Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.
Chemokine ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of Sonic hedgehog, becoming target of transforming insults. Remarkably, the treatment with CXCL3 completely prevents the growth of medulloblastoma lesions in a Shh-type mouse model of medulloblastoma. Thus, CXCL3 is a target for medulloblastoma therapy. Cxcl3 is directly regulated transcriptionally by BTG2
Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.
Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.
CD244 is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4
Granzyme A is a protein that in humans is encoded by the GZMA gene, and is one of the five granzymes encoded in the human genome.
Granzyme H is a protein that in humans is encoded by the GZMH gene.
Granzyme K is a protein that in humans is encoded by the GZMK gene.
Granzyme M is a protein that in humans is encoded by the GZMM gene.
Zymogen granule protein 16, also known as ZG16, is a human gene.
Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.
Gap junction delta-4 protein (GJD4), also known as connexin-40.1 (Cx40.1), is a protein that in humans is encoded by the GJD4 gene.
Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.
MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.
Monocarboxylate transporter 6 (MCT6) is a protein in humans that is encoded by the SLC16A5 gene.
Ubiquitin-like 7 is a protein in humans that is encoded by the UBL7 gene.
Protein Wnt-8a is a protein that in humans is encoded by the WNT8A gene. Wnt8a may be involved in development of early embryos as well as germ cell tumors.
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.
Ring finger protein 19B is a protein that in humans is encoded by the RNF19B gene.
Serine protease 57 is a protein that in humans is encoded by the PRSS57 gene.
