Motile sperm domain containing 3

MOSPD3
Identifiers
Aliases	MOSPD3 , CDS3, NET30, Motile sperm domain containing 3
External IDs	OMIM: 609125; MGI: 1916179; HomoloGene: 11406; GeneCards: MOSPD3; OMA:MOSPD3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 100,612,102 bp [1] End 100,615,384 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 G2|5 76.59 cM Start 137,594,907 bp [2] End 137,599,320 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right adrenal cortex left adrenal cortex skin of leg ganglionic eminence sperm right lobe of liver skin of abdomen ectocervix Top expressed in zygote granulocyte yolk sac tail of embryo right kidney lip genital tubercle esophagus neural tube superior cervical ganglion More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 64598 68929 Ensembl ENSG00000106330 ENSMUSG00000037221 UniProt O75425 Q8BGG6 RefSeq (mRNA) NM_001040097 NM_001040098 NM_001040099 NM_023948 NM_001363415 NM_001363416 NM_001254762 NM_030037 RefSeq (protein) NP_001035186 NP_001035187 NP_001035188 NP_076438 NP_001350344 NP_001350345 NP_001241691 NP_084313 Location (UCSC) Chr 7: 100.61 – 100.62 Mb Chr 5: 137.59 – 137.6 Mb PubMed search [3] [4]
Wikidata
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Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene. ^[5]

Function

This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.

References

1. GRCh38: Ensembl release 89: ENSG00000106330 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037221 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Motile sperm domain containing 3".

Further reading

• Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (October 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Research. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC   310788 . PMID   9799793.
• Pall GS, Wallis J, Axton R, Brownstein DG, Gautier P, Buerger K, Mulford C, Mullins JJ, Forrester LM (December 2004). "A novel transmembrane MSP-containing protein that plays a role in right ventricle development". Genomics. 84 (6): 1051–9. doi:10.1016/j.ygeno.2004.08.017. PMID   15533722.
• Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AW, Akkermans JJ, Wijdeven RH, Janssen GM, van Veelen PA, Neefjes J (December 2020). "Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs". Cell Reports. 33 (10) 108475. doi: 10.1016/j.celrep.2020.108475 . hdl: 1887/3184381 . PMID   33296653. S2CID   228090430.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.