NDN (gene)

NDN
Identifiers
Aliases	NDN , HsT16328, PWCR, necdin, MAGE family member
External IDs	OMIM: 602117 MGI: 97290 HomoloGene: 20559 GeneCards: NDN
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q11.2 Start 23,685,400 bp [1] End 23,687,305 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 34.36 cM|7 C Start 61,996,317 bp [2] End 62,000,010 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell internal globus pallidus canal of the cervix nucleus accumbens hypothalamus urethra parietal pleura ganglionic eminence pons superior vestibular nucleus Top expressed in dorsomedial hypothalamic nucleus median eminence arcuate nucleus ventromedial nucleus paraventricular nucleus of hypothalamus superior cervical ganglion suprachiasmatic nucleus lateral hypothalamus supraoptic nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding gamma-tubulin binding Cellular component cytoplasm perikaryon centrosome cell projection nucleus nucleoplasm cytosol Biological process respiratory system process genetic imprinting neurotrophin TRK receptor signaling pathway regulation of transcription, DNA-templated axonogenesis neuron development neuron migration multicellular organismal homeostasis transcription by RNA polymerase II post-embryonic development transcription, DNA-templated nervous system development respiratory gaseous exchange by respiratory system central nervous system development axon extension sensory perception of pain regulation of growth axonal fasciculation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation glial cell migration cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4692 17984 Ensembl ENSG00000182636 ENSG00000288364 ENSMUSG00000033585 UniProt Q99608 P25233 RefSeq (mRNA) NM_002487 NM_010882 RefSeq (protein) NP_002478 NP_035012 Location (UCSC) Chr 15: 23.69 – 23.69 Mb Chr 7: 62 – 62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Necdin is a protein that in humans is encoded by the NDN gene. ^{[5] [6]}

Function

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. ^[6]

Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation. ^[7]

Interactions

NDN (gene) has been shown to interact with:

• E2F1, ^{[8] [9]}
• HNRNPU, ^[10]
• IL1A, ^[11]
• Low affinity nerve growth factor receptor, ^{[9] [12] [13]}
• NUCB2, ^[14] and
• P53 ^[15]

References

1. ENSG00000288364 GRCh38: Ensembl release 89: ENSG00000182636, ENSG00000288364 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033585 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. MacDonald HR, Wevrick R (January 1998). "The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse". Hum Mol Genet. 6 (11): 1873–8. doi: 10.1093/hmg/6.11.1873 . PMID   9302265.
6. "Entrez Gene: NDN necdin homolog (mouse)".
7. Uniprot
8. Taniura H, Taniguchi N, Hara M, Yoshikawa K (January 1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. doi: 10.1074/jbc.273.2.720 . PMID   9422723.
9. Kuwako K, Taniura H, Yoshikawa K (January 2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi: 10.1074/jbc.M308454200 . PMID   14593116.
10. Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID   11813259. S2CID   5988824.
11. Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (August 2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. Bibcode:2003PNAS..10010008H. doi: 10.1073/pnas.1737765100 . PMC   187743 . PMID   12913118.
12. Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (April 2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. doi:10.1523/JNEUROSCI.23-08-03209.2003. PMC   6742322 . PMID   12716928.
13. Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M (December 2002). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi: 10.1074/jbc.C200533200 . PMID   12414813.
14. Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi: 10.1074/jbc.M005103200 . PMID   10915798.
15. Taniura H, Matsumoto K, Yoshikawa K (June 1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi: 10.1074/jbc.274.23.16242 . PMID   10347180.

Further reading

• Aizawa T, Maruyama K, Kondo H, Yoshikawa K (1992). "Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain". Brain Res. Dev. Brain Res. 68 (2): 265–74. doi:10.1016/0165-3806(92)90069-9. PMID   1394972.
• Jay P, Rougeulle C, Massacrier A, Moncla A, Mattei MG, Malzac P, Roëckel N, Taviaux S, Lefranc JL, Cau P, Berta P, Lalande M, Muscatelli F (1997). "The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region". Nat. Genet. 17 (3): 357–61. doi:10.1038/ng1197-357. PMID   9354807. S2CID   3142428.
• Taniura H, Taniguchi N, Hara M, Yoshikawa K (1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. doi: 10.1074/jbc.273.2.720 . PMID   9422723.
• Nakada Y, Taniura H, Uetsuki T, Inazawa J, Yoshikawa K (1998). "The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region". Gene. 213 (1–2): 65–72. doi:10.1016/S0378-1119(98)00206-6. PMID   9630521.
• Taniura H, Matsumoto K, Yoshikawa K (1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi: 10.1074/jbc.274.23.16242 . PMID   10347180.
• Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi: 10.1074/jbc.M005103200 . PMID   10915798.
• Niinobe M, Koyama K, Yoshikawa K (2000). "Cellular and subcellular localization of necdin in fetal and adult mouse brain". Dev. Neurosci. 22 (4): 310–9. doi:10.1159/000017455. PMID   10965153. S2CID   30494989.
• Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID   11813259. S2CID   5988824.
• Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi: 10.1074/jbc.M109728200 . PMID   11959851.
• Kobayashi M, Taniura H, Yoshikawa K (2003). "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells". J. Biol. Chem. 277 (44): 42128–35. doi: 10.1074/jbc.M205024200 . PMID   12198120.
• Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M (2003). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi: 10.1074/jbc.C200533200 . PMID   12414813.
• Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. doi: 10.1523/JNEUROSCI.23-08-03209.2003 . PMC   6742322 . PMID   12716928.
• Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. Bibcode:2003PNAS..10010008H. doi: 10.1073/pnas.1737765100 . PMC   187743 . PMID   12913118.
• Kuwako K, Taniura H, Yoshikawa K (2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi: 10.1074/jbc.M308454200 . PMID   14593116.
• Lau JC, Hanel ML, Wevrick R (2004). "Tissue-specific and imprinted epigenetic modifications of the human NDN gene". Nucleic Acids Res. 32 (11): 3376–82. doi:10.1093/nar/gkh671. PMC   443546 . PMID   15247330.
• Moon HE, Ahn MY, Park JA, Min KJ, Kwon YW, Kim KW (2005). "Negative regulation of hypoxia inducible factor-1alpha by necdin". FEBS Lett. 579 (17): 3797–801. doi:10.1016/j.febslet.2005.05.072. PMID   15978586. S2CID   85286669.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.