Interstate 72 (I-72) is an Interstate Highway in the midwestern United States. Its western terminus is in Hannibal, Missouri, at an intersection with U.S. Route 61 (US 61); its eastern terminus is at Country Fair Drive in Champaign, Illinois. The route runs through the major cities of Decatur, Illinois, and Springfield, Illinois. In 2006, the Illinois General Assembly dedicated all of I-72 as Purple Heart Memorial Highway. The stretch between Springfield and Decatur is also called Penny Severns Memorial Expressway, and the section between mile 35 and the Mississippi River is known as the Free Frank McWorter Historic Highway.
U.S. Route 400 is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada, Colorado, at an intersection with US 385. The highway's eastern terminus is southwest of Joplin, Missouri, near Loma Linda, at an interchange with Interstate 44, with which it shares with US 166. It originally ended in Garden City, Kansas; in 1996 it was extended to its current western terminus.
Interstate 435 (I-435) is an Interstate Highway beltway that encircles much of the Kansas City metropolitan area within the states of Kansas and Missouri in the United States.
U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.
U.S. Route 56 is an east–west United States highway that runs for approximately 640 miles (1,030 km) in the Midwestern United States. US 56's western terminus is at Interstate 25 Business, US 412 and New Mexico State Road 21 in Springer, New Mexico and the highway's eastern terminus is at US 71 in Kansas City, Missouri. Much of it follows the Santa Fe Trail.
U.S. Highway 159 (US 159) is a 83.6-mile-long (134.5 km) auxiliary route of US 59. It travels from Nortonville, Kansas at US 59 to New Point, Missouri, also at US 59. The highway permits through traffic on US 59 to bypass the cities of Atchison, Kansas and Saint Joseph, Missouri, traveling instead through Falls City, Nebraska and Hiawatha, Kansas.
Route 96 is a state highway that travels from Route 171 near Carl Junction, in Jasper County, to Interstate 44 (I-44) in Halltown, in Lawrence County. A large section of the highway between Carthage and Halltown served as part of U.S. Route 66 (US 66) and is currently marked as Historic Route 66.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 171 is a short highway in southwestern Missouri. Its northern terminus is at the Kansas state line where it continues as K-171 near Opolis, Kansas. Its southern terminus is at the junction of Interstate 49/U.S. Route 71, Route 96 and Route 571 in Carthage. The last ten southbound miles are concurrent with Business I-49.
Route 371 is a highway in western Missouri. Its southern terminus is at Route 273 north of Tracy. Its northern terminus is at Route 752 in St. Joseph. It is a former alignment of U.S. Route 71 (US 71).
Route 350 is a highway in the Kansas City, Missouri, area. Its eastern terminus is at the Interstate 470/U.S. Route 50 (I-470/US 50) interchange in Lee's Summit; its western terminus is at I-435 in Kansas City. Along the northern terminus, it fades into Blue Parkway and part of the route is an old alignment of US 50. Notable development along Route 350, particularly in and nearing Raytown, occurred in the late 1970s into the 1980s. However, much of this area now shows its age and the changing socioeconomic makeup of the area, with retail chains falling into disrepair or closing.
K-171 is a state highway in the southeastern part of the U.S. state of Kansas. The 4.890-mile (7.870 km) highway mostly lies on the Crawford County/Cherokee County line except for the easternmost 0.4 miles (0.64 km) of the highway when it is entirely in Cherokee County. Its western terminus is at the intersection of U.S. Route 69 (US-69), US-160 and US-400 south of Pittsburg and its eastern terminus is a continuation as Missouri Route 171 at the Missouri state line near Opolis. K-171's current route was established on May 14, 2003, and the routing has not changed since.
Route 2 is a highway in western Missouri. Its western terminus is at the Kansas state line about three miles (4.8 km) southwest of West Line; it continues into Kansas as K-68. Its eastern terminus is at Route 52 in Windsor.
Route 9 is a highway in the Kansas City, Missouri area. Its northern terminus is at Interstate 29/U.S. Route 71 in Kansas City North; its southern terminus is at Interstate 35/Interstate 70/U.S. Route 24/U.S. Route 40 in downtown Kansas City. Even though both termini are in Kansas City, it passes through other towns and cities. It is carried across the Missouri River by the Heart of America Bridge between downtown Kansas City, Missouri and North Kansas City, Missouri. In North Kansas City, the highway serves as a main thoroughfare, Burlington Street.
Route 45 is a highway in northwest Missouri, US in Buchanan County and Platte County which is largely in the bottom land alongside the Missouri River.
Route 82 is a highway in southwest Missouri. Its eastern terminus is at Route 83 in northwest Hickory County; its western terminus is at U.S. Route 54 in El Dorado Springs.
U.S. Route 169 (US-169) is a major north–south U.S. Highway that runs from US-64 in Tulsa, Oklahoma, to US-53 near Virginia, Minnesota. In Kansas, the highway is a main north–south route that runs through the eastern end of the state from the Oklahoma border to Missouri border. Along the way US-169 intersects several major highways including US-400 by Cherryvale, US-54 by Iola, overlaps US-59 south of Garnett, overlaps I-35 from Olathe to Merriam, and in Kansas City begins an overlap with I-70, US-24 and US-40 which it follows into Missouri.
The Chicago–Kansas City Expressway is a highway that runs between Chicago, Illinois, and Kansas City, Missouri. The road is known as Route 110 in Missouri and Illinois Route 110 (IL 110) in Illinois. IL 110 was created through legislation on May 27, 2010, as the designated route for the Illinois portion of the Chicago–Kansas City Expressway.
I-29 / US 71 near Tracy 
US 59 at the Kansas state line
