NEO1

NEO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2
Identifiers
Aliases	NEO1 , IGDCC2, NGN, NTN1R2, neogenin 1
External IDs	OMIM: 601907 MGI: 1097159 HomoloGene: 1870 GeneCards: NEO1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	73,305,205 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	58,943,724 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; inferior ganglion of vagus nerve; ; rectum; ; subthalamic nucleus; ; corpus callosum; ; ventral tegmental area; ; superior vestibular nucleus; ; pylorus; ; external globus pallidus; ; nipple;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; renal corpuscle; ; medullary collecting duct; ; substantia nigra; ; ciliary body; ; ascending aorta; ; aortic valve; ; iris; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding ; protein binding ; signaling receptor activity ;
Cellular component	integral component of membrane ; plasma membrane protein complex ; plasma membrane ; Golgi apparatus ; integral component of plasma membrane ; membrane ; nucleoplasm ;
Biological process	positive regulation of BMP signaling pathway ; iron ion homeostasis ; cell adhesion ; nervous system development ; axon guidance ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	4756
	18007
	ENSG00000067141
	ENSMUSG00000032340
	Q92859
	P97798
	NM_001172623 ; NM_001172624 ; NM_002499
	NM_001042752 ; NM_008684
	NP_001166094 ; NP_001166095 ; NP_002490
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[5]^[6]

Interactions

NEO1 has been shown to interact with PTK2.^[7] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. ^[8]

Related Research Articles

Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word "netr", which means "one who guides". Netrins are genetically conserved across nematode worms, fruit flies, frogs, mice, and humans. Structurally, netrin resembles the extracellular matrix protein laminin.

Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer and its previous name was Deleted in colorectal carcinoma. Netrin receptor DCC is a single transmembrane receptor.

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

EPH receptor A2 is a protein that in humans is encoded by the EPHA2 gene.

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.

Roundabout homolog 1 is a protein that in humans is encoded by the ROBO1 gene.

Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1 gene.

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.

Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.

Netrin-G1 is a protein that in humans is encoded by the NTNG1 gene.

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.

Repulsive guidance molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A and BMPR1B, as well as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling pathway. In humans this protein is encoded by the RGMA gene.

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.

Repulsive guidance molecule B (RGMb), also known as DRAGON, is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. In humans this protein is encoded by the RGMB gene.

Slit-Robo is the name of a cell signaling protein complex with many diverse functions including axon guidance and angiogenesis.

The growth cone is a highly dynamic structure of the developing neuron, changing directionality in response to different secreted and contact-dependent guidance cues; it navigates through the developing nervous system in search of its target. The migration of the growth cone is mediated through the interaction of numerous trophic and tropic factors; netrins, slits, ephrins and semaphorins are four well-studied tropic cues (Fig.1). The growth cone is capable of modifying its sensitivity to these guidance molecules as it migrates to its target; this sensitivity regulation is an important theme seen throughout development.

UNC-5 is a receptor for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000067141 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032340 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi: 10.1038/sj.onc.1200935 . PMID 9121761.
↑ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
↑ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
↑ Do Carmo Costa, Alinne; Copola, Aline Gonçalves Lio; Carvalho e Souza, Clara; Nogueira, Júlia Meireles; Silva, Gerluza Aparecida Borges; Jorge, Erika Cristina (2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology - Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.

Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC 2120299 . PMID 7806578.
Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell. 87 (2): 175–85. doi: 10.1016/S0092-8674(00)81336-7 . PMID 8861902.
Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics. 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID 9169140.
Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors". J. Neurosci. 19 (12): 4938–47. doi: 10.1523/JNEUROSCI.19-12-04938.1999 . PMC 6782680 . PMID 10366627.
Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell. 4 (3): 371–82. doi: 10.1016/S1534-5807(03)00054-6 . PMID 12636918.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi: 10.1038/sj.onc.1206437 . PMID 12833147.
Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A (2004). "RGM and its receptor neogenin regulate neuronal survival". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID 15258591. S2CID 15433313.
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer". BMC Cancer. 5: 154. doi: 10.1186/1471-2407-5-154 . PMC 1322231 . PMID 16324219.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943 . PMID 16335952.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000067141 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032340 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9121761-5] Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi: 10.1038/sj.onc.1200935 . PMID 9121761.

[entrez-6] "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".

[pmid15494733-7] Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.

[8] Do Carmo Costa, Alinne; Copola, Aline Gonçalves Lio; Carvalho e Souza, Clara; Nogueira, Júlia Meireles; Silva, Gerluza Aparecida Borges; Jorge, Erika Cristina (2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology - Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.

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NEO1

Contents

Interactions

Related Research Articles

References

Further reading