MTO1

MTO1
Identifiers
Aliases	MTO1 , COXPD10, CGI-02, mitochondrial tRNA translation optimization 1
External IDs	OMIM: 614667 MGI: 1915541 HomoloGene: 5876 GeneCards: MTO1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,509,236 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	78,382,630 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; sperm; ; endothelial cell; ; right lobe of liver; ; Achilles tendon; ; kidney tubule; ; right ventricle; ; tibia; ; biceps brachii; ; parietal pleura;
	Top expressed in
	proximal tubule; ; spermatocyte; ; medullary collecting duct; ; quadriceps femoris muscle; ; triceps surae; ; gastrocnemius muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	flavin adenine dinucleotide binding ; RNA binding ;
Cellular component	mitochondrion ;
Biological process	tRNA methylation ; mitochondrial tRNA wobble uridine modification ; tRNA processing ; tRNA wobble uridine modification ;
	Sources:Amigo / QuickGO
Orthologs
	25821
	68291
	ENSG00000135297
	ENSMUSG00000032342
	Q9Y2Z2
	Q923Z3
	NM_001123226 ; NM_012123 ; NM_133645
	NM_026658
	NP_001116698 ; NP_036255 ; NP_598400
	NP_080934
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Protein MTO1 homolog, mitochondrial is a protein that in humans is encoded by the MTO1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135297 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032342 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Li X, Li R, Lin X, Guan MX (Jul 2002). "Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation". J Biol Chem. 277 (30): 27256–64. doi: 10.1074/jbc.M203267200 . PMID 12011058.
↑ "Entrez Gene: MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bykhovskaya Y, Mengesha E, Wang D, et al. (2005). "Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3". Mol. Genet. Metab. 83 (3): 199–206. doi:10.1016/j.ymgme.2004.07.009. PMID 15542390.
Krull M, Brosius J, Schmitz J (2005). "Alu-SINE exonization: en route to protein-coding function". Mol. Biol. Evol. 22 (8): 1702–11. doi: 10.1093/molbev/msi164 . PMID 15901843.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135297 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032342 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12011058-5] Li X, Li R, Lin X, Guan MX (Jul 2002). "Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation". J Biol Chem. 277 (30): 27256–64. doi: 10.1074/jbc.M203267200 . PMID 12011058.

[entrez-6] "Entrez Gene: MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae)".

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MTO1

Related Research Articles

References

Further reading