Metallothionein 1A

MT1A
Identifiers
Aliases	MT1A , MT1, MT1S, MTC, Metallothionein 1A, MT-1A, MT-IA
External IDs	OMIM: 156350; GeneCards: MT1A; OMA:MT1A - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q13 Start 56,638,666 bp [1] End 56,640,087 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial membrane middle frontal gyrus epithelium of bronchus metanephric glomerulus spinal ganglia thalamus trachea paraflocculus of cerebellum frontal pole vastus lateralis muscle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding metal ion binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol nucleus Biological process response to metal ion negative regulation of growth cellular response to cadmium ion cellular response to zinc ion cellular zinc ion homeostasis detoxification of copper ion cellular response to copper ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4489 n/a Ensembl ENSG00000205362 n/a UniProt P04731 n/a RefSeq (mRNA) NM_005946 n/a RefSeq (protein) NP_005937 n/a Location (UCSC) Chr 16: 56.64 – 56.64 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Metallothionein-1A is a protein that in humans is encoded by the MT1A gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000205362 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proceedings of the National Academy of Sciences of the United States of America . 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC   391732 . PMID   6089206.
4. Richards RI, Heguy A, Karin M (Jun 1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids". Cell . 37 (1): 263–72. doi: 10.1016/0092-8674(84)90322-2 . PMID   6327055.
5. "Entrez Gene: MT1A metallothionein 1A".

Further reading

• Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: an overview". World Journal of Gastroenterology . 13 (7): 993–6. doi: 10.3748/wjg.v13.i7.993 . PMC   4146885 . PMID   17373731.
• Sutherland GR, Baker E, Callen DF, et al. (1990). "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia". Genomics . 6 (1): 144–8. doi:10.1016/0888-7543(90)90459-8. PMID   2303255.
• Grider A, Bailey LB, Cousins RJ (1990). "Erythrocyte metallothionein as an index of zinc status in humans". Proceedings of the National Academy of Sciences of the United States of America . 87 (4): 1259–62. Bibcode:1990PNAS...87.1259G. doi: 10.1073/pnas.87.4.1259 . PMC   53453 . PMID   2304897.
• Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia". Nature . 313 (6004): 709–11. Bibcode:1985Natur.313..709L. doi:10.1038/313709a0. PMID   3856101. S2CID   4321473.
• Hunziker PE, Kägi JH (1985). "Isolation and characterization of six human hepatic isometallothioneins". Biochemical Journal . 231 (2): 375–82. doi:10.1042/bj2310375. PMC   1152756 . PMID   4062903.
• Armitage IM, Otvos JD, Briggs RW, Boulanger Y (1983). "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR". Federation Proceedings . 41 (13): 2974–80. PMID   7140998.
• Akintola DF, Sampson B, Fleck A (1995). "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine". The Journal of Laboratory and Clinical Medicine . 126 (2): 119–27. PMID   7543551.
• Davis SR, McMahon RJ, Cousins RJ (1998). "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression". Journal of Nutrition . 128 (5): 825–31. doi: 10.1093/jn/128.5.825 . PMID   9566988.
• Simpkins C, Lloyd T, Li S, Balderman S (1998). "Metallothionein-induced increase in mitochondrial inner membrane permeability". Journal of Surgical Research . 75 (1): 30–4. doi:10.1006/jsre.1997.5241. PMID   9614853.
• Lau JC, Cherian MG (1999). "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice". Biochemistry and Cell Biology . 76 (4): 615–23. doi:10.1139/bcb-76-4-615. PMID   10099782.
• Levadoux M, Mahon C, Beattie JH, et al. (2000). "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton". Journal of Biological Chemistry . 274 (49): 34961–6. doi: 10.1074/jbc.274.49.34961 . PMID   10574972.
• Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". The Prostate . 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID   10754528. S2CID   8768274.
• Campagne MV, Thibodeaux H, van Bruggen N, et al. (2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion". The Journal of Neuroscience . 20 (14): 5200–7. doi:10.1523/JNEUROSCI.20-14-05200.2000. PMC   6772313 . PMID   10884303.
• Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". European Journal of Biochemistry . 268 (3): 849–56. doi: 10.1046/j.1432-1327.2001.01947.x . PMID   11168427.
• Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM (2001). "Influence of metallothionein-1 localization on its function". Biochemical Journal . 355 (Pt 2): 473–9. doi:10.1042/0264-6021:3550473. PMC   1221760 . PMID   11284736.
• Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins". Analytical and Bioanalytical Chemistry . 372 (3): 412–7. doi:10.1007/s00216-001-1187-5. PMID   11939525. S2CID   21611530.
• Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH". Journal of Chromatography B . 779 (2): 211–9. doi:10.1016/S1570-0232(02)00375-6. PMID   12361735.