MPDZ

MPDZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FCF, 2FNE, 2IWN, 2IWO, 2IWP, 2IWQ, 2O2T, 2OPG, 2QG1 Contents Interactions ; References ; Further reading ;
Identifiers
Aliases	MPDZ , HYC2, MUPP1, multiple PDZ domain crumbs cell polarity complex component
External IDs	OMIM: 603785 MGI: 1343489 HomoloGene: 2841 GeneCards: MPDZ
Gene location (Human)
Chr.	Chromosome 9 (human)
End	13,279,590 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	81,442,815 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; superior vestibular nucleus; ; vena cava; ; urethra; ; retinal pigment epithelium; ; right ventricle;
	Top expressed in
	digastric muscle; ; sciatic nerve; ; vastus lateralis muscle; ; iris; ; vas deferens; ; thoracic diaphragm; ; dermis; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; intercostal muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding ; protein binding ;
Cellular component	cytoplasm ; neuron projection ; cell junction ; apicolateral plasma membrane ; dendrite ; postsynaptic membrane ; plasma membrane ; cell projection ; synapse ; apical plasma membrane ; Schmidt-Lanterman incisure ; cytoplasmic vesicle ; postsynaptic density ; membrane ; bicellular tight junction ;
Biological process	cell adhesion ; viral process ;
	Sources:Amigo / QuickGO
Orthologs
	8777
	17475
	ENSG00000107186
	ENSMUSG00000028402
	O75970
	Q8VBX6
	NM_001261406 ; NM_001261407 ; NM_003829 ; NM_001330637
	NM_010820 ; NM_001305284 ; NM_001305286
NP_001248335 ; NP_001248336 ; NP_001317566 ; NP_003820 ; NP_001362342 ;
	NP_001362345 ; NP_001362346 ; NP_001362347 ; NP_001362348 ; NP_001362349 ; NP_001362350 ; NP_001362351 ; NP_001362352 ; NP_001362353 ; NP_001362354 ; NP_001362355 ; NP_001362356 ; NP_001365707
	NP_001292213 ; NP_001292215 ; NP_034950
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 09, 2023

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.^[5]

Interactions

MPDZ has been shown to interact with:

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107186 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028402 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MPDZ multiple PDZ domain protein".
↑ Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi: 10.1074/jbc.M008089200 . PMID 11150294.
↑ Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. doi: 10.1016/s0014-5793(98)00141-0 . PMID 9537516. S2CID 25328791.
↑ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. doi:10.1016/s0014-5793(00)02036-6. PMID 11018522. S2CID 40159587.
↑ Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (February 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335 . PMID 11802782.

Ullmer C, Schmuck K, Figge A, Lübbert H (1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. doi: 10.1016/S0014-5793(98)00141-0 . PMID 9537516. S2CID 25328791.
Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2". J. Cell. Biochem. 79 (2): 213–24. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMC 3501957 . PMID 10967549.
Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT (2000). "Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins". J. Virol. 74 (20): 9680–93. doi:10.1128/JVI.74.20.9680-9693.2000. PMC 112400 . PMID 11000240.
Mancini A, Koch A, Stefan M, Niemann H, Tamura T (2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. doi:10.1016/S0014-5793(00)02036-6. PMID 11018522. S2CID 40159587.
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi: 10.1074/jbc.M008089200 . PMID 11150294.
Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800 . PMID 11358867.
Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S (2002). "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". J. Biol. Chem. 277 (1): 455–61. doi: 10.1074/jbc.M109005200 . PMID 11689568.
Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335 . PMID 11802782.
Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E (2002). "Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells". J. Cell Biol. 159 (2): 361–72. doi:10.1083/jcb.200207050. PMC 2173042 . PMID 12403818.
Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE (2004). "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation". Neuron. 43 (4): 563–74. doi: 10.1016/j.neuron.2004.08.003 . PMID 15312654. S2CID 17190912.
van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger MW, Rashbass P, Le Bivic A, Wijnholds J (2005). "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure". J. Cell Sci. 117 (Pt 18): 4169–77. doi: 10.1242/jcs.01301 . PMID 15316081.
Coyne CB, Voelker T, Pichla SL, Bergelson JM (2005). "The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction". J. Biol. Chem. 279 (46): 48079–84. doi: 10.1074/jbc.M409061200 . PMID 15364909.
Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. doi: 10.1074/jbc.M510187200 . PMID 16192269.
Heydecke D, Meyer D, Ackermann F, Wilhelm B, Gudermann T, Boekhoff I (2006). "The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa". J. Androl. 27 (3): 390–404. doi: 10.2164/jandrol.05166 . PMID 16452527.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985 . PMID 17672918.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107186 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028402 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MPDZ multiple PDZ domain protein".

[pmid11150294-6] Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi: 10.1074/jbc.M008089200 . PMID 11150294.

[pmid9537516-7] Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. doi: 10.1016/s0014-5793(98)00141-0 . PMID 9537516. S2CID 25328791.

[pmid11018522-8] Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. doi:10.1016/s0014-5793(00)02036-6. PMID 11018522. S2CID 40159587.

[pmid11802782-9] Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (February 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335 . PMID 11802782.

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MPDZ

Contents

Interactions

Related Research Articles

References

Further reading