| MOSPD3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MOSPD3 , CDS3, NET30, Motile sperm domain containing 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609125 MGI: 1916179 HomoloGene: 11406 GeneCards: MOSPD3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene. [5]
This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.
Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme that in humans is encoded by the MBTPS1 gene. S1P cleaves the endoplasmic reticulum loop of sterol regulatory element-binding protein (SREBP) transcription factors.
Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.
Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.
Hyaluronidase PH-20 is an enzyme that in humans is encoded by the SPAM1 gene.
Protein misato homolog 1 is a protein that in humans is encoded by the MSTO1 gene.
Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.
Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.
Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.
Cysteine-rich secretory protein 1 is a cysteine-rich secretory protein that in humans is encoded by the CRISP1 gene.
MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.
Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.
Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.
Beta-tectorin is a protein that in humans is encoded by the TECTB gene.
Disintegrin and metalloproteinase domain-containing protein 7 is a protein that in humans is encoded by the ADAM7 gene. ADAM7 is an 85-kDa enzyme that is a member of the transmembrane ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM7 is important for the maturation of sperm cells in mammals. ADAM7 is also denoted as: ADAM_7, ADAM-7, EAPI, GP-83, and GP83.
Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene.
Motile sperm domain containing 1 is a protein that in humans is encoded by the MOSPD1 gene.
Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene. It is an endoplasmic reticulum–resident protein involved in membrane contact site formation. Its domain homologous to Major Sperm Protein is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.
Methylsterol monooxygenase 1 is a protein that in humans is encoded by the MSMO1 gene.
Coiled-coil domain-containing protein 181 (CCDC181) is a protein that in human is encoded by C1orf114, which is located at the Chromosome 1 at 1q24.2. The accession is Q5T1D7. Researches have recently revealed that CCDC 181 is a microtubule-binding protein that interacts with murine Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia. The disruption of Hook1 may lead to inappropriate function of spermatogenesis. The dysfunction may be related to the abnormal head shape of sperm or distinctive structural changes in flagella in sperm, which can result in male infertility. An increased rate of my gene has found in the haploid phase of male cell during meiosis, thus it is believed to relate to sperm cell and aid in spermatogenesis.
Trafficking protein particle complex 6A is a protein that in humans is encoded by the TRAPPC6A gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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