Academic career
Moghimi was the senior lecturer of Biopharmacy and Molecular Pharmaceutics at the School of Pharmacy,University of Brighton from 1998 until 2008. From 2008 until 2010,he was honorary professor of nanomedicine at the Multidisciplinary Research Center,Shantou University. [4]
He was also a full affiliate professor at the Methodist Research Institute,Houston Methodist Hospital systems in Texas between 2013 and 2017. [5] In 2015,he was a visiting professor at Universitàdegli Studi di Padova. [6]
From 2008 until 2016, [4] he was professor of nanomedicine in the department of pharmacy and professor of pharmaceutical nanotechnology at the Nanoscience Center, [7] [8] as well as the founder and director of the Centre for Pharmaceutical Nanotechnology and Nanotoxiocology at the University of Copenhagen. [9] [10]
Prior to 2017,Moghimi was professor and chair in pharmaceutics at the Durham University School of Medicine,Pharmacy and Health. Since 2017,he has been professor of Pharmaceutics and Nanomedicine at the School of Pharmacy and Translational and Clinical Research Institute,both part of Newcastle University. He is adjoint professor at the department of pharmaceutical sciences at Skaggs School of Pharmacy,University of Colorado Denver Medical Center. [4]
Research
Moghimi is known for his work in nanoparticle engineering for biomedical applications,nanosafety,and mechanistic understanding of nanoparticle-mediated complement activation. His research focuses on interdisciplinary approaches to nanotherapies. [16] [17] Much of his research is related to the management and treatment of chronic conditions associated with population ageing including cancer, [18] neurological disorders such as Parkinson's disease and Alzheimer's disease,cardiovascular disease,allergies and arthritis. [6] He specializes in the design and surface engineering of nanosystems and nanoparticles for tissue-specific drug delivery and imaging. [7] [19] [20]
His current work includes the development of a concomitant long-term computational network assessment of genomics and epigenomic factors in inter-individual variations to nanomedicine performance and cell re-programming. [4]
Resulting from his PhD research,Moghimi introduced the opsonin-dysopsonin hypothesis,suggesting a regulatory role for certain blood proteins in limiting nanoparticle uptake by macrophages. [21] This hypothesis was later applied to highlight multifaceted mechanisms regulating the pharmacokinetic performance of long-circulating drug carriers. [22] [23]
Moghimi has developed a range of injectable nanosystems,including an early prototype of splenotropic and lymphotropic nanoparticles based on the concept of steric stabilisation and surface engineering with block copolymers. These concepts are applied for splenic and lymphatic targeting with liposomes and polymeric nanospheres. [24] [25]
A research group led by Moghimi developed NanoLigand Carriers, [26] induced self-assemblies of phage-derived display peptides that on intravenous injection rapidly target two receptors on the blood brain-barrier. On crossing the blood–brain barrier,the carriers target neurons and microglia and deliver their therapeutic nucleic acid payloads to cells. These peptides have applications for the treatment of neurodegenerative disorders. [27] [28]
His laboratory was among the first to explain polycation-mediated cell death processes. [29] [30] Moghimi's laboratory has contributed to the molecular understanding of nanomaterial interactions with elements of the innate immune system and translating these to design immune safe nanoparticles. His laboratory demonstrated the first in vivo assembly of long-circulating and splenotropic nanoparticles without prior surface modification or manipulation of macrophage function, [31] as well as the first demonstration of the detection of stealth nanoparticles by primed and activated immune cells. [32]
This research has involved mapping nanoparticle properties that trigger complement activation and,notably,the role of polymer conformation and hydration in switching complement activation pathways. [33] He has resolved some challenging mechanisms modulating complement activation by stealth and polymer-coated nanoparticles. [34] His research also explained the molecular basis of complement activation by polyethylene glycol,a polymer that is used widely for prolonging the blood circulation time of proteins and particulate drug carriers. [35] [36]
His lab was the first to demonstrate tumour growth promotion by stealth nanoparticles through local nanoparticle-mediated complement activation, [37] and developed the first complement-evading hexosomes. [38]
He has challenged the validity of the CARPA (Complement Activation Related Pseudo-Allergy) hypothesis,and proposed a working mechanism explaining idiosyncratic nanomedicine-mediated anaphylaxis seen in patients. [39] [40] Moghimi also introduced the nanomaterial projected "Angstrom-Scale Spacing Arrangement" hypothesis,in modulating complement system responses to nanomedicines and medical implants. [41]
In 2020,Moghimi commented on the sudden closure of the Centers of Cancer Nanotechnology Excellence in the United States,and called for support in curiosity driven research in fundamental nanomedicine even in the absence of immediate obvious benefits to society. [42]
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