MTFMT

Last updated
MTFMT
Identifiers
Aliases MTFMT , COXPD15, FMT1, mitochondrial methionyl-tRNA formyltransferase, MC1DN27
External IDs OMIM: 611766 MGI: 1916856 HomoloGene: 12320 GeneCards: MTFMT
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139242

NM_027134

RefSeq (protein)

NP_640335

NP_081410

Location (UCSC) Chr 15: 65 – 65.03 Mb Chr 9: 65.34 – 65.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial methionyl-tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene. [5]

The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [5] Recessive-type mutations in MTFMT have been shown to cause mitochondrial disease. [6]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103707 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059183 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: Mitochondrial methionyl-tRNA formyltransferase" . Retrieved 2011-09-20.
  6. Tucker EJ, Hershman SG, Köhrer C, Belcher-Timme CA, Patel J, Goldberger OA, et al. (September 2011). "Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation". Cell Metabolism. 14 (3): 428–434. doi:10.1016/j.cmet.2011.07.010. PMC   3486727 . PMID   21907147.

Further reading