NKTR

NKTR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HE9
Identifiers
Aliases	NKTR , p104, natural killer cell triggering receptor
External IDs	OMIM: 161565; MGI: 97346; HomoloGene: 122148; GeneCards: NKTR; OMA:NKTR - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p22.1 Start 42,600,655 bp [1] End 42,648,735 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 F4|9 72.57 cM Start 121,719,169 bp [2] End 121,756,843 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus cardia caput epididymis tail of epididymis optic nerve Achilles tendon corpus epididymis superior surface of tongue visceral pleura corpus callosum Top expressed in ascending aorta neural layer of retina aortic valve tail of embryo genital tubercle cerebellar cortex dorsomedial hypothalamic nucleus Rostral migratory stream habenula superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function isomerase activity peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding unfolded protein binding Cellular component membrane nucleoplasm mitochondrion cytosol plasma membrane nucleus Biological process protein folding protein peptidyl-prolyl isomerization protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4820 18087 Ensembl ENSG00000114857 ENSMUSG00000032525 UniProt P30414 P30415 RefSeq (mRNA) NM_001012651 NM_005385 NM_001349124 NM_001349125 NM_001349126 NM_010918 RefSeq (protein) NP_005376 NP_001336053 NP_001336054 NP_001336055 NP_035048 Location (UCSC) Chr 3: 42.6 – 42.65 Mb Chr 9: 121.72 – 121.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene. ^{[5] [6] [7]}

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114857 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032525 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID   8314596.
6. Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. doi: 10.4049/jimmunol.152.6.2669 . PMID   8144875. S2CID   20265645.
7. "Entrez Gene: NKTR natural killer-tumor recognition sequence".

Further reading

• Frey JL, Bino T, Kantor RR, et al. (1992). "Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes". J. Exp. Med. 174 (6): 1527–1536. doi:10.1084/jem.174.6.1527. PMC   2119033 . PMID   1720812.
• Rinfret A, Anderson SK (1993). "IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism". Mol. Immunol. 30 (14): 1307–1313. doi:10.1016/0161-5890(93)90047-F. PMID   8413330.
• Anderson SK, Gallinger S, Roder J, et al. (1993). "A cyclophilin-related protein involved in the function of natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 542–546. Bibcode:1993PNAS...90..542A. doi: 10.1073/pnas.90.2.542 . PMC   45699 . PMID   8421688.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–1187. doi:10.1128/MCB.24.3.1174-1187.2004. PMC   321435 . PMID   14729963.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Davis TL, Walker JR, Campagna-Slater V, et al. (2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. 8 (7) e1000439. doi: 10.1371/journal.pbio.1000439 . PMC   2911226 . PMID   20676357.