MSTO1

MSTO1
Identifiers
Aliases	MSTO1 , MST, LST005, misato 1, mitochondrial distribution and morphology regulator, MMYAT, misato mitochondrial distribution and morphology regulator 1
External IDs	OMIM: 617619 MGI: 2385175 HomoloGene: 41228 GeneCards: MSTO1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,614,951 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,821,306 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; tibial nerve; ; right uterine tube; ; right lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; body of pancreas; ; sural nerve; ; left lobe of thyroid gland;
	Top expressed in
	spermatid; ; yolk sac; ; spermatocyte; ; seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; primitive streak; ; renal corpuscle; ; mirror; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function ;
Cellular component	mitochondrial outer membrane ; mitochondrion ; membrane ; cytoplasm ;
Biological process	mitochondrion organization ; mitochondrion distribution ; mitochondrial genome maintenance ; mitotic sister chromatid segregation ; mitotic spindle assembly ;
	Sources:Amigo / QuickGO
Orthologs
	55154
	229524
	ENSG00000125459
	ENSMUSG00000068922
	Q9BUK6
	Q2YDW2
NM_001256532 ; NM_001256533 ; NM_018116 ; NM_001350772 ; NM_001350773 ;
	NM_001350774 ; NM_001350775 ; NM_001350776 ; NM_001350777 ; NM_001350778 ; NM_001350779 ; NM_001350780 ; NM_001350781 ; NM_001350782 ; NM_001350783 ; NM_001350784 ; NM_001350785 ; NM_001350786 ; NM_001350787 ; NM_001350788 ; NM_001350789 Contents Structure ; References ; Further reading ;
	NM_144898
NP_001243461 ; NP_001243462 ; NP_060586 ; NP_001337701 ; NP_001337702 ;
	NP_001337703 ; NP_001337704 ; NP_001337705 ; NP_001337706 ; NP_001337707 ; NP_001337708 ; NP_001337709 ; NP_001337710 ; NP_001337711 ; NP_001337712 ; NP_001337713 ; NP_001337714 ; NP_001337715 ; NP_001337716 ; NP_001337717 ; NP_001337718
	NP_659147
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Protein misato homolog 1 is a protein that in humans is encoded by the MSTO1 gene.^[5]^[6]

The MSTO1 gene is 5134 base pairs (located in chromosome 1) and the MSTO1 protein is 570 aminoacids in length. It is located in the outer membrane of the mitochondrion, and is involved in the regulation of mitochondrial distribution and morphology.^[7]

Structure

The misato protein contains an N-terminal misato segment II myosin-like domain and a central tubulin domain.^[7]

Related Research Articles

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

Frizzled-2(Fz-2) is a protein that in humans is encoded by the FZD2 gene.

Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.

Frizzled-7(Fd-7) is a protein that in humans is encoded by the FZD7 gene.

Frizzled-8(Fz-8) is a protein that in humans is encoded by the FZD8 gene.

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.

39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.

60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.

Protein MTO1 homolog, mitochondrial is a protein that in humans is encoded by the MTO1 gene.

Zinc finger protein 64 homolog, isoforms 1 and 2 is a protein that in humans is encoded by the ZFP64 gene.

39S ribosomal protein L32, mitochondrial is a protein that in humans is encoded by the MRPL32 gene.

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene.

The Misato segment II myosin-like domain is an evolutionary conserved protein domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125459 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068922 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (Jul 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi: 10.1016/j.ygeno.2006.02.002 . PMID 16545939.
↑ "Entrez Gene: MSTO1 misato homolog 1 (Drosophila)".
1 2 Kimura M, Okano Y (April 2007). "Human Misato regulates mitochondrial distribution and morphology". Exp. Cell Res. 313 (7): 1393–404. doi:10.1016/j.yexcr.2007.02.004. PMID 17349998.

MSTO1

Contents

Structure

Related Research Articles

References

Further reading