NFAM1

NFAM1
Identifiers
Aliases	NFAM1 , CNAIP, bK126B4.4, NFAT activating protein with ITAM motif 1
External IDs	OMIM: 608740 MGI: 1921289 HomoloGene: 12528 GeneCards: NFAM1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2 Start 42,380,407 bp [1] End 42,432,403 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 82,877,174 bp [2] End 82,917,507 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood pancreatic ductal cell bone marrow cells spleen appendix cancellous bone cerebellar vermis synovial membrane sperm Top expressed in bone marrow blood spleen habenula lip thymus right lung lobe calvaria esophagus superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane azurophil granule membrane Biological process positive regulation of B cell receptor signaling pathway cell surface receptor signaling pathway positive regulation of DNA-binding transcription factor activity intracellular signal transduction inflammatory response regulation of B cell differentiation signal transduction positive regulation of cytokine production neutrophil degranulation B cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150372 74039 Ensembl ENSG00000235568 ENSMUSG00000058099 UniProt Q8NET5 Q8R4V1 RefSeq (mRNA) NM_145912 NM_001318323 NM_001371362 NM_001271411 NM_001271412 NM_001271413 NM_001271414 NM_028728 RefSeq (protein) NP_001305252 NP_666017 NP_001358291 NP_001258340 NP_001258341 NP_001258342 NP_001258343 NP_083004 Location (UCSC) Chr 22: 42.38 – 42.43 Mb Chr 15: 82.88 – 82.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene. ^[5]

Function

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000235568 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058099 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NFAT activating protein with ITAM motif 1" . Retrieved 2018-03-13.

Further reading

• Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z (May 2003). "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. doi: 10.1074/jbc.M211060200 . PMID   12615919.
• Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF (March 2007). "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation" (PDF). Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. doi:10.1152/ajpcell.00590.2005. PMID   17079331.
• Manley K, O'Hara BA, Atwood WJ (March 2008). "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology. 372 (1): 48–55. doi:10.1016/j.virol.2007.10.029. PMC   2289909 . PMID   18031784.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.