MRPS18A

MRPS18A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPS18A , HumanS18b, MRP-S18-3, MRPS18-3, S18bmt, mitochondrial ribosomal protein S18A, S18mt-a, MRP-S18-a
External IDs	OMIM: 611981 MGI: 1915815 HomoloGene: 32391 GeneCards: MRPS18A
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.1 Start 43,671,202 bp [1] End 43,687,791 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 C Start 46,421,912 bp [2] End 46,439,836 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle body of stomach rectum left ventricle endothelial cell Right adrenal gland right lobe of liver Left adrenal gland parotid gland skeletal muscle tissue Top expressed in seminal vesicula yolk sac interventricular septum soleus muscle right ventricle intercostal muscle digastric muscle temporal muscle morula sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome small ribosomal subunit rRNA binding Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrion mitochondrial small ribosomal subunit cytosolic small ribosomal subunit mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55168 68565 Ensembl ENSG00000096080 ENSMUSG00000023967 UniProt Q9NVS2 Q99N85 RefSeq (mRNA) NM_001193343 NM_018135 NM_026768 RefSeq (protein) NP_001180272 NP_060605 NP_081044 Location (UCSC) Chr 6: 43.67 – 43.69 Mb Chr 17: 46.42 – 46.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S18a, mitochondrial is a protein that in humans is encoded by the MRPS18A gene. ^{[5] [6] [7]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000096080 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023967 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
6. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
7. "Entrez Gene: MRPS18A mitochondrial ribosomal protein S18A".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.