MPHOSPH10

MPHOSPH10
Identifiers
Aliases	MPHOSPH10 , CT90, MPP10, MPP10P, PPP1R106, M-phase phosphoprotein 10
External IDs	OMIM: 605503 MGI: 1915223 HomoloGene: 134741 GeneCards: MPHOSPH10
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.3 Start 71,130,310 bp [1] End 71,150,101 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 C Start 64,026,275 bp [2] End 64,042,016 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon endometrium oral cavity pericardium hair follicle gastrocnemius muscle body of tongue thoracic diaphragm ganglionic eminence superior surface of tongue Top expressed in secondary oocyte primitive streak morula somite crypt of lieberkuhn of small intestine spermatocyte hair follicle lacrimal gland intercostal muscle cheek More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component sno(s)RNA-containing ribonucleoprotein complex small-subunit processome Mpp10 complex nucleolus nucleus chromosome nucleoplasm Biological process RNA splicing, via transesterification reactions negative regulation of phosphatase activity RNA processing ribosome biogenesis RNA splicing rRNA processing maturation of SSU-rRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10199 67973 Ensembl ENSG00000124383 ENSMUSG00000030521 UniProt O00566 Q810V0 RefSeq (mRNA) NM_005791 NM_026483 RefSeq (protein) NP_005782 NP_080759 Location (UCSC) Chr 2: 71.13 – 71.15 Mb Chr 7: 64.03 – 64.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U3 small nucleolar ribonucleoprotein protein MPP10 is a protein that in humans is encoded by the MPHOSPH10 gene. ^{[5] [6] [7]}

This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000124383 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030521 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC   275994 . PMID   8885239.
6. Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ (Mar 1998). "M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component". Mol Biol Cell. 9 (2): 437–49. doi:10.1091/mbc.9.2.437. PMC   25272 . PMID   9450966.
7. "Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)".

Further reading

• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes". Nucleic Acids Res. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC   152815 . PMID   12655004.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• MPHOSPH10 human gene location in the UCSC Genome Browser .
• MPHOSPH10 human gene details in the UCSC Genome Browser .