Metallothionein 1A

MT1A
Identifiers
Aliases	MT1A , MT1, MT1S, MTC, Metallothionein 1A, MT-1A, MT-IA
External IDs	OMIM: 156350 GeneCards: MT1A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,640,087 bp
RNA expression pattern
	Top expressed in
	synovial membrane; ; middle frontal gyrus; ; metanephric glomerulus; ; spinal ganglia; ; trachea; ; frontal pole; ; vastus lateralis muscle; ; Brodmann area 10; ; cerebellar vermis; ; left uterine tube;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding ; protein binding ; metal ion binding ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ; cytosol ; nucleus ;
Biological process	response to metal ion ; negative regulation of growth ; cellular response to cadmium ion ; cellular response to zinc ion ; cellular zinc ion homeostasis ; detoxification of copper ion ; cellular response to copper ion ;
	Sources:Amigo / QuickGO
Orthologs
	4489
	n/a
	ENSG00000205362
	n/a
	P04731
	n/a
	NM_005946
	n/a
	NP_005937
	n/a
	Wikidata
View/Edit Human

Last updated September 07, 2023

Metallothionein-1A is a protein that in humans is encoded by the MT1A gene.^[3]^[4]^[5]

Related Research Articles

Metallothionein (MT) is a family of cysteine-rich, low molecular weight proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological and xenobiotic heavy metals through the thiol group of its cysteine residues, which represent nearly 30% of its constituent amino acid residues.

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.

Metallothionein-3 is a protein that in humans is encoded by the MT3 gene. It is a 68-amino acid peptide that is abnormally under-expressed in the brains of patients with Alzheimer's disease. Metallothionein-3 is a member of the metallothionein family of proteins.

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.

Metallothionein-1F is a protein that in humans is encoded by the MT1F gene.

Metallothionein-1E is a protein that in humans is encoded by the MT1E gene.

Metallothionein 1X, also known as MT1X, is a protein which in humans is encoded by the gene.

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.

Metallothionein-1G is a protein that in humans is encoded by the MT1G gene.

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.

Metallothionein-1H is a protein that in humans is encoded by the MT1H gene.

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.

Zinc finger protein 655 is a protein that in humans is encoded by the ZNF655 gene.

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.

Metallothionein-1B is a protein that in humans is encoded by the MT1B gene.

Metallothionein-1M is a protein that in humans is encoded by the MT1M gene.

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000205362 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proceedings of the National Academy of Sciences of the United States of America . 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC 391732 . PMID 6089206.
↑ Richards RI, Heguy A, Karin M (Jun 1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids". Cell . 37 (1): 263–72. doi: 10.1016/0092-8674(84)90322-2 . PMID 6327055.
↑ "Entrez Gene: MT1A metallothionein 1A".

Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: an overview". World Journal of Gastroenterology . 13 (7): 993–6. doi: 10.3748/wjg.v13.i7.993 . PMC 4146885 . PMID 17373731.
Sutherland GR, Baker E, Callen DF, et al. (1990). "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia". Genomics . 6 (1): 144–8. doi:10.1016/0888-7543(90)90459-8. PMID 2303255.
Grider A, Bailey LB, Cousins RJ (1990). "Erythrocyte metallothionein as an index of zinc status in humans". Proceedings of the National Academy of Sciences of the United States of America . 87 (4): 1259–62. Bibcode:1990PNAS...87.1259G. doi: 10.1073/pnas.87.4.1259 . PMC 53453 . PMID 2304897.
Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia". Nature . 313 (6004): 709–11. Bibcode:1985Natur.313..709L. doi:10.1038/313709a0. PMID 3856101. S2CID 4321473.
Hunziker PE, Kägi JH (1985). "Isolation and characterization of six human hepatic isometallothioneins". Biochemical Journal . 231 (2): 375–82. doi:10.1042/bj2310375. PMC 1152756 . PMID 4062903.
Armitage IM, Otvos JD, Briggs RW, Boulanger Y (1983). "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR". Federation Proceedings . 41 (13): 2974–80. PMID 7140998.
Akintola DF, Sampson B, Fleck A (1995). "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine". The Journal of Laboratory and Clinical Medicine . 126 (2): 119–27. PMID 7543551.
Davis SR, McMahon RJ, Cousins RJ (1998). "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression". Journal of Nutrition . 128 (5): 825–31. doi: 10.1093/jn/128.5.825 . PMID 9566988.
Simpkins C, Lloyd T, Li S, Balderman S (1998). "Metallothionein-induced increase in mitochondrial inner membrane permeability". Journal of Surgical Research . 75 (1): 30–4. doi:10.1006/jsre.1997.5241. PMID 9614853.
Lau JC, Cherian MG (1999). "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice". Biochemistry and Cell Biology . 76 (4): 615–23. doi:10.1139/bcb-76-4-615. PMID 10099782.
Levadoux M, Mahon C, Beattie JH, et al. (2000). "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton". Journal of Biological Chemistry . 274 (49): 34961–6. doi: 10.1074/jbc.274.49.34961 . PMID 10574972.
Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". The Prostate . 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.
Campagne MV, Thibodeaux H, van Bruggen N, et al. (2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion". The Journal of Neuroscience . 20 (14): 5200–7. doi:10.1523/JNEUROSCI.20-14-05200.2000. PMC 6772313 . PMID 10884303.
Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". European Journal of Biochemistry . 268 (3): 849–56. doi: 10.1046/j.1432-1327.2001.01947.x . PMID 11168427.
Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM (2001). "Influence of metallothionein-1 localization on its function". Biochemical Journal . 355 (Pt 2): 473–9. doi:10.1042/0264-6021:3550473. PMC 1221760 . PMID 11284736.
Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins". Analytical and Bioanalytical Chemistry . 372 (3): 412–7. doi:10.1007/s00216-001-1187-5. PMID 11939525. S2CID 21611530.
Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH". Journal of Chromatography B . 779 (2): 211–9. doi:10.1016/S1570-0232(02)00375-6. PMID 12361735.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000205362 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6089206-3] Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proceedings of the National Academy of Sciences of the United States of America . 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC 391732 . PMID 6089206.

[pmid6327055-4] Richards RI, Heguy A, Karin M (Jun 1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids". Cell . 37 (1): 263–72. doi: 10.1016/0092-8674(84)90322-2 . PMID 6327055.

[entrez-5] "Entrez Gene: MT1A metallothionein 1A".

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Metallothionein 1A

Related Research Articles

References

Further reading