NEIL3

NEIL3
Identifiers
Aliases	NEIL3 , FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, nei like DNA glycosylase 3
External IDs	OMIM: 608934; MGI: 2384588; HomoloGene: 10094; GeneCards: NEIL3; OMA:NEIL3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q34.3 Start 177,309,874 bp [1] End 177,362,936 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B1.3 Start 54,039,902 bp [2] End 54,092,100 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone testicle secondary oocyte ganglionic eminence stromal cell of endometrium bone marrow pancreatic ductal cell bone marrow cells rectum Top expressed in zygote secondary oocyte primary oocyte thymus genital tubercle spermatid tail of embryo tibiofemoral joint fetal liver hematopoietic progenitor cell granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding zinc ion binding hydrolase activity, hydrolyzing N-glycosyl compounds metal ion binding hydrolase activity, acting on glycosyl bonds damaged DNA binding catalytic activity lyase activity nucleic acid binding hydrolase activity DNA N-glycosylase activity bubble DNA binding DNA-(apurinic or apyrimidinic site) endonuclease activity single-stranded DNA binding double-stranded DNA binding class I DNA-(apurinic or apyrimidinic site) endonuclease activity Cellular component nucleoplasm nucleus Biological process nucleotide-excision repair cellular response to DNA damage stimulus metabolism DNA repair base-excision repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55247 234258 Ensembl ENSG00000109674 ENSMUSG00000039396 UniProt Q8TAT5 Q8K203 RefSeq (mRNA) NM_018248 NM_146208 RefSeq (protein) NP_060718 NP_666320 Location (UCSC) Chr 4: 177.31 – 177.36 Mb Chr 8: 54.04 – 54.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene. ^[5]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction. ^[6]

See also

• OGG1
• NTHL1
• NEIL1
• NEIL2

References

1. GRCh38: Ensembl release 89: ENSG00000109674 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039396 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)".
6. Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID   12509226.