Myosin light chain 5

MYL5
Identifiers
Aliases	MYL5 , myosin light chain 5, MYLC2
External IDs	OMIM: 160782 HomoloGene: 48110 GeneCards: MYL5
Gene location (Human)
Chr.	Chromosome 4 (human)
End	682,033 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; sural nerve; ; right lobe of liver; ; body of stomach; ; left lobe of thyroid gland; ; gastric mucosa; ; cingulate gyrus; ; right uterine tube; ; right lobe of thyroid gland; ; minor salivary gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding ; structural constituent of muscle ; metal ion binding ;
Cellular component	cytosol ; muscle myosin complex ; myosin complex ;
Biological process	regulation of muscle contraction ; muscle contraction ;
	Sources:Amigo / QuickGO
Orthologs
	4636
	n/a
	ENSG00000215375
	n/a
	Q02045
	n/a
	NM_002477 ; NM_001363650
	n/a
	NP_002468 ; NP_001350579
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Myosin light chain 5 is a protein that, in humans, is encoded by the MYL5 gene. ^[3]

Function

This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia.

Related Research Articles

MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform expressed primarily in the heart, but also in skeletal muscles. This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament in cardiac muscle and plays a major role in cardiac muscle contraction.

Myosin regulatory light polypeptide 9 is a protein that in humans is encoded by the MYL9 gene.

Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction.

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.

Myosin-3 is a protein that in humans is encoded by the MYH3 gene.

Myosin-8 is a protein that in humans is encoded by the MYH8 gene.

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

Myosin regulatory light chain 12A is a protein that in humans is encoded by the MYL12A gene.

Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans is encoded by the MYL7 gene. ALC-2 expression is restricted to cardiac muscle atria in healthy individuals, where it functions to modulate cardiac development and contractility. In human diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and others, ALC-2 expression is altered.

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene. Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.

Clathrin, light chain B is a protein in humans that is encoded by the CLTB gene.

Canopy FGF signaling regulator 2 is a protein that in humans is encoded by the CNPY2 gene.

Myosin light chain, phosphorylatable, fast skeletal muscle is a protein that in humans is encoded by the MYLPF gene. It is located on chromosome 16 in humans. Myosin light chain, phosphorylatable

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000215375 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Myosin light chain 5" . Retrieved 2017-01-24.

Myosin light chain 5

Contents

Function

Related Research Articles

References

Further reading