MPP5

PALS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y76, 3UIT, 4UU5, 4UU6, 4WSI
Identifiers
Aliases	PALS1 , membrane palmitoylated protein 5, protein associated with LIN7 1, MAGUK p55 family member, MPP5, protein associated with LIN7 1, MAGUK family member
External IDs	OMIM: 606958 MGI: 1927339 HomoloGene: 9512 GeneCards: PALS1
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.3 Start 67,240,713 bp [1] End 67,336,061 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 78,795,681 bp [2] End 78,887,488 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa germinal epithelium retinal pigment epithelium corpus callosum inferior ganglion of vagus nerve biceps brachii amniotic fluid corpus epididymis superior vestibular nucleus endothelial cell Top expressed in spermatid otic placode saccule secondary oocyte left lung lobe interventricular septum right lung intestinal villus seminal vesicula masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein binding Cellular component cytoplasm membrane bicellular tight junction myelin sheath adaxonal region Schmidt-Lanterman incisure cell junction lateral loop extracellular exosome endomembrane system plasma membrane protein-containing complex Biological process establishment of epithelial cell polarity peripheral nervous system myelin maintenance protein localization to myelin sheath abaxonal region myelin assembly bicellular tight junction assembly plasma membrane organization morphogenesis of an epithelial sheet protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64398 56217 Ensembl ENSG00000072415 ENSMUSG00000021112 UniProt Q8N3R9 Q9JLB2 RefSeq (mRNA) NM_001256550 NM_022474 NM_019579 RefSeq (protein) NP_001243479 NP_071919 NP_062525 Location (UCSC) Chr 14: 67.24 – 67.34 Mb Chr 12: 78.8 – 78.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene. ^{[5] [6]} Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM] ^[6]

Interactions

MPP5 has been shown to interact with INADL and FAM71D. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000072415 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021112 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC   2173254 . PMID   11927608.
6. "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi: 10.1074/jbc.275.15.11425 . PMID   10753959.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID   11311936.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID   12527193.
• Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID   12545177. S2CID   25212419.
• Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID   12771187. S2CID   4482921.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Penkert RR, DiVittorio HM, Prehoda KE (2004). "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex". Nat. Struct. Mol. Biol. 11 (11): 1122–7. doi:10.1038/nsmb839. PMC   2140275 . PMID   15475968.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Stöhr H, Molday LL, Molday RS, et al. (2005). "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina" (PDF). J. Comp. Neurol. 481 (1): 31–41. doi:10.1002/cne.20367. PMID   15558731. S2CID   19904556.
• Feng W, Long JF, Zhang M (2005). "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6861–6. Bibcode:2005PNAS..102.6861F. doi: 10.1073/pnas.0409346102 . PMC   1100767 . PMID   15863617.
• Kantardzhieva A, Gosens I, Alexeeva S, et al. (2005). "MPP5 recruits MPP4 to the CRB1 complex in photoreceptors". Invest. Ophthalmol. Vis. Sci. 46 (6): 2192–201. doi:10.1167/iovs.04-1417. PMID   15914641.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.