Malotilate

Malotilate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	none;
Legal status
Legal status	Experimental(?);
Identifiers
	IUPAC name diisopropyl 1,3-dithiol-2-ylidenemalonate;
CAS Number	59937-28-9 ;
PubChem CID	4006 ;
ChemSpider	3866 ;
UNII	RV59PND975 ;
ChEMBL	ChEMBL1697754 ;
CompTox Dashboard (EPA)	DTXSID7046463 ;
ECHA InfoCard	100.056.334
Chemical and physical data
Formula	C12H16O4S2
Molar mass	288.38 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C;
	InChI InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3 ; Key:YPIQVCUJEKAZCP-UHFFFAOYSA-N ;
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Last updated January 11, 2026

Malotilate (INN) is a drug that has been used in studies for the treatment of liver disease. It has been shown to facilitate liver regeneration in rats.^[1]

References

↑ Niwano Y, Katoh M, Uchida M, Sugimoto T (1986). "Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats". Japanese Journal of Pharmacology. 40 (3): 411–415. doi: 10.1254/jjp.40.411 . PMID 2423727.

Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). "Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis". Eur. J. Clin. Pharmacol. 30 (4): 407–16. doi:10.1007/BF00607952. PMID 3743616. S2CID 19898827.
Siegers CP, Pauli V, Korb G, Younes M (August 1986). "Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis". Agents Actions. 18 (5–6): 600–3. doi:10.1007/BF01964970. PMID 3766314. S2CID 3213262.
Younes M, Siegers CP (May 1985). "Effect of malotilate on paracetamol-induced hepatotoxicity". Toxicol. Lett. 25 (2): 143–6. doi:10.1016/0378-4274(85)90074-8. PMID 4002245.

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[1] Niwano Y, Katoh M, Uchida M, Sugimoto T (1986). "Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats". Japanese Journal of Pharmacology. 40 (3): 411–415. doi: 10.1254/jjp.40.411 . PMID 2423727.

[1]

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	none
Legal status
Legal status	Experimental(?)
Identifiers
IUPAC name diisopropyl 1,3-dithiol-2-ylidenemalonate
CAS Number	59937-28-9 ^N
PubChem CID	4006
ChemSpider	3866 ^N
UNII	RV59PND975
ChEMBL	ChEMBL1697754 ^N
CompTox Dashboard (EPA)	DTXSID7046463
ECHA InfoCard	100.056.334
Chemical and physical data
Formula	C₁₂H₁₆O₄S₂
Molar mass	288.38 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C
InChI InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3^N Key:YPIQVCUJEKAZCP-UHFFFAOYSA-N^N
^NY (what is this?) (verify)