MRPS18B

MRPS18B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS18B , C6orf14, HSPC183, HumanS18a, MRP-S18-2, MRPS18-2, PTD017, S18amt, mitochondrial ribosomal protein S18B
External IDs	OMIM: 611982 MGI: 1914223 HomoloGene: 32205 GeneCards: MRPS18B
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 30,617,840 bp [1] End 30,626,395 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 36,221,271 bp [2] End 36,227,281 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue left ventricle islet of Langerhans kidney rectum Right adrenal gland body of pancreas right lobe of liver Left adrenal gland Top expressed in morula blastocyst proximal tubule adrenal gland white adipose tissue placenta quadriceps femoris muscle muscle tissue yolk sac liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding Cellular component cell junction ribosome nucleoplasm intracellular anatomical structure mitochondrial inner membrane mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation protein biosynthesis mitochondrial translational termination mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28973 66973 Ensembl ENSG00000229861 ENSG00000226111 ENSG00000204568 ENSG00000203624 ENSG00000227420 ENSG00000233813 ENSG00000223775 ENSMUSG00000024436 UniProt Q9Y676 Q99N84 RefSeq (mRNA) NM_014046 NM_025878 NM_001347380 NM_001361453 NM_001361454 NM_001361455 RefSeq (protein) NP_054765 NP_001334309 NP_080154 NP_001348382 NP_001348383 NP_001348384 Location (UCSC) Chr 6: 30.62 – 30.63 Mb Chr 17: 36.22 – 36.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S18b, mitochondrial is a protein that in humans is encoded by the MRPS18B gene. ^{[5] [6]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.

Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. ^[6]

References

1. ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 GRCh38: Ensembl release 89: ENSG00000229861, ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024436 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
6. "Entrez Gene: MRPS18B mitochondrial ribosomal protein S18B".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC   1526686 . PMID   16702430.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.