NAP1L1

NAP1L1
Identifiers
Aliases	NAP1L1 , NAP1, NAP1L, NRP, nucleosome assembly protein 1 like 1
External IDs	OMIM: 164060 MGI: 1855693 HomoloGene: 129218 GeneCards: NAP1L1
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q21.2 Start 76,036,585 bp [1] End 76,084,735 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence secondary oocyte ovary lower lobe of lung right lung monocyte lymph node endometrium germinal epithelium n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component melanosome membrane nucleus cytoplasm Biological process DNA replication nucleosome assembly positive regulation of cell population proliferation nervous system development positive regulation of neurogenesis positive regulation of neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4673 53605 Ensembl ENSG00000187109 n/a UniProt P55209 P28656 RefSeq (mRNA) NM_001307924 NM_004537 NM_139207 NM_001330231 NM_001330232 NM_001146707 NM_015781 NM_001358932 RefSeq (protein) NP_001294853 NP_001317160 NP_001317161 NP_004528 NP_631946 NP_056596 NP_001345861 Location (UCSC) Chr 12: 76.04 – 76.08 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Nucleosome assembly protein 1-like 1 is a protein that in humans is encoded by the NAP1L1 gene. ^{[4] [5]}

This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing of this gene results in several transcript variants; however, not all have been fully described. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000187109 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Simon HU, Mills GB, Kozlowski M, Hogg D, Branch D, Ishimi Y, Siminovitch KA (Mar 1994). "Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation". Biochem J. 297 (2): 389–97. doi:10.1042/bj2970389. PMC   1137842 . PMID   8297347.
5. "Entrez Gene: NAP1L1 nucleosome assembly protein 1-like 1".

Further reading

• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Asahara H, Tartare-Deckert S, Nakagawa T, et al. (2002). "Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro". Mol. Cell. Biol. 22 (9): 2974–83. doi:10.1128/MCB.22.9.2974-2983.2002. PMC   133748 . PMID   11940655.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Rehtanz M, Schmidt HM, Warthorst U, Steger G (2004). "Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription". Mol. Cell. Biol. 24 (5): 2153–68. doi:10.1128/MCB.24.5.2153-2168.2004. PMC   350572 . PMID   14966293.
• Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi: 10.1073/pnas.0403413101 . PMC   515085 . PMID   15308774.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Okuwaki M, Kato K, Shimahara H, et al. (2005). "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I." Mol. Cell. Biol. 25 (23): 10639–51. doi:10.1128/MCB.25.23.10639-10651.2005. PMC   1291234 . PMID   16287874.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID   17081065.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Eckey M, Hong W, Papaioannou M, Baniahmad A (2007). "The nucleosome assembly activity of NAP1 is enhanced by Alien". Mol. Cell. Biol. 27 (10): 3557–68. doi:10.1128/MCB.01106-06. PMC   1899999 . PMID   17339334.