MTRF1L

MTRF1L
Identifiers
Aliases	MTRF1L , HMRF1L, MRF1L, mtRF1a, mitochondrial translational release factor 1 like, mitochondrial translation release factor 1 like, Mitochondrial translational release factor 1-like
External IDs	OMIM: 613542; MGI: 1918830; HomoloGene: 5905; GeneCards: MTRF1L; OMA:MTRF1L - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.2 Start 152,987,362 bp [1] End 153,002,709 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A1 Start 5,761,887 bp [2] End 5,773,910 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle endothelial cell buccal mucosa cell pancreatic ductal cell internal globus pallidus tibialis anterior muscle deltoid muscle body of tongue tendon of biceps brachii pericardium Top expressed in tail of embryo genital tubercle otic vesicle Paneth cell medullary collecting duct otolith organ utricle migratory enteric neural crest cell renal corpuscle fossa More reference expression data BioGPS n/a
Gene ontology Molecular function translation release factor activity translation release factor activity, codon specific ribosome binding Cellular component mitochondrial matrix mitochondrion cytoplasm Biological process translational termination protein biosynthesis mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54516 108853 Ensembl ENSG00000112031 ENSMUSG00000019774 UniProt Q9UGC7 Q8BJU9 RefSeq (mRNA) NM_001114184 NM_001301047 NM_001301870 NM_001301871 NM_001301872 NM_019041 NM_175374 RefSeq (protein) NP_001107656 NP_001287976 NP_001288799 NP_001288800 NP_001288801 NP_061914 NP_780583 Location (UCSC) Chr 6: 152.99 – 153 Mb Chr 10: 5.76 – 5.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene. ^[5]

Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM]. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000112031 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019774 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mitochondrial translational release factor 1-like" . Retrieved 2011-09-20.

Further reading

Soleimanpour-Lichaei HR, Kühl I, Gaisne M, Passos JF, Wydro M, Rorbach J, et al. (September 2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG". Molecular Cell. 27 (5): 745–757. doi:10.1016/j.molcel.2007.06.031. PMC   1976341 . PMID   17803939.Nozaki Y, Matsunaga N, Ishizawa T, Ueda T, Takeuchi N (May 2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes to Cells. 13 (5): 429–438. doi: 10.1111/j.1365-2443.2008.01181.x . PMID   18429816. S2CID   21204094.Ishizawa T, Nozaki Y, Ueda T, Takeuchi N (August 2008). "The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC". Biochemical and Biophysical Research Communications. 373 (1): 99–103. Bibcode:2008BBRC..373...99I. doi:10.1016/j.bbrc.2008.05.176. PMID   18541145.Vieira AR, McHenry TG, Daack-Hirsch S, Murray JC, Marazita ML (September 2008). "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts". Genetics in Medicine. 10 (9): 668–674. doi:10.1097/GIM.0b013e3181833793. PMC   2734954 . PMID   18978678.Antonicka H, Ostergaard E, Sasarman F, Weraarpachai W, Wibrand F, Pedersen AM, et al. (July 2010). "Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect". American Journal of Human Genetics. 87 (1): 115–122. doi:10.1016/j.ajhg.2010.06.004. PMC   2896764 . PMID   20598281.