NEO1

NEO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2
Identifiers
Aliases	NEO1 , IGDCC2, NGN, NTN1R2, neogenin 1
External IDs	OMIM: 601907; MGI: 1097159; HomoloGene: 1870; GeneCards: NEO1; OMA:NEO1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.1 Start 73,051,710 bp [1] End 73,305,205 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 58,781,970 bp [2] End 58,943,724 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone internal globus pallidus inferior ganglion of vagus nerve rectum epithelium of colon subthalamic nucleus corpus callosum ventral tegmental area superior vestibular nucleus pylorus Top expressed in external carotid artery internal carotid artery epithelium of lens renal corpuscle medullary collecting duct substantia nigra ciliary body ascending aorta Rostral migratory stream aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-receptor binding protein binding signaling receptor activity Cellular component integral component of membrane plasma membrane protein complex plasma membrane Golgi apparatus integral component of plasma membrane membrane nucleoplasm Biological process positive regulation of BMP signaling pathway iron ion homeostasis cell adhesion nervous system development axon guidance signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4756 18007 Ensembl ENSG00000067141 ENSMUSG00000032340 UniProt Q92859 P97798 RefSeq (mRNA) NM_001172623 NM_001172624 NM_002499 NM_001042752 NM_008684 RefSeq (protein) NP_001166094 NP_001166095 NP_002490 n/a Location (UCSC) Chr 15: 73.05 – 73.31 Mb Chr 9: 58.78 – 58.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neogenin is a protein that in humans is encoded by the NEO1 gene. ^{[5] [6]}

Interactions

NEO1 has been shown to interact with PTK2. ^[7] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000067141 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032340 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi: 10.1038/sj.onc.1200935 . PMID   9121761.
6. "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
7. Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi: 10.1038/nn1330 . PMID   15494733. S2CID   2901216.
8. Do Carmo Costa, Alinne; Copola, Aline Gonçalves Lio; Carvalho e Souza, Clara; Nogueira, Júlia Meireles; Silva, Gerluza Aparecida Borges; Jorge, Erika Cristina (2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway" . In Vitro Cellular & Developmental Biology - Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID   33748906. S2CID   232311370.

Further reading

• Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC   2120299 . PMID   7806578.
• Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell. 87 (2): 175–85. doi: 10.1016/S0092-8674(00)81336-7 . PMID   8861902.
• Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics. 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID   9169140.
• Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors". J. Neurosci. 19 (12): 4938–47. doi: 10.1523/JNEUROSCI.19-12-04938.1999 . PMC   6782680 . PMID   10366627.
• Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell. 4 (3): 371–82. doi: 10.1016/S1534-5807(03)00054-6 . PMID   12636918.
• Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi: 10.1038/sj.onc.1206437 . PMID   12833147.
• Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A (2004). "RGM and its receptor neogenin regulate neuronal survival". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID   15258591. S2CID   15433313.
• Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi: 10.1038/nn1330 . PMID   15494733. S2CID   2901216.
• Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer". BMC Cancer. 5: 154. doi: 10.1186/1471-2407-5-154 . PMC   1322231 . PMID   16324219.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.