Route 141, also known as Woods Mill Road in parts of St. Louis County, is a state highway located in the western St. Louis metropolitan area. Its northern terminus is at Route 370 in Bridgeton; its southern terminus is at U.S. Route 61/U.S. Route 67 in Arnold, in Jefferson County. The northern stretches of the highway are often referred to as the Maryland Heights Expressway or Earth City Expressway.
Route 215 is a highway in southern Missouri. Its northern terminus is at Route 39 south of Stockton; its southern terminus is at U.S. Route 65 between Buffalo and Springfield. Except for a short section which overlaps Route 13, it is a two-lane highway its entire length. It was originally a set of supplemental routes. In the early 2000s, US 65 was realigned and the southern terminus was extended about one mile (1.6 km) east opposite the western terminus of Route O. The highway runs more east–west than north–south, but is marked as a north–south highway.
Route 265 is a highway in southwestern Missouri. Its northern terminus is at Interstate 44 in Mount Vernon; its southern terminus is at U.S. Route 65 south of Branson. Much of the highway is concurrent with other routes. It is also known as the Ozark Mountain Parkway.
Route 30 is a highway in eastern Missouri, United States. Its eastern terminus is at the Interstate 55/Interstate 44 junction in St. Louis. Its western terminus is at Interstate 44 in St. Clair. In St. Louis, the section between Interstate 44 and Route 366 is part of historic U.S. Route 66 and is marked as such. In the St. Louis area, it is known as Gravois Avenue or Gravois Road. Further south, Gravois Rd. is used to mark the old section of the highway where the newer, divided highway rerouted Highway 30.
Route 83 is a state highway in western Missouri. Its northern terminus is at U.S. Route 65/Route 7 at Warsaw; its southern terminus is at Route 13 in Bolivar. It is a two-lane highway its entire length.
Route 21 is a highway in eastern Missouri. Its northern terminus is at Route 30 in Affton. Its southern terminus is at the Arkansas state line. In the St. Louis area, it is known as Tesson Ferry Road, which was named after the 19th century proprietor of the ferry across the Meramec River.
Route 240 is a highway in the central part of Missouri. Its eastern terminus is at U.S. Route 40 about two miles (3 km) west of Columbia; its western terminus is at U.S. Route 65 in Marshall. Spur Route 240 connects the road with Rocheport.
Route 112 is a highway in southwestern Missouri. Both termini are with Route 37. The northern terminus is in Cassville and the southern terminus is in Seligman. There are no other towns on the route, but Roaring River State Park is located about ten miles (16 km) south of Cassville on the route.
Route 34 is a highway in southeastern Missouri. Its eastern terminus is at the Illinois state line on the Mississippi River at Cape Girardeau where it overlaps Route 74. Its western terminus is at U.S. Route 60 near Van Buren. The road continues into Illinois as Illinois Route 146.
Route 105 is a highway in Mississippi County, Missouri. Its northern terminus is at Interstate 57/U.S. Route 60 in Charleston; its southern terminus is at Route 80 in East Prairie. Other than the two termini, no other towns are on the route.
Route 58 is a highway in western Missouri. Its eastern terminus is at U.S. Route 50 west of Warrensburg; its western terminus is at Route D west of Belton, Missouri. It is one of only a very few highways to end at a state supplemental route.
Route 109 is a state highway in St. Louis County, Missouri and Jefferson County, Missouri. Its northern terminus is at Wild Horse Creek Road in Chesterfield; its southern terminus is at Routes W and FF in Jefferson County. The road continues north, curves around Spirit of St. Louis Airport and connects with Chesterfield Airport Road, providing a "backway" to the Chesterfield area.
Route 111 is a highway in northwestern Missouri. Its northern terminus is at U.S. Route 136 in Rock Port; its southern terminus is at U.S. Route 59 in Oregon. The entire length of Route 111 is part of the Lewis and Clark Trail.
Route 89 is a highway in central Missouri. Its northern terminus is at Route 100 in Chamois; its southern terminus is at Route 28 in Belle. A short spur of Highway 89 connects with east U.S. Route 50 east of Linn.
Route 49 is a highway in eastern Missouri. Its northern terminus is at Route 19 in Cherryville, and its southern terminus is at U.S. Route 67 five miles (8 km) east of Williamsville.
Route 106 is a highway in the southern part of the US State of Missouri. Its eastern terminus is at Route 21 at Ellington; its western terminus is at Route 17 in Summersville. Route 106 runs through the eastern, mountainous Ozarks and through two sections of the Ozark National Scenic Riverways.
Route 154 is a highway in northeastern Missouri. Its eastern terminus is at U.S. Route 54 north of Vandalia; its western terminus is at U.S. Route 24) west of Paris, where Business US 24 also has its western terminus. Route 154 passes through Mark Twain State Park and over Mark Twain Lake.
Route 119 is a highway in Dent County. Its northern terminus is at Route 32 southwest of Salem; its southern terminus is at Montauk State Park. There are no towns on the highway.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
Route 8 in Potosi 
US 50 in Beaufort 
Route 100 north of Campbellton 
