SS18

SS18
Identifiers
Aliases	SS18 , SSXT, SYT, nBAF chromatin remodeling complex subunit, SS18 subunit of BAF chromatin remodeling complex, SMARCL1
External IDs	OMIM: 600192 MGI: 107708 HomoloGene: 38080 GeneCards: SS18
Gene location (Human)
Chr.	Chromosome 18 (human)
End	26,091,217 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	14,815,971 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; left adrenal gland; ; skin of abdomen; ; gallbladder; ; tibial nerve; ; islet of Langerhans; ; left lobe of thyroid gland; ; right coronary artery; ; right lobe of thyroid gland;
	Top expressed in
	esophagus; ; lip; ; yolk sac; ; morula; ; spermatocyte; ; otolith organ; ; utricle; ; hand; ; thymus; ; lens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; nuclear receptor coactivator activity ; transcription coactivator activity ;
Cellular component	cytoplasmic microtubule ; npBAF complex ; nucleus ; SWI/SNF complex ;
Biological process	ephrin receptor signaling pathway ; intracellular signal transduction ; regulation of transcription, DNA-templated ; cytoskeleton organization ; microtubule cytoskeleton organization ; cell morphogenesis ; transcription, DNA-templated ; positive regulation of transcription by RNA polymerase II ; neuronal stem cell population maintenance ; positive regulation of transcription, DNA-templated ; regulation of nucleic acid-templated transcription ; positive regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	6760
	268996
	ENSG00000141380
	ENSMUSG00000037013
	Q15532 ; Q4VAX0
	Q62280
	NM_001007559 ; NM_001308201 ; NM_005637
	NM_001161369 ; NM_001161370 ; NM_001161371 ; NM_009280
	NP_001007560 ; NP_001295130 ; NP_005628 ; NP_005628.2
	NP_001154841 ; NP_001154842 ; NP_001154843 ; NP_033306
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 06, 2024

Protein SSXT is a protein that in humans is encoded by the SS18 gene.^[5]^[6]^[7]

Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex.^[8]^[9]^[10]

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.^[11]

Interactions

SS18 has been shown to interact with:

Related Research Articles

A synovial sarcoma is a rare form of cancer which occurs primarily in the extremities of the arms or legs, often in proximity to joint capsules and tendon sheaths. It is a type of soft-tissue sarcoma.

In molecular biology, SWI/SNF, is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes. In other words, it is a group of proteins that associate to remodel the way DNA is packaged. This complex is composed of several proteins – products of the SWI and SNF genes, as well as other polypeptides. It possesses a DNA-stimulated ATPase activity that can destabilize histone-DNA interactions in reconstituted nucleosomes in an ATP-dependent manner, though the exact nature of this structural change is unknown. The SWI/SNF subfamily provides crucial nucleosome rearrangement, which is seen as ejection and/or sliding. The movement of nucleosomes provides easier access to the chromatin, allowing genes to be activated or repressed.

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family.

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.

ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatin remodeling complex.

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.

Synovial sarcoma, X breakpoint (SSX) refers to a group of genes rearranged in synovial sarcoma.

Biphenotypic sinonasal sarcoma is a newly recognized, very rare, low-grade malignant tumor of the nasal cavity, which was formerly probably included in fibrosarcoma and synovial sarcoma cases. It was incorporated into the fourth edition of the World Health Organization Classification of Head and Neck Tumours, published in 2017.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141380 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037013 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene. 9 (5): 1447–53. PMID 8152806.
↑ Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320. S2CID 20503729.
↑ de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research. 112 (3–4): 222–6. doi:10.1159/000089874. PMID 16484776.
↑ Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. Bibcode:2012PLoSO...733834M. doi: 10.1371/journal.pone.0033834 . PMC 3307773 . PMID 22442726.
1 2 Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . hdl: 2066/170683 . PMID 11734557.
1 2 Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi: 10.1038/sj.onc.1207031 . PMID 14603256.
↑ Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi: 10.1038/sj.onc.1205569 . PMID 12037676.
↑ Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi: 10.1016/S0092-8674(00)00072-6 . PMID 11030627. S2CID 17342132.
↑ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi: 10.1038/sj.onc.1204419 . PMID 11423977.

Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (Dec 1995). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". The American Journal of Pathology. 147 (6): 1592–9. PMC 1869933 . PMID 7495284.
Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi: 10.1093/hmg/6.9.1559 . PMID 9285794.
Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G (Apr 1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Human Molecular Genetics. 8 (4): 585–91. doi: 10.1093/hmg/8.4.585 . PMID 10072425.
Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi: 10.1016/S0092-8674(00)00072-6 . PMID 11030627. S2CID 17342132.
Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S (Apr 2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". British Journal of Cancer. 84 (8): 1087–94. doi:10.1054/bjoc.2000.1710. PMC 2363857 . PMID 11308259.
Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O (May 2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene. 268 (1–2): 173–82. doi:10.1016/S0378-1119(01)00412-7. PMID 11368913.
de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi: 10.1038/sj.onc.1204419 . PMID 11423977.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" (PDF). Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163 . PMID 11591653.
Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . hdl: 2066/170683 . PMID 11734557.
Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi: 10.1038/sj.onc.1205569 . PMID 12037676.
Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A (Aug 2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Experimental Cell Research. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi: 10.1038/sj.onc.1207031 . PMID 14603256.
Iwasaki T, Koibuchi N, Chin WW (Sep 2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology. 146 (9): 3892–9. doi: 10.1210/en.2004-1513 . PMID 15919756.
Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M (Mar 2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". International Journal of Cancer. 118 (5): 1165–72. doi: 10.1002/ijc.21475 . PMID 16152617. S2CID 12084422.
Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Dec 2005). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". The Journal of Biological Chemistry. 280 (52): 42863–76. doi: 10.1074/jbc.M502963200 . PMID 16227627.
Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S (Feb 2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene. 25 (7): 1042–52. doi: 10.1038/sj.onc.1209143 . PMID 16247461.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141380 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037013 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8152806-5] Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene. 9 (5): 1447–53. PMID 8152806.

[pmid7951320-6] Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320. S2CID 20503729.

[pmid16484776-7] Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research. 112 (3–4): 222–6. doi:10.1159/000089874. PMID 16484776.

[pmid22442726-8] Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. Bibcode:2012PLoSO...733834M. doi: 10.1371/journal.pone.0033834 . PMC 3307773 . PMID 22442726.

[pmid11734557-9] 1 2 Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . hdl: 2066/170683 . PMID 11734557.

[pmid14603256-10] 1 2 Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi: 10.1038/sj.onc.1207031 . PMID 14603256.

[pmid12037676-11] Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi: 10.1038/sj.onc.1205569 . PMID 12037676.

[pmid11030627-12] Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi: 10.1016/S0092-8674(00)00072-6 . PMID 11030627. S2CID 17342132.

[pmid11423977-13] Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi: 10.1038/sj.onc.1204419 . PMID 11423977.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]