Mitchell Lazar | |
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Born | 1956 |
Alma mater | |
Known for | discovery of resistin |
Scientific career | |
Institutions |
Mitchell Lazar (born 1956) is an endocrinologist and physician-scientist known for his discovery of the hormone resistin [1] and his contributions to the transcriptional regulation of metabolism.
Lazar is the Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases, and the Director of the Institute for Diabetes, Obesity and Metabolism at the University of Pennsylvania.
Lazar graduated from Syosset High School,[ citation needed ] and three years later received his undergraduate degree in Chemistry from the Massachusetts Institute of Technology, then received a PhD in Neurosciences and an MD from Stanford University. He trained in Internal Medicine at Brigham and Women's Hospital in Boston and in Endocrinology at the Massachusetts General Hospital before joining the University of Pennsylvania faculty in 1989.
Lazar's research focus is on the epigenomic regulation of gene expression and metabolism. He is particularly interested in nuclear receptors, which are master regulators of metabolism. Lazar's findings relate to the basic mechanisms of nuclear receptor action and their role in obesity and diabetes, most notably the discovery of the hormone resistin. [2]
Lazar is a former member of the Board of Scientific Councilors of the National Institutes of Diabetes, Digestive, and Kidney Diseases. He has served as Associate Editor of Diabetes, and is on the editorial boards of Genes & Development, Cell Metabolism, Trends in Endocrinology and Metabolism, Endocrine Reviews, JCI, and Science.
Lazar has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has received two NIH MERIT Awards, the Van Meter Award of the American Thyroid Association, the BMS Freedom to Discover Award, the Richard Weitzman Award and the Edwin B. Astwood Award Lecture from the Endocrine Society, and the Stanley J. Korsmeyer Award of the American Society for Clinical Investigation. He was elected to the National Academy of Medicine in 2006, and to the American Academy of Arts and Sciences in 2008. He is the recipient of the 2014 Transatlantic Medal of the Society for Endocrinology. In 2017 Dr. Lazar was elected to the National Academy of Sciences . [3]
Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Specializations include behavioral endocrinology and comparative endocrinology.
Resistin also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich peptide hormone derived from adipose tissue that in humans is encoded by the RETN gene.
Ronald Mark Evans is an American Biologist, Professor and Head of the Salk’s Gene Expression Laboratory, and the March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute for Biological Studies in La Jolla, California and a Howard Hughes Medical Institute Investigator. Dr. Ronald M. Evans is known for his original discoveries of nuclear hormone receptors (NR), a special class of transcriptional factor, and the elucidation of their universal mechanism of action, a process that governs how lipophilic hormones and drugs regulate virtually every developmental and metabolic pathway in animals and humans. Nowadays, NRs are among the most widely investigated group of pharmaceutical targets in the world, already yielding benefits in drug discovery for cancer, muscular dystrophies, osteoporosis, type II diabetes, obesity, and cardiovascular diseases. His current research focuses on the function of nuclear hormone signaling and their function in metabolism and cancer.
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Shashank R. Joshi is an Indian endocrinologist, diabetologist and medical researcher, considered by many as one of the prominent practitioners of the trade in India. He was honoured by the Government of India, in 2014, by bestowing on him the Padma Shri, the fourth highest civilian award, for his services to the field of medicine. He is a part of the COVID-19 Task Force for the state of Maharashtra, India.
The American Association of Clinical Endocrinology (AACE), formerly known as the American Association of Clinical Endocrinologists, is a professional community of physicians specializing in endocrinology, diabetes, and metabolism. AACE's mission is elevating clinical endocrinology to improve global health. The association is headquartered in Jacksonville, Florida, US.
Matthias H. Tschöp is a German physician and scientist. He is the chief executive officer and scientific director of Helmholtz Zentrum München, German Research Center for Environmental Health. He is also Alexander von Humboldt Professor and Chair of Metabolic Diseases at Technical University of Munich and serves as an adjunct professor at Yale University.
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