Metabolically healthy obesity

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Metabolically healthy obesity (MHO) is a disputed research concept primarily used in epidemiological studies to describe individuals with body mass index (BMI) values in the obese range who do not exhibit metabolic complications commonly associated with obesity. [1] It is not recognized as a distinct clinical diagnosis, and being classified as MHO does not imply that an individual is medically unhealthy or requires treatment.

Contents

Characteristics

No universally accepted criteria exist to define putative MHO, [1] but definitions generally require the patient to be obese and to lack metabolic abnormalities such as dyslipidemia, impaired glucose tolerance, [2] or metabolic syndrome. [3]

MHO individuals display less visceral adipose tissue, smaller adipocytes, and a reduced inflammatory profile relative to metabolically unhealthy obese individuals. [3] [4] [5] As a result, it has been argued that cardiometabolic risk might not improve significantly as a result of weight loss interventions. [6]

Epidemiology

Prevalence estimates of MHO have varied from 6 to 75 percent, [7] and it has been argued that between 10 and 25 percent of obese individuals are metabolically healthy. [8] One study found that 47.9% of obese people had MHO, while another found that 11% did. [3] It seems to be more prevalent in women than men, and its prevalence decreases with age. [9] [10]

Outcomes

Some research suggests that metabolically healthy obese individuals are at an increased risk of several adverse outcomes when compared to individuals of a normal weight, including type 2 diabetes, [11] depressive symptoms, [12] and cardiovascular events. [13] [14] Other research also suggests that although MHO individuals display a favorable metabolic profile, this does not necessarily translate into a decrease in mortality. [15] Research to date has produced conflicting results with respect to cardiovascular disease and mortality. [16] MHO individuals are at a higher risk of cardiovascular disease compared to metabolically healthy non-obese individuals, but they are also at a lower risk thereof than individuals who are both unhealthy and obese. [17] [18] A 2016 meta-analysis found that MHO individuals were not at an increased risk of all-cause mortality (but were at an increased risk of cardiovascular events). [19] The relatively low risk of cardiovascular disease among people with MHO relative to metabolically unhealthy obese people has been attributed to differences in white adipose tissue function between the two groups. [20]

See also

References

  1. 1 2 Stefan, Norbert; Häring, Hans-Ulrich; Hu, Frank B; Schulze, Matthias B (October 2013). "Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications". The Lancet Diabetes & Endocrinology. 1 (2): 152–162. doi:10.1016/S2213-8587(13)70062-7. PMID   24622321.
  2. ↑ Puri, Rishi (June 2014). "Is it Finally Time to Dispel the Concept of Metabolically-Healthy Obesity?". Journal of the American College of Cardiology. 63 (24): 2687–2688. doi: 10.1016/j.jacc.2014.03.043 . PMID   24794116.
  3. 1 2 3 Denis, Gerald V.; Obin, Martin S. (February 2013). "'Metabolically healthy obesity': Origins and implications". Molecular Aspects of Medicine. 34 (1): 59–70. doi:10.1016/j.mam.2012.10.004. PMC   3583231 . PMID   23068072.
  4. ↑ Navarro, Estanislau; Funtikova, Anna N.; Fíto, Montserrat; Schröder, Helmut (November 2014). "Can Metabolically Healthy Obesity be explained by diet, genetics and inflammation?". Molecular Nutrition & Food Research. 59 (1): 75–93. doi:10.1002/mnfr.201400521. PMID   25418549.
  5. ↑ Muñoz-Garach, Araceli; Cornejo-Pareja, Isabel; Tinahones, Francisco J. (1 June 2016). "Does Metabolically Healthy Obesity Exist?". Nutrients. 8 (6): 320. doi: 10.3390/nu8060320 . ISSN   2072-6643. PMC   4924161 . PMID   27258304.
  6. ↑ Bluher, M. (10 July 2014). "MECHANISMS IN ENDOCRINOLOGY: Are metabolically healthy obese individuals really healthy?". European Journal of Endocrinology. 171 (6): R209 –R219. doi: 10.1530/EJE-14-0540 . PMID   25012199.
  7. ↑ Rey-López, JP; de Rezende, LF; Pastor-Valero, M; Tess, BH (October 2014). "The prevalence of metabolically healthy obesity: a systematic review and critical evaluation of the definitions used". Obesity Reviews. 15 (10): 781–90. doi:10.1111/obr.12198. PMID   25040597. S2CID   825441.
  8. ↑ Blüher, Matthias (February 2010). "The distinction of metabolically 'healthy' from 'unhealthy' obese individuals". Current Opinion in Lipidology. 21 (1): 38–43. doi:10.1097/MOL.0b013e3283346ccc. PMID   19915462. S2CID   2054728.
  9. ↑ Blüher, Susann; Schwarz, Peter (September 2014). "Metabolically healthy obesity from childhood to adulthood — Does weight status alone matter?". Metabolism. 63 (9): 1084–1092. doi:10.1016/j.metabol.2014.06.009. PMID   25038727.
  10. ↑ van Vliet-Ostaptchouk, Jana V; Nuotio, Marja-Liisa; Slagter, Sandra N; Doiron, Dany; Fischer, Krista; Foco, Luisa; Gaye, Amadou; Gögele, Martin; Heier, Margit; Hiekkalinna, Tero; Joensuu, Anni; Newby, Christopher; Pang, Chao; Partinen, Eemil; Reischl, Eva; Schwienbacher, Christine; Tammesoo, Mari-Liis; Swertz, Morris A; Burton, Paul; Ferretti, Vincent; Fortier, Isabel; Giepmans, Lisette; Harris, Jennifer R; Hillege, Hans L; Holmen, Jostein; Jula, Antti; Kootstra-Ros, Jenny E; Kvaløy, Kirsti; Holmen, Turid; Männistö, Satu; Metspalu, Andres; Midthjell, Kristian; Murtagh, Madeleine J; Peters, Annette; Pramstaller, Peter P; Saaristo, Timo; Salomaa, Veikko; Stolk, Ronald P; Uusitupa, Matti; van der Harst, Pim; van der Klauw, Melanie M; Waldenberger, Melanie; Perola, Markus; Wolffenbuttel, Bruce HR (2014). "The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies". BMC Endocrine Disorders. 14 (1): 9. doi: 10.1186/1472-6823-14-9 . PMC   3923238 . PMID   24484869.
  11. ↑ Bell, JA; Kivimaki, M; Hamer, M (June 2014). "Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies" (PDF). Obesity Reviews. 15 (6): 504–15. doi:10.1111/obr.12157. PMC   4309497 . PMID   24661566.
  12. ↑ Jokela, M; Hamer, M; Singh-Manoux, A; Batty, G D; Kivimäki, M (3 December 2013). "Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies". Molecular Psychiatry. 19 (8): 910–914. doi:10.1038/mp.2013.162. PMC   4921125 . PMID   24296976.
  13. ↑ Kramer, Caroline K.; Zinman, Bernard; Retnakaran, Ravi (3 December 2013). "Are Metabolically Healthy Overweight and Obesity Benign Conditions?". Annals of Internal Medicine. 159 (11): 758–69. doi:10.7326/0003-4819-159-11-201312030-00008. PMID   24297192. S2CID   9431877.
  14. ↑ Eckel, Nathalie; Meidtner, Karina; Kalle-Uhlmann, Tamara; Stefan, Norbert; Schulze, Matthias B (2016). "Metabolically healthy obesity and cardiovascular events: A systematic review and meta-analysis". European Journal of Preventive Cardiology. 23 (9): 956–966. doi:10.1177/2047487315623884. PMID   26701871. S2CID   6085134.
  15. ↑ Primeau, V; Coderre, L; Karelis, A D; Brochu, M; Lavoie, M-E; Messier, V; Sladek, R; Rabasa-Lhoret, R (26 October 2010). "Characterizing the profile of obese patients who are metabolically healthy". International Journal of Obesity. 35 (7): 971–981. doi:10.1038/ijo.2010.216. PMID   20975726.
  16. ↑ Phillips, Catherine M. (9 August 2013). "Metabolically healthy obesity: Definitions, determinants and clinical implications". Reviews in Endocrine and Metabolic Disorders. 14 (3): 219–227. doi:10.1007/s11154-013-9252-x. PMID   23928851. S2CID   489228.
  17. ↑ Roberson, Lara L; Aneni, Ehimen C; Maziak, Wasim; Agatston, Arthur; Feldman, Theodore; Rouseff, Maribeth; Tran, Thinh; Blaha, Michael J; Santos, Raul D; Sposito, Andrei; Al-Mallah, Mouaz H; Blankstein, Ron; Budoff, Matthew J; Nasir, Khurram (2014). "Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review". BMC Public Health. 14 (1): 14. doi: 10.1186/1471-2458-14-14 . PMC   3890499 . PMID   24400816.
  18. ↑ Fan, Jingyao; Song, Yiqing; Chen, Yu; Hui, Rutai; Zhang, Weili (October 2013). "Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: A meta-analysis of prospective cohort studies". International Journal of Cardiology. 168 (5): 4761–4768. doi:10.1016/j.ijcard.2013.07.230. PMID   23972953.
  19. ↑ Zheng, R; Zhou, D; Zhu, Y (28 April 2016). "The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and meta-analysis". Journal of Epidemiology and Community Health. 70 (10): 1024–1031. doi:10.1136/jech-2015-206948. PMID   27126492. S2CID   21145367.
  20. ↑ Badoud, F; Perreault, M; Zulyniak, MA; Mutch, DM (19 November 2014). "Molecular insights into the role of white adipose tissue in metabolically unhealthy normal weight and metabolically healthy obese individuals". FASEB Journal. 29 (3): 748–758. doi: 10.1096/fj.14-263913 . PMID   25411437.

https://www.scientificamerican.com/article/people-who-are-fat-and-healthy-may-hold-keys-to-understanding-obesity/

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