SS18

SS18
Identifiers
Aliases	SS18 , SSXT, SYT, nBAF chromatin remodeling complex subunit, SS18 subunit of BAF chromatin remodeling complex, SMARCL1
External IDs	OMIM: 600192; MGI: 107708; HomoloGene: 38080; GeneCards: SS18; OMA:SS18 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q11.2 Start 26,016,253 bp [1] End 26,091,217 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 A1 Start 14,757,255 bp [2] End 14,815,971 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex stromal cell of endometrium left ovary Achilles tendon left adrenal gland right ovary left adrenal cortex skin of abdomen gallbladder tibial nerve Top expressed in zygote ventricular zone esophagus tail of embryo genital tubercle lip yolk sac right kidney morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear receptor coactivator activity transcription coactivator activity Cellular component cytoplasmic microtubule npBAF complex nucleus SWI/SNF complex Biological process ephrin receptor signaling pathway intracellular signal transduction regulation of transcription, DNA-templated cytoskeleton organization microtubule cytoskeleton organization cell morphogenesis transcription, DNA-templated positive regulation of transcription by RNA polymerase II neuronal stem cell population maintenance positive regulation of transcription, DNA-templated regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6760 268996 Ensembl ENSG00000141380 ENSMUSG00000037013 UniProt Q15532 Q4VAX0 Q62280 RefSeq (mRNA) NM_001007559 NM_001308201 NM_005637 NM_001161369 NM_001161370 NM_001161371 NM_009280 RefSeq (protein) NP_001007560 NP_001295130 NP_005628 NP_005628.2 NP_001154841 NP_001154842 NP_001154843 NP_033306 Location (UCSC) Chr 18: 26.02 – 26.09 Mb Chr 18: 14.76 – 14.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SSXT is a protein that in humans is encoded by the SS18 gene. ^{[5] [6] [7]}

Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex. ^{[8] [9] [10]}

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma. ^[11]

Interactions

SS18 has been shown to interact with:

• EP300, ^[12]
• MLLT10, ^[13]
• SMARCA2, ^[10] and
• SMARCB1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000141380 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037013 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene. 9 (5): 1447–53. PMID   8152806.
6. Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID   7951320. S2CID   20503729.
7. de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research. 112 (3–4): 222–6. doi:10.1159/000089874. PMID   16484776.
8. Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3) e33834. Bibcode:2012PLoSO...733834M. doi: 10.1371/journal.pone.0033834 . PMC   3307773 . PMID   22442726.
9. Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . hdl: 2066/170683 . PMID   11734557.
10. Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi: 10.1038/sj.onc.1207031 . PMID   14603256.
11. Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi: 10.1038/sj.onc.1205569 . PMID   12037676.
12. Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi: 10.1016/S0092-8674(00)00072-6 . PMID   11030627. S2CID   17342132.
13. de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi: 10.1038/sj.onc.1204419 . PMID   11423977.

Further reading

• Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (Dec 1995). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". The American Journal of Pathology. 147 (6): 1592–9. PMC   1869933 . PMID   7495284.
• Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi: 10.1093/hmg/6.9.1559 . PMID   9285794.
• Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G (Apr 1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Human Molecular Genetics. 8 (4): 585–91. doi: 10.1093/hmg/8.4.585 . PMID   10072425.
• Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi: 10.1016/S0092-8674(00)00072-6 . PMID   11030627. S2CID   17342132.
• Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S (Apr 2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". British Journal of Cancer. 84 (8): 1087–94. doi:10.1054/bjoc.2000.1710. PMC   2363857 . PMID   11308259.
• Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O (May 2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene. 268 (1–2): 173–82. doi:10.1016/S0378-1119(01)00412-7. PMID   11368913.
• de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi: 10.1038/sj.onc.1204419 . PMID   11423977.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" (PDF). Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . hdl: 2066/170683 . PMID   11734557.
• Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi: 10.1038/sj.onc.1205569 . PMID   12037676.
• Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A (Aug 2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Experimental Cell Research. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID   12878157.
• Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi: 10.1038/sj.onc.1207031 . PMID   14603256.
• Iwasaki T, Koibuchi N, Chin WW (Sep 2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology. 146 (9): 3892–9. doi: 10.1210/en.2004-1513 . PMID   15919756.
• Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M (Mar 2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". International Journal of Cancer. 118 (5): 1165–72. doi: 10.1002/ijc.21475 . PMID   16152617. S2CID   12084422.
• Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Dec 2005). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". The Journal of Biological Chemistry. 280 (52): 42863–76. doi: 10.1074/jbc.M502963200 . PMID   16227627.
• Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S (Feb 2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene. 25 (7): 1042–52. doi: 10.1038/sj.onc.1209143 . PMID   16247461.