Majdine

Last updated
Majdine
Majdine.svg
Names
IUPAC name
Methyl 11,12-dimethoxy-19α-methyl-2-oxo-20α-formosanan-16-carboxylate
Systematic IUPAC name
Methyl (1′S,3R,4′aS,5′aS,10′aS)-6,7-dimethoxy-1′-methyl-2-oxo-1,2,4′a,5′,5′a,7′,8′,10′a-octahydro-1′H,10′H-spiro[indole-3,6′-pyrano[3,4-f]indolizine]-4′-carboxylate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
  • InChI=1S/C23H28N2O6/c1-12-14-10-25-8-7-23(18(25)9-13(14)15(11-31-12)21(26)30-4)16-5-6-17(28-2)20(29-3)19(16)24-22(23)27/h5-6,11-14,18H,7-10H2,1-4H3,(H,24,27)/t12-,13-,14-,18-,23+/m0/s1
    Key: TTZWEOINXHJHCY-UHJVZONPSA-N
  • InChI=1/C23H28N2O6/c1-12-14-10-25-8-7-23(18(25)9-13(14)15(11-31-12)21(26)30-4)16-5-6-17(28-2)20(29-3)19(16)24-22(23)27/h5-6,11-14,18H,7-10H2,1-4H3,(H,24,27)/t12-,13-,14-,18-,23+/m0/s1
    Key: TTZWEOINXHJHCY-UHJVZONPBK
  • C[C@H]1[C@@H]2CN3CC[C@]4([C@@H]3C[C@@H]2C(=CO1)C(=O)OC)C5=C(C(=C(C=C5)OC)OC)NC4=O
Properties
C23H28N2O6
Molar mass 428.485 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Majdine is an alkaloid isolated from Vinca minor and Vinca herbacea . [2]

Related Research Articles

<span class="mw-page-title-main">Vinča symbols</span> Symbols found upon Vinča culture artifacts

The Vinča symbols or Vinča–Turdaș signs, Old European script, Danube script are a set of untranslated symbols found on Neolithic era artifacts from the Vinča culture and other related "Old European" cultures of Central and Southeastern Europe. Whether this is one of the earliest writing systems or simply symbols of some sort is disputed. They have sometimes been described as an example of proto-writing. The symbols went out of use around 3,500 BC.

<span class="mw-page-title-main">Vinča culture</span> Southeastern European Neolithic archaeological culture

The Vinča culture (ʋîːntʃa), also known as Turdaș culture, Turdaș–Vinča culture or Vinča-Turdaș culture, is a Neolithic archaeological culture of Southeast Europe, dated to the period 5400–4500 BC. Named for its type site, Vinča-Belo Brdo, a large tell settlement discovered by Serbian archaeologist Miloje Vasić in 1908, it represents the material remains of a prehistoric society mainly distinguished by its settlement pattern and ritual behaviour.

Periwinkle may refer to:

<i>Catharanthus</i> Genus of flowering plants

Catharanthus is a genus of flowering plants in the family Apocynaceae. Like the genus Vinca, they are known commonly as periwinkles. There are eight known species. Seven are endemic to Madagascar, though one, C. roseus, is widely naturalized around the world. The eighth species, C. pusillus, is native to India and Sri Lanka. The name Catharanthus comes from the Greek for "pure flower".

<i>Erythrina herbacea</i> Species of legume

Erythrina herbacea, commonly known as the coral bean, Cherokee bean, Mamou plant in South Louisiana, red cardinal or cardinal spear, is a flowering shrub or small tree found throughout the southeastern United States and northeastern Mexico; it has also been reported from parts of Central America and, as an introduced species, from Pakistan. Various other systematic names have been used for this plant in the past, including Erythrina arborea, Erythrina hederifolia, Erythrina humilis, Erythrina rubicunda, Corallodendron herbaceum and Xyphanthus hederifolius.

<i>Salix herbacea</i> Species of herb

Salix herbacea, the dwarf willow, least willow or snowbed willow, is a species of tiny creeping willow adapted to survive in harsh arctic and subarctic environments. Distributed widely in alpine and arctic environments around the North Atlantic Ocean, it is one of the smallest of woody plants.

<i>Vinca</i> Genus of flowering plants

Vinca is a genus of flowering plants in the family Apocynaceae, native to Europe, northwest Africa and southwest Asia. The English name periwinkle is shared with the related genus Catharanthus.

<i>Vinca minor</i> Species of flowering plant in the dogbane family

Vinca minor is a species of flowering plant in the dogbane family, native to central and southern Europe, from Portugal and France north to the Netherlands and the Baltic States, east to the Caucasus, and also southwestern Asia in Turkey. Other vernacular names used in cultivation include small periwinkle, common periwinkle, and sometimes in the United States, myrtle or creeping myrtle.

<i>Vinca</i> alkaloid

Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus and other vinca plants. They block beta-tubulin polymerization in a dividing cell.

<span class="mw-page-title-main">Vindesine</span> Chemical compound

Vindesine, also termed Eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant Catharanthus roseus. Like the natural and semisynthetic vinca alkaloids derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. By inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.

<i>Vinca major</i> Species of vine

Vinca major, with the common names bigleaf periwinkle, large periwinkle, greater periwinkle and blue periwinkle, is a species of flowering plant in the family Apocynaceae, native to the western Mediterranean. Growing to 25 cm (10 in) tall and spreading indefinitely, it is an evergreen perennial, frequently used in cultivation as groundcover.

<i>Vinca herbacea</i> Species of plant

Vinca herbacea, with common name herbaceous periwinkle, is a flowering plant native to eastern and southeastern Europe, from Austria south to Greece, and east to the Crimea, and also in northern Western Asia, in the Caucasus and Alborz mountains.

<span class="mw-page-title-main">Vinča-Belo Brdo</span> Archaeological type site in Serbia

Vinča-Belo Brdo is an archaeological site in Vinča, a suburb of Belgrade, Serbia. The tell of Belo Brdo is almost entirely made up of the remains of human settlement, and was occupied several times from the Early Neolithic through to the Middle Ages. The most substantial archaeological deposits are from the Neolithic-Chalcolithic Vinča culture, of which Vinča-Belo Brdo is the type site.

<span class="mw-page-title-main">Ludaš Lake</span> Lake in Subotica, Serbia

Ludaš or Ludoš Lake is a shallow lake in the province of Vojvodina in northern Serbia, near the city of Subotica. It is a special natural preserve and, since 1977, designated as a swamp area of international significance by the Ramsar Convention. The name of the lake stems from Hungarian "ludas", meaning goose.

<i>Smilax herbacea</i> Species of flowering plant

Smilax herbacea, the smooth carrionflower or smooth herbaceous greenbrier, is a plant in the catbriar family. It is native to eastern Canada and the eastern United States. Its preferred natural habitat is rich forests, and riparian thicket and meadows.

<span class="mw-page-title-main">Vinça</span> Commune in Occitania, France

Vinça is a commune in the Pyrénées-Orientales department in southern France.

This article describes flora of Turkey that belong to the flowering plant family Apocynaceae.

<span class="mw-page-title-main">Vinča Nuclear Institute</span> Nuclear physics research organization in Serbia

The Vinča Institute of Nuclear Sciences is a nuclear physics research institution near Belgrade, Serbia. Since its founding, the institute has also conducted research in the fields in physics, chemistry and biology. The scholarly institute is part of the University of Belgrade.

<i>Tetraneuris herbacea</i> Species of flowering plant

Tetraneuris herbacea is a rare species of flowering plant in the aster family known by the common names eastern fournerved daisy, lakeside daisy, fournerved starflower, and Manitoulin gold. It is native to and endemic to the Great Lakes region in North America, where it is present in Ontario, Ohio, Michigan, and Illinois. It is threatened by habitat destruction and degradation by several forces, including limestone quarrying, recreational activity, fire suppression, and construction. It is a federally listed threatened species of the United States and of Canada.

The Vinca massacre was a massacre carried out near Fivizzano, Tuscany, by the German 16th SS Panzergrenadier Division from 24 to 27 August 1944 in which 162 Italian civilians were killed.

References

  1. "Majdine Mass Spectrum". massbank.eu.
  2. Gülçin, I.; Beydemir, S.; Topal, F.; Gagua, N.; Bakuridze, A.; Bayram, R.; Gepdiremen, A. (2012). "Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit". Journal of Enzyme Inhibition and Medicinal Chemistry. 27 (4): 587–594. doi:10.3109/14756366.2011.604318. PMID   21883037.