MTPN

MTPN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AAA
Identifiers
Aliases	MTPN , GCDP, V-1, myotrophin
External IDs	OMIM: 606484 MGI: 99445 HomoloGene: 40607 GeneCards: MTPN
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q33 Start 135,926,760 bp [1] End 135,977,359 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B1 Start 35,485,841 bp [2] End 35,516,823 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery monocyte lower lobe of lung spongy bone Brodmann area 46 tibialis anterior muscle postcentral gyrus oral cavity trigeminal ganglion spinal ganglia Top expressed in retinal pigment epithelium barrel cortex ciliary body subiculum prefrontal cortex pineal gland olfactory tubercle calvaria iris abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding Cellular component cytoplasm F-actin capping protein complex axon perinuclear region of cytoplasm nucleus cytosol Biological process regulation of striated muscle tissue development catecholamine metabolic process positive regulation of cardiac muscle hypertrophy regulation of barbed-end actin filament capping cellular response to mechanical stimulus skeletal muscle tissue regeneration neuron differentiation striated muscle cell differentiation regulation of translation cerebellar granule cell differentiation positive regulation of NF-kappaB transcription factor activity positive regulation of cell growth positive regulation of macromolecule biosynthetic process regulation of cell size Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 136319 14489 Ensembl ENSG00000105887 ENSMUSG00000029840 UniProt P58546 P62774 RefSeq (mRNA) NM_145808 NM_008098 RefSeq (protein) NP_665807 NP_032124 Location (UCSC) Chr 7: 135.93 – 135.98 Mb Chr 6: 35.49 – 35.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myotrophin is a protein that in humans is encoded by the MTPN gene. ^{[5] [6]}

Interactions

MTPN has been shown to interact with RELA ^[7] and REL. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000105887 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029840 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID   11474205. S2CID   30646120.
6. "Entrez Gene: MTPN myotrophin".
7. Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. United States. 277 (26): 23888–97. doi: 10.1074/jbc.M202937200 . ISSN   0021-9258. PMID   11971907.

Further reading

• Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif". Eur. J. Biochem. 207 (2): 615–20. doi: 10.1111/j.1432-1033.1992.tb17088.x . PMID   1633812.
• Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. doi: 10.1161/01.res.73.1.98 . PMID   8508536.
• Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro". J. Biol. Chem. 271 (5): 2812–6. doi: 10.1074/jbc.271.5.2812 . PMID   8576259.
• Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol. 31 (4): 705–19. doi:10.1006/jmcc.1998.0903. PMID   10329199.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26): 23888–97. doi: 10.1074/jbc.M202937200 . PMID   11971907.
• Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta. 1589 (3): 247–60. doi:10.1016/S0167-4889(02)00178-7. PMID   12031792.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions". J. Immunol. 177 (7): 4907–16. doi:10.4049/jimmunol.177.7.4907. PMC   3902139 . PMID   16982933.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.