding ; nucleosome binding ; histone binding ;
Cellular component	nucleoplasm ; nucleus ; cytosol ; protein-containing complex ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	8028
	17354
	ENSG00000078403
	ENSMUSG00000026743
	P55197
	O54826
NM_001009569 ; NM_001195626 ; NM_001195627 ; NM_001195628 ; NM_001195630 ;
	NM_004641 ; NM_001324296 ; NM_001324297
	NM_001252560 ; NM_001252561 ; NM_010804
NP_001182555 ; NP_001182556 ; NP_001182557 ; NP_001182559 ; NP_001311225 ;
	NP_001311226 ; NP_004632
	NP_001239489 ; NP_001239490 ; NP_034934
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 30, 2023

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.^[5]^[6]

Interactions

MLLT10 has been shown to interact with SS18.^[7]

Related Research Articles

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3, receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

Afadin is a protein that in humans is encoded by the AFDN gene.

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.

Protein SSXT is a protein that in humans is encoded by the SS18 gene.

RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.

Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.

AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.

Protein BEX1 also known as brain-expressed X-linked protein 1 is a protein that in humans is encoded by the BEX1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078403 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026743 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. doi: 10.1182/blood.V85.6.1435.bloodjournal8561435 . PMID 7888665.
↑ "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".
↑ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977. S2CID 2364045.

Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides". Leukemia. 12 (9): 1404–10. doi:10.1038/sj.leu.2401109. PMID 9737689. S2CID 5821466.
Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V (2000). "Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation". J. Mol. Biol. 299 (2): 369–78. doi:10.1006/jmbi.2000.3766. PMID 10860745.
Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V (2000). "Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia". Br. J. Haematol. 110 (3): 547–51. doi: 10.1046/j.1365-2141.2000.02212.x . PMID 10997963. S2CID 45898713.
de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977. S2CID 2364045.
Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD (2002). "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex". Blood. 99 (1): 275–81. doi: 10.1182/blood.V99.1.275 . PMID 11756182.
Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Mol. Reprod. Dev. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID 11774384. S2CID 23631919.
Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM (2002). "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia". Cancer Genet. Cytogenet. 135 (2): 187–91. doi:10.1016/S0165-4608(01)00644-6. PMID 12127405.
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E (2002). "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation". Mol. Cell. 10 (5): 1119–28. doi: 10.1016/S1097-2765(02)00740-2 . PMID 12453419.
Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM (2003). "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions". Mol. Cell. Biol. 23 (1): 119–30. doi:10.1128/MCB.23.1.119-130.2003. PMC 140655 . PMID 12482966.
Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y (2005). "hDOT1L links histone methylation to leukemogenesis". Cell. 121 (2): 167–78. doi: 10.1016/j.cell.2005.02.020 . PMID 15851025. S2CID 15638573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000078403 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026743 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7888665-5] Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. doi: 10.1182/blood.V85.6.1435.bloodjournal8561435 . PMID 7888665.

[entrez-6] "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".

[pmid11423977-7] Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977. S2CID 2364045.

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MLLT10

Contents

Interactions

Related Research Articles

References

Further reading